ID   DTX16_ARATH             Reviewed;         486 AA.
AC   Q9FHB6;
DT   14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 139.
DE   RecName: Full=Protein DETOXIFICATION 16 {ECO:0000303|PubMed:11739388};
DE            Short=AtDTX16 {ECO:0000303|PubMed:11739388};
DE   AltName: Full=Multidrug and toxic compound extrusion protein 16 {ECO:0000305};
DE            Short=MATE protein 16 {ECO:0000305};
GN   Name=DTX16 {ECO:0000303|PubMed:11739388};
GN   OrderedLocusNames=At5g52450 {ECO:0000312|Araport:AT5G52450};
GN   ORFNames=K24M7.20 {ECO:0000312|EMBL:BAB10542.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA   Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT   features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT   clones.";
RL   DNA Res. 7:31-63(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=11739388; DOI=10.1074/jbc.m108777200;
RA   Li L., He Z., Pandey G.K., Tsuchiya T., Luan S.;
RT   "Functional cloning and characterization of a plant efflux carrier for
RT   multidrug and heavy metal detoxification.";
RL   J. Biol. Chem. 277:5360-5368(2002).
RN   [5]
RP   GENE FAMILY.
RX   PubMed=12603313; DOI=10.1046/j.1432-1033.2003.03418.x;
RA   Hvorup R.N., Winnen B., Chang A.B., Jiang Y., Zhou X.F., Saier M.H. Jr.;
RT   "The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter
RT   superfamily.";
RL   Eur. J. Biochem. 270:799-813(2003).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
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DR   EMBL; AB019226; BAB10542.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED96215.1; -; Genomic_DNA.
DR   EMBL; AY046054; AAK76728.1; -; mRNA.
DR   EMBL; AY079316; AAL85047.1; -; mRNA.
DR   RefSeq; NP_200058.1; NM_124624.4.
DR   AlphaFoldDB; Q9FHB6; -.
DR   SMR; Q9FHB6; -.
DR   STRING; 3702.AT5G52450.1; -.
DR   iPTMnet; Q9FHB6; -.
DR   PaxDb; Q9FHB6; -.
DR   PRIDE; Q9FHB6; -.
DR   ProteomicsDB; 221932; -.
DR   EnsemblPlants; AT5G52450.1; AT5G52450.1; AT5G52450.
DR   GeneID; 835321; -.
DR   Gramene; AT5G52450.1; AT5G52450.1; AT5G52450.
DR   KEGG; ath:AT5G52450; -.
DR   Araport; AT5G52450; -.
DR   TAIR; locus:2156737; AT5G52450.
DR   eggNOG; KOG1347; Eukaryota.
DR   HOGENOM; CLU_012893_1_0_1; -.
DR   InParanoid; Q9FHB6; -.
DR   OMA; CITRLGT; -.
DR   OrthoDB; 743037at2759; -.
DR   PhylomeDB; Q9FHB6; -.
DR   PRO; PR:Q9FHB6; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9FHB6; baseline and differential.
DR   Genevisible; Q9FHB6; AT.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0000325; C:plant-type vacuole; HDA:TAIR.
DR   GO; GO:0009536; C:plastid; HDA:TAIR.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0009624; P:response to nematode; HEP:TAIR.
DR   GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR   CDD; cd13132; MATE_eukaryotic; 1.
DR   InterPro; IPR045069; MATE_euk.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..486
FT                   /note="Protein DETOXIFICATION 16"
FT                   /id="PRO_0000434059"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        207..227
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        259..279
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        288..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        331..351
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        365..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        401..421
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        433..453
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   486 AA;  52473 MW;  365A0B661DE142BC CRC64;
     MRDDRERGEG DLSWPLIGEK SSVKEEVKKQ LWLSGPLIAV SLLQFCLQVI SVMFVGHLGS
     LPLSAASIAT SFASVTGFSF LMGTASALDT LCGQAYGAKK YGMLGIQMQR AMFVLTLASI
     PLSIIWANTE HLLVFFGQNK SIATLAGSYA KFMIPSIFAY GLLQCFNRFL QAQNNVFPVV
     FCSGVTTSLH VLLCWVLVFK SGLGFQGAAL ANSISYWLNV VLLFCYVKFS PSCSLTWTGF
     SKEALRDILP FLRLAVPSAL MVCLEMWSFE LLVLLSGLLP NPVLETSVLS ICLNTSGTMW
     MIPFGLSGAA STRISNELGA GNPKVAKLAV RVVICIAVAE SIVIGSVLIL IRNIWGLAYS
     SELEVVSYVA SMMPILALGN FLDSLQCVLS GVARGCGWQK IGAIINLGSY YLVGVPSGLL
     LAFHFHVGGR GLWLGIICAL VVQVFGLGLV TIFTNWDEEA KKATNRIESS SSVKDFAVDD
     RSVVVF