ID   DTPD_KLEP7              Reviewed;         492 AA.
AC   A6T6E2;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Dipeptide permease D {ECO:0000255|HAMAP-Rule:MF_01880};
GN   Name=dtpD {ECO:0000255|HAMAP-Rule:MF_01880};
GN   OrderedLocusNames=KPN78578_07020; ORFNames=KPN_00720;
OS   Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=272620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700721 / MGH 78578;
RG   The Klebsiella pneumonia Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P.,
RA   Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable proton-dependent permease that transports
CC       dipeptides. {ECO:0000255|HAMAP-Rule:MF_01880}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01880}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01880}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Proton-
CC       dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. DtpD
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01880}.
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DR   EMBL; CP000647; ABR76163.1; -; Genomic_DNA.
DR   RefSeq; WP_004199663.1; NC_009648.1.
DR   AlphaFoldDB; A6T6E2; -.
DR   SMR; A6T6E2; -.
DR   STRING; 272620.KPN_00720; -.
DR   EnsemblBacteria; ABR76163; ABR76163; KPN_00720.
DR   KEGG; kpn:KPN_00720; -.
DR   HOGENOM; CLU_004790_0_0_6; -.
DR   OMA; GMMMGLW; -.
DR   Proteomes; UP000000265; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0071916; F:dipeptide transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015333; F:peptide:proton symporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd17346; MFS_DtpA_like; 1.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   HAMAP; MF_01880; PTR2_DtpD_subfam; 1.
DR   InterPro; IPR023777; AA/pep_transptr_DtpD.
DR   InterPro; IPR005279; Dipep/tripep_permease.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR000109; POT_fam.
DR   InterPro; IPR018456; PTR2_symporter_CS.
DR   PANTHER; PTHR11654; PTHR11654; 1.
DR   Pfam; PF00854; PTR2; 1.
DR   SUPFAM; SSF103473; SSF103473; 2.
DR   TIGRFAMs; TIGR00924; yjdL_sub1_fam; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS01022; PTR2_1; 1.
DR   PROSITE; PS01023; PTR2_2; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Peptide transport;
KW   Protein transport; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..492
FT                   /note="Dipeptide permease D"
FT                   /id="PRO_0000395297"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        212..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        236..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        269..289
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        312..332
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        344..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        379..399
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        413..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        458..478
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
SQ   SEQUENCE   492 AA;  53885 MW;  0E777A0F13AF32D7 CRC64;
     MQTTSSQPRA IYYVVALQIW EYFSFYGMRA LLILYLTNQL KYDDNHAYAL FSAYCSLVYV
     TPILGGYLAD KLLGNRMAVM LGALLMAIGH LVLGASETAP LFLYLSLAII VCGYGLFKSN
     VSCLLGELYE PADPRRDGGF SLMYAAGNIG SIIAPIACGY VQEEYSWAMG FALAAIGMVA
     GLVIFLCGNR HFQHTAGVNR QALCARRFLL PNWGWLLVLL VTAPLLIAVL FWQEWSVYAL
     IVATAIGLAV LARIYLRAET DKQRKDLRLI VVLTAFSLLF WAFAQQGGSS ISLYIDRFVN
     RHIMSYEVPT AMFQSINAFA VMLCGMVLAW LVKESVNGNR TVRIWGKFAL GLGLMSAGFC
     ILTLSARWSA AYGQSSMPLM VLGLAVMGFA ELFIDPVAMS QITRIEIPGV TGVLTGIYML
     LSGAIANYLA GVIADQTSQA SFDAAGAVNY SIDAYITVFS QITWGALACV GVVLVIWLYH
     SLKVRTRRLA VE