DTPD_SALT1
ID DTPD_SALT1 Reviewed; 493 AA.
AC D0ZQC5;
DT 13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT 13-JUL-2010, sequence version 2.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=Dipeptide permease D {ECO:0000255|HAMAP-Rule:MF_01880};
GN Name=dtpD {ECO:0000255|HAMAP-Rule:MF_01880}; OrderedLocusNames=STM14_0829;
OS Salmonella typhimurium (strain 14028s / SGSC 2262).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=588858;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=14028s / SGSC 2262;
RX PubMed=19897643; DOI=10.1128/jb.01233-09;
RA Jarvik T., Smillie C., Groisman E.A., Ochman H.;
RT "Short-term signatures of evolutionary change in the Salmonella enterica
RT serovar typhimurium 14028 genome.";
RL J. Bacteriol. 192:560-567(2010).
CC -!- FUNCTION: Probable proton-dependent permease that transports
CC dipeptides. {ECO:0000255|HAMAP-Rule:MF_01880}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01880}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01880}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Proton-
CC dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. DtpD
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_01880}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ACY87333.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; CP001363; ACY87333.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_001041123.1; NZ_CP043402.1.
DR AlphaFoldDB; D0ZQC5; -.
DR SMR; D0ZQC5; -.
DR EnsemblBacteria; ACY87333; ACY87333; STM14_0829.
DR KEGG; seo:STM14_0829; -.
DR PATRIC; fig|588858.6.peg.873; -.
DR HOGENOM; CLU_004790_0_0_6; -.
DR BioCyc; SENT588858:STM14_RS04165-MON; -.
DR Proteomes; UP000002695; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0071916; F:dipeptide transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015333; F:peptide:proton symporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd17346; MFS_DtpA_like; 1.
DR Gene3D; 1.20.1250.20; -; 1.
DR HAMAP; MF_01880; PTR2_DtpD_subfam; 1.
DR InterPro; IPR023777; AA/pep_transptr_DtpD.
DR InterPro; IPR005279; Dipep/tripep_permease.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR000109; POT_fam.
DR InterPro; IPR018456; PTR2_symporter_CS.
DR PANTHER; PTHR11654; PTHR11654; 1.
DR Pfam; PF00854; PTR2; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00924; yjdL_sub1_fam; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS01022; PTR2_1; 1.
DR PROSITE; PS01023; PTR2_2; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Peptide transport;
KW Protein transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..493
FT /note="Dipeptide permease D"
FT /id="PRO_0000395301"
FT TRANSMEM 14..34
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TRANSMEM 235..255
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TRANSMEM 267..287
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TRANSMEM 312..332
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TRANSMEM 344..364
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TRANSMEM 379..399
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TRANSMEM 413..433
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TRANSMEM 458..478
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
SQ SEQUENCE 493 AA; 53818 MW; 99BB72668CB70EBF CRC64;
MNKQASQPRA IYYVVALQIW EYFSFYGMRA LLILYLTNQL KYDDNHAYEL FSAYCSLVYV
TPILGGYLAD KVLGNRMAVM LGAFLMAIGH LVLGASEIAP TFLYLSLAII VCGYGLFKSN
ISCLLGELYQ PEDPRRDGGF SLLYAAGNIG SIVAPIACGY VQEEYSWAMG FALAAIGMLA
GLVIFLCGNR HFTHTTGVNK AVLCARNYLL PNWGWLLILL VAAPLLITVL FWKEWSVYAL
IVATAIGLVV LAKIYRQAQT AKQRKELGLI VTLTLFSMLF WAFAQQGGSS ISLYIDRFVN
RDILGYSVPT AMFQSVNAFA VMLCGVVLAW LVKESVSGNR TVRIWGKFAL GLGLMSAGFC
ILTLSARWSA AYGHSSMPLM VLGLAVMGFA ELFIDPVAMS QITRIDIPGV TGVLTGIYML
LSGAIANYLA GVIADQTSQS AFDASGAVNY AINAYVDVFE QITWGALACV GVVLLIWLYQ
SFKFKSRALA VES