DTX17_ARATH
ID DTX17_ARATH Reviewed; 476 AA.
AC Q9C9U1; Q8LF49;
DT 14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Protein DETOXIFICATION 17 {ECO:0000303|PubMed:11739388};
DE Short=AtDTX17 {ECO:0000303|PubMed:11739388};
DE AltName: Full=Multidrug and toxic compound extrusion protein 17 {ECO:0000305};
DE Short=MATE protein 17 {ECO:0000305};
GN Name=DTX17 {ECO:0000303|PubMed:11739388};
GN OrderedLocusNames=At1g73700 {ECO:0000312|Araport:AT1G73700};
GN ORFNames=F25P22.12 {ECO:0000312|EMBL:AAG52084.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11739388; DOI=10.1074/jbc.m108777200;
RA Li L., He Z., Pandey G.K., Tsuchiya T., Luan S.;
RT "Functional cloning and characterization of a plant efflux carrier for
RT multidrug and heavy metal detoxification.";
RL J. Biol. Chem. 277:5360-5368(2002).
RN [5]
RP GENE FAMILY.
RX PubMed=12603313; DOI=10.1046/j.1432-1033.2003.03418.x;
RA Hvorup R.N., Winnen B., Chang A.B., Jiang Y., Zhou X.F., Saier M.H. Jr.;
RT "The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter
RT superfamily.";
RL Eur. J. Biochem. 270:799-813(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000305}.
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DR EMBL; AC012679; AAG52084.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE35499.1; -; Genomic_DNA.
DR EMBL; AY085051; AAM61608.1; -; mRNA.
DR PIR; B96764; B96764.
DR RefSeq; NP_177511.1; NM_106029.2.
DR AlphaFoldDB; Q9C9U1; -.
DR SMR; Q9C9U1; -.
DR STRING; 3702.AT1G73700.1; -.
DR iPTMnet; Q9C9U1; -.
DR PaxDb; Q9C9U1; -.
DR PRIDE; Q9C9U1; -.
DR EnsemblPlants; AT1G73700.1; AT1G73700.1; AT1G73700.
DR GeneID; 843705; -.
DR Gramene; AT1G73700.1; AT1G73700.1; AT1G73700.
DR KEGG; ath:AT1G73700; -.
DR Araport; AT1G73700; -.
DR TAIR; locus:2027834; AT1G73700.
DR eggNOG; KOG1347; Eukaryota.
DR HOGENOM; CLU_012893_1_0_1; -.
DR InParanoid; Q9C9U1; -.
DR OMA; IWANTEQ; -.
DR OrthoDB; 743037at2759; -.
DR PhylomeDB; Q9C9U1; -.
DR PRO; PR:Q9C9U1; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C9U1; baseline and differential.
DR Genevisible; Q9C9U1; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR Pfam; PF01554; MatE; 2.
DR TIGRFAMs; TIGR00797; matE; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..476
FT /note="Protein DETOXIFICATION 17"
FT /id="PRO_0000434060"
FT TRANSMEM 29..51
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 252..272
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 286..306
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 363..383
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 405..425
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 431..451
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 55
FT /note="H -> Y (in Ref. 3; AAM61608)"
FT /evidence="ECO:0000305"
FT CONFLICT 395
FT /note="G -> V (in Ref. 3; AAM61608)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 476 AA; 51054 MW; 717048350835AE1A CRC64;
MEDGVTPPLL ITEKDTTMIR VKEEVKKQLW LSAPLIGVSL LQYSLQVISV MFVGHLGSLP
LSAASIATSF ASVTGFTFLL GTASALETLC GQAYGAKLYG KLGIQMQRAM FVLLILSVPL
SIIWANTEQI LVLVHQDKSI ASVAGSYAKY MIPSLFAYGL LQCINRFLQA QNNVFPVFVC
SGITTCLHLL LCWLFVLKTG LGYRGAALAI SVSYWFNVIL LSCYVKFSPS CSHSWTGFSK
EAFQELYDFS KIAFPSAVMV CLELWSFELL VLASGLLPNP VLETSVLSIC LNTSLTIWQI
SVGLGGAASI RVSNELGAGN PQVAKLAVYV IVGIAVAEGI VVVTVLLSIR KILGHAFSSD
PKIIAYAASM IPIVACGNFL DGLQCVLSGV ARGCGWQKIG ACVNLGSYYL VGVPLGLLLG
FHFHIGGRGL WLGIVTALSV QVLCLSLVTI FTNWDKEAKK ATNRVGSSDD KDGDVQ
