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DTPT_LACLM
ID   DTPT_LACLM              Reviewed;         497 AA.
AC   A2RMA8;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Di-/tripeptide transporter;
GN   Name=dtpT; OrderedLocusNames=llmg_1865;
OS   Lactococcus lactis subsp. cremoris (strain MG1363).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus; Lactococcus cremoris subsp. cremoris.
OX   NCBI_TaxID=416870;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MG1363;
RX   PubMed=17307855; DOI=10.1128/jb.01768-06;
RA   Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C.,
RA   Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P.,
RA   van Sinderen D., Kok J.;
RT   "The complete genome sequence of the lactic acid bacterial paradigm
RT   Lactococcus lactis subsp. cremoris MG1363.";
RL   J. Bacteriol. 189:3256-3270(2007).
CC   -!- FUNCTION: Proton-dependent uptake of di- or tri-peptides.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Proton-
CC       dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
CC       {ECO:0000305}.
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DR   EMBL; AM406671; CAL98435.1; -; Genomic_DNA.
DR   RefSeq; WP_011835629.1; NZ_WJVF01000021.1.
DR   AlphaFoldDB; A2RMA8; -.
DR   SMR; A2RMA8; -.
DR   STRING; 416870.llmg_1865; -.
DR   EnsemblBacteria; CAL98435; CAL98435; llmg_1865.
DR   GeneID; 61108961; -.
DR   KEGG; llm:llmg_1865; -.
DR   eggNOG; COG3104; Bacteria.
DR   HOGENOM; CLU_004790_0_1_9; -.
DR   OMA; QMMGVWF; -.
DR   PhylomeDB; A2RMA8; -.
DR   BioCyc; LLAC416870:LLMG_RS09340-MON; -.
DR   Proteomes; UP000000364; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:1904680; F:peptide transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006857; P:oligopeptide transport; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd17346; MFS_DtpA_like; 1.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR005279; Dipep/tripep_permease.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR000109; POT_fam.
DR   InterPro; IPR018456; PTR2_symporter_CS.
DR   PANTHER; PTHR11654; PTHR11654; 1.
DR   Pfam; PF00854; PTR2; 1.
DR   SUPFAM; SSF103473; SSF103473; 2.
DR   TIGRFAMs; TIGR00924; yjdL_sub1_fam; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS01022; PTR2_1; 1.
DR   PROSITE; PS01023; PTR2_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Peptide transport; Protein transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..497
FT                   /note="Di-/tripeptide transporter"
FT                   /id="PRO_0000285244"
FT   TOPO_DOM        1..36
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        37..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        56..64
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        65..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        84..92
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        93..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        112..115
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        116..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        135..154
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        155..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        174..181
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        182..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        201..224
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        225..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        244..254
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        255..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        274..293
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        294..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        313..335
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        336..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        355..372
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        373..391
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        392..425
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        426..444
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        445..497
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   497 AA;  54791 MW;  07D95E41FDA39E67 CRC64;
     MQNLNKTEKT FFGQPRGLLT LFQTEFWERF SYYGMRAILV YYLYALTTAD NAGLGLPKAQ
     AMAIVSIYGA LVYLSTIVGG WVADRLLGAS RTIFLGGILI TLGHVALATP FGLSSLFVAL
     FLIILGTGML KPNISNMVGH LYSKDDSRRD TGFNIFVVGI NMGSLIAPLI VGTVGQGVNY
     HLGFSLAAIG MIFALFAYWY GRLRHFPEIG REPSNPMDAK AKRNFIITLT IVLIVALIGF
     FLIYQASPAN FINNFINVLS IIGIVVPIIY FVMMFTSKKV ESDERRKLTA YIPLFLSAIV
     FWAIEEQSST IIAVWGESRS NLNPTWFGFT FHIDPSWYQL LNPLFIVLLS PIFVRIWNKL
     GDRQPSTIVK FGLGLMLTGA SYLIMTLPGL LNGTSGRASA LWLVLMFAVQ MAGELLVSPV
     GLSVSTKLAP VAFQSQMMAM WFLADSTSQA INAQITPIFK AATEVHFFAI TGIIGIIVGI
     ILLIIKKPIL KLMGDVR
 
 
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