DTPD_SALTY
ID DTPD_SALTY Reviewed; 493 AA.
AC Q7CQY0;
DT 13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Dipeptide permease D {ECO:0000255|HAMAP-Rule:MF_01880};
GN Name=dtpD {ECO:0000255|HAMAP-Rule:MF_01880}; OrderedLocusNames=STM0710;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Probable proton-dependent permease that transports
CC dipeptides. {ECO:0000255|HAMAP-Rule:MF_01880}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01880}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01880}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Proton-
CC dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. DtpD
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_01880}.
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DR EMBL; AE006468; AAL19654.1; -; Genomic_DNA.
DR RefSeq; NP_459695.1; NC_003197.2.
DR RefSeq; WP_001041123.1; NC_003197.2.
DR AlphaFoldDB; Q7CQY0; -.
DR SMR; Q7CQY0; -.
DR STRING; 99287.STM0710; -.
DR PaxDb; Q7CQY0; -.
DR EnsemblBacteria; AAL19654; AAL19654; STM0710.
DR GeneID; 1252230; -.
DR KEGG; stm:STM0710; -.
DR PATRIC; fig|99287.12.peg.742; -.
DR HOGENOM; CLU_004790_0_0_6; -.
DR OMA; GMMMGLW; -.
DR PhylomeDB; Q7CQY0; -.
DR BioCyc; SENT99287:STM0710-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0071916; F:dipeptide transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015333; F:peptide:proton symporter activity; IBA:GO_Central.
DR GO; GO:0042937; F:tripeptide transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd17346; MFS_DtpA_like; 1.
DR Gene3D; 1.20.1250.20; -; 1.
DR HAMAP; MF_01880; PTR2_DtpD_subfam; 1.
DR InterPro; IPR023777; AA/pep_transptr_DtpD.
DR InterPro; IPR005279; Dipep/tripep_permease.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR000109; POT_fam.
DR InterPro; IPR018456; PTR2_symporter_CS.
DR PANTHER; PTHR11654; PTHR11654; 1.
DR Pfam; PF00854; PTR2; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00924; yjdL_sub1_fam; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS01022; PTR2_1; 1.
DR PROSITE; PS01023; PTR2_2; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Peptide transport;
KW Protein transport; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..493
FT /note="Dipeptide permease D"
FT /id="PRO_0000395300"
FT TRANSMEM 14..34
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TRANSMEM 235..255
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TRANSMEM 267..287
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TRANSMEM 312..332
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TRANSMEM 344..364
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TRANSMEM 379..399
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TRANSMEM 413..433
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TRANSMEM 458..478
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
SQ SEQUENCE 493 AA; 53818 MW; 99BB72668CB70EBF CRC64;
MNKQASQPRA IYYVVALQIW EYFSFYGMRA LLILYLTNQL KYDDNHAYEL FSAYCSLVYV
TPILGGYLAD KVLGNRMAVM LGAFLMAIGH LVLGASEIAP TFLYLSLAII VCGYGLFKSN
ISCLLGELYQ PEDPRRDGGF SLLYAAGNIG SIVAPIACGY VQEEYSWAMG FALAAIGMLA
GLVIFLCGNR HFTHTTGVNK AVLCARNYLL PNWGWLLILL VAAPLLITVL FWKEWSVYAL
IVATAIGLVV LAKIYRQAQT AKQRKELGLI VTLTLFSMLF WAFAQQGGSS ISLYIDRFVN
RDILGYSVPT AMFQSVNAFA VMLCGVVLAW LVKESVSGNR TVRIWGKFAL GLGLMSAGFC
ILTLSARWSA AYGHSSMPLM VLGLAVMGFA ELFIDPVAMS QITRIDIPGV TGVLTGIYML
LSGAIANYLA GVIADQTSQS AFDASGAVNY AINAYVDVFE QITWGALACV GVVLLIWLYQ
SFKFKSRALA VES