DTPD_SHIFL
ID DTPD_SHIFL Reviewed; 493 AA.
AC Q83S84; Q7C2N9;
DT 13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 128.
DE RecName: Full=Dipeptide permease D {ECO:0000255|HAMAP-Rule:MF_01880};
GN Name=dtpD {ECO:0000255|HAMAP-Rule:MF_01880};
GN OrderedLocusNames=SF0588, S0601;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: Probable proton-dependent permease that transports
CC dipeptides. {ECO:0000255|HAMAP-Rule:MF_01880}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01880}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01880}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Proton-
CC dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. DtpD
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_01880}.
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DR EMBL; AE005674; AAN42230.1; -; Genomic_DNA.
DR EMBL; AE014073; AAP16103.1; -; Genomic_DNA.
DR RefSeq; NP_706523.1; NC_004337.2.
DR RefSeq; WP_001032694.1; NZ_WPGW01000035.1.
DR AlphaFoldDB; Q83S84; -.
DR SMR; Q83S84; -.
DR STRING; 198214.SF0588; -.
DR EnsemblBacteria; AAN42230; AAN42230; SF0588.
DR EnsemblBacteria; AAP16103; AAP16103; S0601.
DR GeneID; 1026075; -.
DR GeneID; 66671022; -.
DR KEGG; sfl:SF0588; -.
DR KEGG; sfx:S0601; -.
DR PATRIC; fig|198214.7.peg.683; -.
DR HOGENOM; CLU_004790_0_0_6; -.
DR OMA; GMMMGLW; -.
DR OrthoDB; 470322at2; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0071916; F:dipeptide transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015333; F:peptide:proton symporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd17346; MFS_DtpA_like; 1.
DR Gene3D; 1.20.1250.20; -; 1.
DR HAMAP; MF_01880; PTR2_DtpD_subfam; 1.
DR InterPro; IPR023777; AA/pep_transptr_DtpD.
DR InterPro; IPR005279; Dipep/tripep_permease.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR000109; POT_fam.
DR InterPro; IPR018456; PTR2_symporter_CS.
DR PANTHER; PTHR11654; PTHR11654; 1.
DR Pfam; PF00854; PTR2; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00924; yjdL_sub1_fam; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS01022; PTR2_1; 1.
DR PROSITE; PS01023; PTR2_2; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Peptide transport;
KW Protein transport; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..493
FT /note="Dipeptide permease D"
FT /id="PRO_0000395302"
FT TOPO_DOM 1..13
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TRANSMEM 14..34
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TOPO_DOM 35..48
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TOPO_DOM 70..77
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TOPO_DOM 99..100
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TOPO_DOM 122..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TOPO_DOM 159..166
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TOPO_DOM 188..211
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TOPO_DOM 233..234
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TRANSMEM 235..255
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TOPO_DOM 256..266
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TRANSMEM 267..287
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TOPO_DOM 288..311
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TRANSMEM 312..332
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TOPO_DOM 333..343
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TRANSMEM 344..364
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TOPO_DOM 365..378
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TRANSMEM 379..399
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TOPO_DOM 400..412
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TRANSMEM 413..433
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TOPO_DOM 434..461
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TRANSMEM 462..482
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT TOPO_DOM 483..493
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
SQ SEQUENCE 493 AA; 54145 MW; 955F59EDA08B5B7D CRC64;
MNKHASQPRA IYYVVALQIW EYFSFYGMRA LLILYLTNQL KYNDTHAYEL FSAYCSLVYV
TPILGGFLAD KVLGNRMAVM LGALLMAIGH VVLGASEIHP SFLYLSLAII VCGYGLFKSN
VSCLLGELYE PTDPRRDGGF SLMYAAGNVG SIIAPIACGY AQEEYSWAMG FGLAAVGMIA
GLVIFLCGNR HFTHTRGVNK KVLRATNFLL PNWGWLLVLL VATPALITVL FWKEWSVYAL
IVATIIGLGV LAKIYRKAEN QKQRKELGLI VTLTFFSMLF WAFAQQGGSS ISLYIDRFVN
RDMFGYTVPT AMFQSINAFA VMLCGVFLAW VVKESVAGNR TVRIWGKFAL GLGLMSAGFC
ILTLSARWSA MYGHSSLPLM VLGLAVMGFA ELFIDPVAMS QITRIEIPGV TGVLTGIYML
LSGAIANYLA GVIADQTSQA SFDASGAINY SINAYIEVFD QITWGALACV GLVLMIWLYQ
ALKFRNRALA LES
