DTX15_ARATH
ID DTX15_ARATH Reviewed; 480 AA.
AC F4IHU9; O80785;
DT 14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Protein DETOXIFICATION 15 {ECO:0000303|PubMed:11739388};
DE Short=AtDTX15 {ECO:0000303|PubMed:11739388};
DE AltName: Full=Multidrug and toxic compound extrusion protein 15 {ECO:0000305};
DE Short=MATE protein 15 {ECO:0000305};
GN Name=DTX15 {ECO:0000303|PubMed:11739388};
GN OrderedLocusNames=At2g34360 {ECO:0000312|Araport:AT2G34360};
GN ORFNames=F13P17.20 {ECO:0000312|EMBL:AAC27412.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11739388; DOI=10.1074/jbc.m108777200;
RA Li L., He Z., Pandey G.K., Tsuchiya T., Luan S.;
RT "Functional cloning and characterization of a plant efflux carrier for
RT multidrug and heavy metal detoxification.";
RL J. Biol. Chem. 277:5360-5368(2002).
RN [4]
RP GENE FAMILY.
RX PubMed=12603313; DOI=10.1046/j.1432-1033.2003.03418.x;
RA Hvorup R.N., Winnen B., Chang A.B., Jiang Y., Zhou X.F., Saier M.H. Jr.;
RT "The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter
RT superfamily.";
RL Eur. J. Biochem. 270:799-813(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC27412.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC004481; AAC27412.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC08964.1; -; Genomic_DNA.
DR PIR; T02324; T02324.
DR RefSeq; NP_180983.4; NM_128988.5.
DR AlphaFoldDB; F4IHU9; -.
DR SMR; F4IHU9; -.
DR STRING; 3702.AT2G34360.1; -.
DR PaxDb; F4IHU9; -.
DR PRIDE; F4IHU9; -.
DR EnsemblPlants; AT2G34360.1; AT2G34360.1; AT2G34360.
DR GeneID; 817999; -.
DR Gramene; AT2G34360.1; AT2G34360.1; AT2G34360.
DR KEGG; ath:AT2G34360; -.
DR Araport; AT2G34360; -.
DR TAIR; locus:2040839; AT2G34360.
DR eggNOG; KOG1347; Eukaryota.
DR HOGENOM; CLU_012893_1_4_1; -.
DR InParanoid; F4IHU9; -.
DR OMA; CHLGVCW; -.
DR OrthoDB; 743037at2759; -.
DR PRO; PR:F4IHU9; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; F4IHU9; baseline and differential.
DR Genevisible; F4IHU9; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR Pfam; PF01554; MatE; 2.
DR TIGRFAMs; TIGR00797; matE; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..480
FT /note="Protein DETOXIFICATION 15"
FT /id="PRO_0000434058"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 208..228
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 255..275
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..314
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 360..380
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 396..416
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 428..448
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 480 AA; 52187 MW; F3BA8A315D3D5CAB CRC64;
MREEREDMLS WPLIGEKEKR SRFVKEEVEK QLLLSGPLIA VSLLQFCLQI ISVMFVGHLG
SLPLSAASIA TSFASVTGFT FLMGTASAMD TVCGQSYGAK MYGMLGIQMQ RAMLVLTLLS
VPLSIVWANT EHFLVFFGQD KSIAHLSGSY ARFMIPSIFA YGLLQCLNRF LQAQNNVIPV
VICSGVTTSL HVIICWVLVL KSGLGFRGAA VANAISYWLN VILLSCYVKF SPSCSLTWTG
FSKEARRDII PFMKLVIPSA FMVCSLEMWS FELLVLSSGL LPNPVLETSC PRTVWMIPFG
LSGAASTRVS NELGSGNPKG AKLAVRVVLS FSIVESILVG TVLILIRKIW GFAYSSDPEV
VSHVASMLPI LALGHSLDSF QTVLSGVARG CGWQKIGAFV NLGSYYLVGV PFGLLLGFHF
HVGGRGLWLG IICALIVQGV CLSLITFFTN WDEEVKKATS RAKSSSEVKE FAVDNGSILV
