DTX11_ARATH
ID DTX11_ARATH Reviewed; 487 AA.
AC F4HZH9; Q9XI53;
DT 14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Protein DETOXIFICATION 11 {ECO:0000303|PubMed:11739388};
DE Short=AtDTX11 {ECO:0000303|PubMed:11739388};
DE AltName: Full=Multidrug and toxic compound extrusion protein 11 {ECO:0000305};
DE Short=MATE protein 11 {ECO:0000305};
GN Name=DTX11 {ECO:0000303|PubMed:11739388};
GN OrderedLocusNames=At1g15160 {ECO:0000312|Araport:AT1G15160};
GN ORFNames=F9L1.10 {ECO:0000312|EMBL:AAD39648.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11739388; DOI=10.1074/jbc.m108777200;
RA Li L., He Z., Pandey G.K., Tsuchiya T., Luan S.;
RT "Functional cloning and characterization of a plant efflux carrier for
RT multidrug and heavy metal detoxification.";
RL J. Biol. Chem. 277:5360-5368(2002).
RN [4]
RP GENE FAMILY.
RX PubMed=12603313; DOI=10.1046/j.1432-1033.2003.03418.x;
RA Hvorup R.N., Winnen B., Chang A.B., Jiang Y., Zhou X.F., Saier M.H. Jr.;
RT "The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter
RT superfamily.";
RL Eur. J. Biochem. 270:799-813(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD39648.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC007591; AAD39648.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE29275.1; -; Genomic_DNA.
DR PIR; E86285; E86285.
DR RefSeq; NP_172968.1; NM_101384.2.
DR AlphaFoldDB; F4HZH9; -.
DR SMR; F4HZH9; -.
DR STRING; 3702.AT1G15160.1; -.
DR PaxDb; F4HZH9; -.
DR PRIDE; F4HZH9; -.
DR EnsemblPlants; AT1G15160.1; AT1G15160.1; AT1G15160.
DR GeneID; 838081; -.
DR Gramene; AT1G15160.1; AT1G15160.1; AT1G15160.
DR KEGG; ath:AT1G15160; -.
DR Araport; AT1G15160; -.
DR TAIR; locus:2037848; AT1G15160.
DR eggNOG; KOG1347; Eukaryota.
DR HOGENOM; CLU_012893_1_0_1; -.
DR InParanoid; F4HZH9; -.
DR OMA; RYTAWLI; -.
DR OrthoDB; 743037at2759; -.
DR PRO; PR:F4HZH9; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; F4HZH9; baseline and differential.
DR Genevisible; F4HZH9; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR Pfam; PF01554; MatE; 2.
DR TIGRFAMs; TIGR00797; matE; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..487
FT /note="Protein DETOXIFICATION 11"
FT /id="PRO_0000434054"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 264..284
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 293..313
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 330..350
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 377..397
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 412..432
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 435..455
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 487 AA; 52765 MW; A10B235BC21167F0 CRC64;
MEDAESTTKD PVDRVEKVTW RDLQDGSFTA ELKKLICFAA PMAAVVITQS MLQIITMVIV
GHLGRLSLAS ASFAISFCNV TGFSFIMGLS CALDTLSGQA YGAKLYRKLG VQAYTAMFCL
TLVCLPLSLL WFNMGKLLVI LGQDPSIAHE AGRFAAWLIP GLFAYAVLQP LTRYFKNQSL
ITPLLITSCV VFCLHVPLCW LLVYKSGLDH IGGALALSLS YWLYAIFLGS FMYFSSACSE
TRAPLTMEIF EGVREFIKYA LPSAAMLCLE WWSYELIILL SGLLPNPQLE TSVLSVCLQT
LSMTYSIPLA IAAAASTRIS NELGAGNSRA AHIVVYAAMS LAVVDALMVG TSLLAGKNLL
GQVFSSDKNT IDYVAKMAPL VSISLILDSL QGVLSGVASG CGWQHIGAYI NFGAFYLWGI
PIAASLAFWV HLKGVGLWIG IIAGAVLQTL LLALVTGCIN WENQAREARK RMAVAHESEL
TESELPF
