ID   DTWD1_PONAB             Reviewed;         304 AA.
AC   Q5RCQ0;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=tRNA-uridine aminocarboxypropyltransferase 1 {ECO:0000305};
DE            EC=2.5.1.25 {ECO:0000250|UniProtKB:Q8N5C7};
DE   AltName: Full=DTW domain-containing protein 1 {ECO:0000305};
GN   Name=DTWD1 {ECO:0000250|UniProtKB:Q8N5C7};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine
CC       (acp3U) at position 20 in the D-loop of several cytoplasmic tRNAs
CC       (acp3U(20)). {ECO:0000250|UniProtKB:Q8N5C7}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3-
CC         amino-3-carboxypropyl]uridine in tRNA + H(+) + S-methyl-5'-
CC         thioadenosine; Xref=Rhea:RHEA:62432, Rhea:RHEA-COMP:13339, Rhea:RHEA-
CC         COMP:16092, ChEBI:CHEBI:15378, ChEBI:CHEBI:17509, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:65315, ChEBI:CHEBI:82930; EC=2.5.1.25;
CC         Evidence={ECO:0000250|UniProtKB:Q8N5C7};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8N5C7}.
CC   -!- DOMAIN: Contains 1 DXTW motif.
CC   -!- SIMILARITY: Belongs to the TDD superfamily. DTWD1 family.
CC       {ECO:0000305}.
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DR   EMBL; CR858219; CAH90457.1; -; mRNA.
DR   RefSeq; NP_001125235.1; NM_001131763.1.
DR   RefSeq; XP_009248090.1; XM_009249815.1.
DR   RefSeq; XP_009248091.1; XM_009249816.1.
DR   AlphaFoldDB; Q5RCQ0; -.
DR   STRING; 9601.ENSPPYP00000007326; -.
DR   Ensembl; ENSPPYT00000007628; ENSPPYP00000007326; ENSPPYG00000006464.
DR   GeneID; 100172129; -.
DR   KEGG; pon:100172129; -.
DR   CTD; 56986; -.
DR   eggNOG; KOG3795; Eukaryota.
DR   GeneTree; ENSGT00940000153766; -.
DR   HOGENOM; CLU_069451_0_1_1; -.
DR   InParanoid; Q5RCQ0; -.
DR   OMA; VNAWGLN; -.
DR   OrthoDB; 824721at2759; -.
DR   TreeFam; TF324733; -.
DR   Proteomes; UP000001595; Chromosome 15.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0016432; F:tRNA-uridine aminocarboxypropyltransferase activity; ISS:UniProtKB.
DR   GO; GO:0006400; P:tRNA modification; ISS:UniProtKB.
DR   InterPro; IPR005636; DTW.
DR   Pfam; PF03942; DTW; 1.
DR   SMART; SM01144; DTW; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Nucleus; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase; tRNA processing.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N5C7"
FT   CHAIN           2..304
FT                   /note="tRNA-uridine aminocarboxypropyltransferase 1"
FT                   /id="PRO_0000308214"
FT   MOTIF           206..209
FT                   /note="DXTW"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N5C7"
SQ   SEQUENCE   304 AA;  35231 MW;  A1B17966D7C8A0DA CRC64;
     MSLNPPIFLK RSEENNSKFV ETKQSQTTSI ASEDPLQNLC LASQEVLQKA QQSGRSKCLK
     CGGSRMFYCY TCYVPVENVP IEQIPLVKLP LKIDIIKHPN ETDGKSTAIH AKLLAPEFVN
     IYTYPCIPEY EEKDHEVALV FPGPQSISIK DISFHLQKRI QNNVRGKNDD PDKPSFKRKR
     AEEQEFCDLN DSKCKGTTLK KIIFIDSTWN QTNKIFTDER LQGLLQVELK TRKTCFWRHQ
     KGKPDTFLST IEAIYYFLVD YHTDILKEKY RGQYDNLLFF YSFMYQLIKN AKCSGDKETG
     KLTH