ID   DTPT_LACHE              Reviewed;         497 AA.
AC   O07380;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Di-/tripeptide transporter;
GN   Name=dtpT;
OS   Lactobacillus helveticus (Lactobacillus suntoryeus).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=1587;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 15009 / DSM 20075 / BCRC 12936 / JCM 1120 / NBRC 15019 / NCIMB
RC   11971 / NRRL B-4526 / Lh12;
RX   PubMed=9172341; DOI=10.1128/aem.63.6.2213-2217.1997;
RA   Nakajima H., Hagting A., Kunji E.R.S., Poolman B., Konings W.N.;
RT   "Cloning and functional expression in Escherichia coli of the gene encoding
RT   the di- and tripeptide transport protein of Lactobacillus helveticus.";
RL   Appl. Environ. Microbiol. 63:2213-2217(1997).
CC   -!- FUNCTION: Proton-dependent uptake of di- or tri-peptides.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Proton-
CC       dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
CC       {ECO:0000305}.
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DR   EMBL; U77486; AAC45382.1; -; Genomic_DNA.
DR   AlphaFoldDB; O07380; -.
DR   SMR; O07380; -.
DR   STRING; 326425.lhe_0332; -.
DR   eggNOG; COG3104; Bacteria.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:1904680; F:peptide transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006857; P:oligopeptide transport; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR005279; Dipep/tripep_permease.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR000109; POT_fam.
DR   InterPro; IPR018456; PTR2_symporter_CS.
DR   PANTHER; PTHR11654; PTHR11654; 1.
DR   Pfam; PF00854; PTR2; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00924; yjdL_sub1_fam; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS01022; PTR2_1; 1.
DR   PROSITE; PS01023; PTR2_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Peptide transport; Protein transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..497
FT                   /note="Di-/tripeptide transporter"
FT                   /id="PRO_0000064321"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        227..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        294..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        321..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        372..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        452..472
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   497 AA;  55469 MW;  69C064FF9A0A26A5 CRC64;
     MRAILLFYMY YAVTKGGLGM SQTTAASIMS IYGSLVYLST LVGGWLSDRV WGSRKTVFYG
     GVLIMLGHIV LALPAGVTVL YRSIALIVVG TGLLKPNVSD MVGGLYSVED PRRDAGFSIF
     VFGINLGSII APWLVPWAAQ GFGVHIFGSQ LNFHAGFSLA AVGMFFGLVQ YVLGGKKYLS
     TESLTPNDPI DKGDLLNVIK WVVIIIIAIV AILAAMAGVG QLSVDNVITL LTILAIALPI
     YYFVMMFRSS KVTKIELGIH LLPVSLKNRL FFKKGYKRLK QIIQLELAIK RQSFIILIAL
     IIMASILIPN KVIIAKHLLK LVLLVFYWIG LNLIPFSTFV LSFLFLDYIK HMFKKEGEQA
     KKTKEKSRIH HGIEIPLFLR QLIINIFTLI ILEGETLFDE NGVEVNIAEH PVQGYTELNI
     NLLNKDSIDL WADWIQSVAK YLLNIMYTAD VIVIIIFYLV KMAALWWAWS YIPLSTVFVG
     YKYSGKDESL QAALEVL