DTPT_LACLC
ID DTPT_LACLC Reviewed; 497 AA.
AC P0C2U3; P36574; Q9CHM6;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 1.
DT 25-MAY-2022, entry version 67.
DE RecName: Full=Di-/tripeptide transporter;
GN Name=dtpT;
OS Lactococcus lactis subsp. cremoris (Streptococcus cremoris).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Lactococcus.
OX NCBI_TaxID=1359;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=NCDO 763 / ML3;
RX PubMed=8157671; DOI=10.1016/s0021-9258(19)78137-x;
RA Hagting A., Kunji E.R.S., Leenhouts K.J., Poolman B., Konings W.N.;
RT "The di- and tripeptide transport protein of Lactococcus lactis. A new type
RT of bacterial peptide transporter.";
RL J. Biol. Chem. 269:11391-11399(1994).
RN [2]
RP TOPOLOGY.
RX PubMed=9184160; DOI=10.1021/bi963068t;
RA Hagting A., van de Velde J., Poolman B., Konings W.N.;
RT "Membrane topology of the di- and tripeptide transport protein of
RT Lactococcus lactis.";
RL Biochemistry 36:6777-6785(1997).
CC -!- FUNCTION: Proton-dependent uptake of di- or tri-peptides.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Proton-
CC dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA20660.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; U05215; AAA20660.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_011835629.1; NZ_WJUW01000030.1.
DR AlphaFoldDB; P0C2U3; -.
DR SMR; P0C2U3; -.
DR GeneID; 61108961; -.
DR OMA; QMMGVWF; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:1904680; F:peptide transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006857; P:oligopeptide transport; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd17346; MFS_DtpA_like; 1.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR005279; Dipep/tripep_permease.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR000109; POT_fam.
DR InterPro; IPR018456; PTR2_symporter_CS.
DR PANTHER; PTHR11654; PTHR11654; 1.
DR Pfam; PF00854; PTR2; 1.
DR SUPFAM; SSF103473; SSF103473; 2.
DR TIGRFAMs; TIGR00924; yjdL_sub1_fam; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS01022; PTR2_1; 1.
DR PROSITE; PS01023; PTR2_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Peptide transport; Protein transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..497
FT /note="Di-/tripeptide transporter"
FT /id="PRO_0000285243"
FT TOPO_DOM 1..36
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:9184160"
FT TRANSMEM 37..55
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TOPO_DOM 56..64
FT /note="Extracellular"
FT /evidence="ECO:0000305|PubMed:9184160"
FT TRANSMEM 65..83
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TOPO_DOM 84..92
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:9184160"
FT TRANSMEM 93..111
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TOPO_DOM 112..115
FT /note="Extracellular"
FT /evidence="ECO:0000305|PubMed:9184160"
FT TRANSMEM 116..134
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TOPO_DOM 135..154
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:9184160"
FT TRANSMEM 155..173
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TOPO_DOM 174..181
FT /note="Extracellular"
FT /evidence="ECO:0000305|PubMed:9184160"
FT TRANSMEM 182..200
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TOPO_DOM 201..224
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:9184160"
FT TRANSMEM 225..243
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TOPO_DOM 244..254
FT /note="Extracellular"
FT /evidence="ECO:0000305|PubMed:9184160"
FT TRANSMEM 255..273
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TOPO_DOM 274..293
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:9184160"
FT TRANSMEM 294..312
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TOPO_DOM 313..335
FT /note="Extracellular"
FT /evidence="ECO:0000305|PubMed:9184160"
FT TRANSMEM 336..354
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TOPO_DOM 355..372
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:9184160"
FT TRANSMEM 373..391
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TOPO_DOM 392..425
FT /note="Extracellular"
FT /evidence="ECO:0000305|PubMed:9184160"
FT TRANSMEM 426..444
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TOPO_DOM 445..497
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:9184160"
SQ SEQUENCE 497 AA; 54791 MW; 07D95E41FDA39E67 CRC64;
MQNLNKTEKT FFGQPRGLLT LFQTEFWERF SYYGMRAILV YYLYALTTAD NAGLGLPKAQ
AMAIVSIYGA LVYLSTIVGG WVADRLLGAS RTIFLGGILI TLGHVALATP FGLSSLFVAL
FLIILGTGML KPNISNMVGH LYSKDDSRRD TGFNIFVVGI NMGSLIAPLI VGTVGQGVNY
HLGFSLAAIG MIFALFAYWY GRLRHFPEIG REPSNPMDAK AKRNFIITLT IVLIVALIGF
FLIYQASPAN FINNFINVLS IIGIVVPIIY FVMMFTSKKV ESDERRKLTA YIPLFLSAIV
FWAIEEQSST IIAVWGESRS NLNPTWFGFT FHIDPSWYQL LNPLFIVLLS PIFVRIWNKL
GDRQPSTIVK FGLGLMLTGA SYLIMTLPGL LNGTSGRASA LWLVLMFAVQ MAGELLVSPV
GLSVSTKLAP VAFQSQMMAM WFLADSTSQA INAQITPIFK AATEVHFFAI TGIIGIIVGI
ILLIIKKPIL KLMGDVR
