DTX14_ARATH
ID DTX14_ARATH Reviewed; 485 AA.
AC Q9C994;
DT 14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Protein DETOXIFICATION 14 {ECO:0000303|PubMed:11739388};
DE Short=AtDTX14 {ECO:0000303|PubMed:11739388};
DE AltName: Full=Multidrug and toxic compound extrusion protein 14 {ECO:0000305};
DE Short=MATE protein 14 {ECO:0000305};
GN Name=DTX14 {ECO:0000303|PubMed:11739388};
GN OrderedLocusNames=At1g71140 {ECO:0000312|Araport:AT1G71140};
GN ORFNames=F23N20.13 {ECO:0000312|EMBL:AAG51691.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11739388; DOI=10.1074/jbc.m108777200;
RA Li L., He Z., Pandey G.K., Tsuchiya T., Luan S.;
RT "Functional cloning and characterization of a plant efflux carrier for
RT multidrug and heavy metal detoxification.";
RL J. Biol. Chem. 277:5360-5368(2002).
RN [4]
RP GENE FAMILY.
RX PubMed=12603313; DOI=10.1046/j.1432-1033.2003.03418.x;
RA Hvorup R.N., Winnen B., Chang A.B., Jiang Y., Zhou X.F., Saier M.H. Jr.;
RT "The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter
RT superfamily.";
RL Eur. J. Biochem. 270:799-813(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC016972; AAG51691.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE35165.1; -; Genomic_DNA.
DR PIR; A96736; A96736.
DR RefSeq; NP_177270.1; NM_105783.3.
DR PDB; 5Y50; X-ray; 2.60 A; A=20-473.
DR PDBsum; 5Y50; -.
DR AlphaFoldDB; Q9C994; -.
DR SMR; Q9C994; -.
DR IntAct; Q9C994; 20.
DR STRING; 3702.AT1G71140.1; -.
DR TCDB; 2.A.66.1.52; the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily.
DR iPTMnet; Q9C994; -.
DR PaxDb; Q9C994; -.
DR PRIDE; Q9C994; -.
DR ProteomicsDB; 220716; -.
DR EnsemblPlants; AT1G71140.1; AT1G71140.1; AT1G71140.
DR GeneID; 843454; -.
DR Gramene; AT1G71140.1; AT1G71140.1; AT1G71140.
DR KEGG; ath:AT1G71140; -.
DR Araport; AT1G71140; -.
DR TAIR; locus:2026311; AT1G71140.
DR eggNOG; KOG1347; Eukaryota.
DR HOGENOM; CLU_012893_1_0_1; -.
DR InParanoid; Q9C994; -.
DR OMA; GMKEFFR; -.
DR OrthoDB; 743037at2759; -.
DR PhylomeDB; Q9C994; -.
DR PRO; PR:Q9C994; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C994; baseline and differential.
DR Genevisible; Q9C994; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0000325; C:plant-type vacuole; HDA:TAIR.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR GO; GO:0042908; P:xenobiotic transport; IDA:TAIR.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR Pfam; PF01554; MatE; 2.
DR TIGRFAMs; TIGR00797; matE; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..485
FT /note="Protein DETOXIFICATION 14"
FT /id="PRO_0000434057"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 259..279
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TRANSMEM 329..349
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 372..392
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 405..425
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 432..452
FT /note="Helical"
FT /evidence="ECO:0000255"
FT HELIX 22..56
FT /evidence="ECO:0007829|PDB:5Y50"
FT HELIX 60..76
FT /evidence="ECO:0007829|PDB:5Y50"
FT HELIX 78..85
FT /evidence="ECO:0007829|PDB:5Y50"
FT HELIX 88..97
FT /evidence="ECO:0007829|PDB:5Y50"
FT HELIX 101..127
FT /evidence="ECO:0007829|PDB:5Y50"
FT HELIX 129..136
FT /evidence="ECO:0007829|PDB:5Y50"
FT HELIX 140..152
FT /evidence="ECO:0007829|PDB:5Y50"
FT HELIX 154..172
FT /evidence="ECO:0007829|PDB:5Y50"
FT HELIX 176..198
FT /evidence="ECO:0007829|PDB:5Y50"
FT HELIX 206..229
FT /evidence="ECO:0007829|PDB:5Y50"
FT HELIX 231..233
FT /evidence="ECO:0007829|PDB:5Y50"
FT TURN 234..236
FT /evidence="ECO:0007829|PDB:5Y50"
FT HELIX 243..246
FT /evidence="ECO:0007829|PDB:5Y50"
FT HELIX 248..275
FT /evidence="ECO:0007829|PDB:5Y50"
FT HELIX 276..278
FT /evidence="ECO:0007829|PDB:5Y50"
FT STRAND 279..281
FT /evidence="ECO:0007829|PDB:5Y50"
FT HELIX 282..319
FT /evidence="ECO:0007829|PDB:5Y50"
FT HELIX 323..350
FT /evidence="ECO:0007829|PDB:5Y50"
FT HELIX 352..355
FT /evidence="ECO:0007829|PDB:5Y50"
FT HELIX 356..358
FT /evidence="ECO:0007829|PDB:5Y50"
FT HELIX 363..371
FT /evidence="ECO:0007829|PDB:5Y50"
FT HELIX 373..395
FT /evidence="ECO:0007829|PDB:5Y50"
FT HELIX 404..411
FT /evidence="ECO:0007829|PDB:5Y50"
FT HELIX 414..422
FT /evidence="ECO:0007829|PDB:5Y50"
FT TURN 423..425
FT /evidence="ECO:0007829|PDB:5Y50"
FT HELIX 428..452
FT /evidence="ECO:0007829|PDB:5Y50"
FT HELIX 456..467
FT /evidence="ECO:0007829|PDB:5Y50"
SQ SEQUENCE 485 AA; 52425 MW; 6D95DBDDCEE6CC59 CRC64;
MDSAEKGLLV VSDREEVNKK DGFLRETKKL SYIAGPMIAV NSSMYVLQVI SIMMVGHLGE
LFLSSTAIAV SFCSVTGFSV VFGLASALET LCGQANGAKQ YEKLGVHTYT GIVSLFLVCI
PLSLLWTYIG DILSLIGQDA MVAQEAGKFA TWLIPALFGY ATLQPLVRFF QAQSLILPLV
MSSVSSLCIH IVLCWSLVFK FGLGSLGAAI AIGVSYWLNV TVLGLYMTFS SSCSKSRATI
SMSLFEGMGE FFRFGIPSAS MICLEWWSFE FLVLLSGILP NPKLEASVLS VCLSTQSSLY
QIPESLGAAA STRVANELGA GNPKQARMAV YTAMVITGVE SIMVGAIVFG ARNVFGYLFS
SETEVVDYVK SMAPLLSLSV IFDALHAALS GVARGSGRQD IGAYVNLAAY YLFGIPTAIL
LAFGFKMRGR GLWIGITVGS CVQAVLLGLI VILTNWKKQA RKARERVMGD EYEEKESEEE
HEYIS
