ID   DTPD_KLEP3              Reviewed;         492 AA.
AC   B5XZE5;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Dipeptide permease D {ECO:0000255|HAMAP-Rule:MF_01880};
GN   Name=dtpD {ECO:0000255|HAMAP-Rule:MF_01880}; OrderedLocusNames=KPK_3851;
OS   Klebsiella pneumoniae (strain 342).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=507522;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=342;
RX   PubMed=18654632; DOI=10.1371/journal.pgen.1000141;
RA   Fouts D.E., Tyler H.L., DeBoy R.T., Daugherty S., Ren Q., Badger J.H.,
RA   Durkin A.S., Huot H., Shrivastava S., Kothari S., Dodson R.J., Mohamoud Y.,
RA   Khouri H., Roesch L.F.W., Krogfelt K.A., Struve C., Triplett E.W.,
RA   Methe B.A.;
RT   "Complete genome sequence of the N2-fixing broad host range endophyte
RT   Klebsiella pneumoniae 342 and virulence predictions verified in mice.";
RL   PLoS Genet. 4:E1000141-E1000141(2008).
CC   -!- FUNCTION: Probable proton-dependent permease that transports
CC       dipeptides. {ECO:0000255|HAMAP-Rule:MF_01880}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01880}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01880}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Proton-
CC       dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. DtpD
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01880}.
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DR   EMBL; CP000964; ACI10327.1; -; Genomic_DNA.
DR   AlphaFoldDB; B5XZE5; -.
DR   SMR; B5XZE5; -.
DR   EnsemblBacteria; ACI10327; ACI10327; KPK_3851.
DR   KEGG; kpe:KPK_3851; -.
DR   HOGENOM; CLU_004790_0_0_6; -.
DR   OMA; GMMMGLW; -.
DR   OrthoDB; 470322at2; -.
DR   Proteomes; UP000001734; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0071916; F:dipeptide transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015333; F:peptide:proton symporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd17346; MFS_DtpA_like; 1.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   HAMAP; MF_01880; PTR2_DtpD_subfam; 1.
DR   InterPro; IPR023777; AA/pep_transptr_DtpD.
DR   InterPro; IPR005279; Dipep/tripep_permease.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR000109; POT_fam.
DR   InterPro; IPR018456; PTR2_symporter_CS.
DR   PANTHER; PTHR11654; PTHR11654; 1.
DR   Pfam; PF00854; PTR2; 1.
DR   SUPFAM; SSF103473; SSF103473; 2.
DR   TIGRFAMs; TIGR00924; yjdL_sub1_fam; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS01022; PTR2_1; 1.
DR   PROSITE; PS01023; PTR2_2; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Peptide transport;
KW   Protein transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..492
FT                   /note="Dipeptide permease D"
FT                   /id="PRO_0000395296"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        212..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        236..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        269..289
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        312..332
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        344..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        379..399
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        413..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        458..478
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
SQ   SEQUENCE   492 AA;  53855 MW;  6A2A3D8910AB2992 CRC64;
     MKTTSSQPRA IYYVVALQIW EYFSFYGMRA LLILYLTNQL KYDDNHAYAL FSAYCSLVYV
     TPILGGYLAD KLLGNRMAVM LGALLMAIGH LVLGASETAP VFLYLSLAII VCGYGLFKSN
     VSCLLGELYE PADPRRDGGF SLMYAAGNIG SIIAPIACGY VQEEYSWAMG FALAAIGMVA
     GLVIFLCGNR HFQHTAGVNR QALCARRFLL PNWGWLLVLL VTAPLLIAVL FWQEWSVYAL
     IVATVIGLAV LARIYLRAET DKQRKDLRLI VVLTAFSLLF WAFAQQGGSS ISLYIDRFVN
     RHIMSYEVPT AMFQSVNAFA VMLCGMVLAW LVKESVGGNR TVRIWGKFAL GLGLMSAGFC
     ILTLSARWSA AYGQSSMPLM VLGLAVMGFA ELFIDPVAMS QITRIEIPGV TGVLTGIYML
     LSGAIANYLA GVIADQTSQA SFDAAGAVNY SIDAYIKVFS QITWGALACV GVVLVIWLYH
     SLKVRTRRLA VE