DTX20_ARATH
ID DTX20_ARATH Reviewed; 491 AA.
AC F4HPH2;
DT 14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Protein DETOXIFICATION 20 {ECO:0000303|PubMed:11739388};
DE Short=AtDTX20 {ECO:0000303|PubMed:11739388};
DE AltName: Full=Multidrug and toxic compound extrusion protein 20 {ECO:0000305};
DE Short=MATE protein 20 {ECO:0000305};
GN Name=DTX20 {ECO:0000303|PubMed:11739388};
GN OrderedLocusNames=At1g33100 {ECO:0000312|Araport:AT1G33100};
GN ORFNames=F9L11.27 {ECO:0000312|EMBL:AC006424},
GN T9L6.18 {ECO:0000312|EMBL:AC021045};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11739388; DOI=10.1074/jbc.m108777200;
RA Li L., He Z., Pandey G.K., Tsuchiya T., Luan S.;
RT "Functional cloning and characterization of a plant efflux carrier for
RT multidrug and heavy metal detoxification.";
RL J. Biol. Chem. 277:5360-5368(2002).
RN [4]
RP GENE FAMILY.
RX PubMed=12603313; DOI=10.1046/j.1432-1033.2003.03418.x;
RA Hvorup R.N., Winnen B., Chang A.B., Jiang Y., Zhou X.F., Saier M.H. Jr.;
RT "The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter
RT superfamily.";
RL Eur. J. Biochem. 270:799-813(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000305}.
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DR EMBL; AC006424; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC021045; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002684; AEE31564.1; -; Genomic_DNA.
DR RefSeq; NP_174586.2; NM_103044.3.
DR AlphaFoldDB; F4HPH2; -.
DR SMR; F4HPH2; -.
DR IntAct; F4HPH2; 36.
DR STRING; 3702.AT1G33100.1; -.
DR PaxDb; F4HPH2; -.
DR PRIDE; F4HPH2; -.
DR ProteomicsDB; 220720; -.
DR EnsemblPlants; AT1G33100.1; AT1G33100.1; AT1G33100.
DR GeneID; 840206; -.
DR Gramene; AT1G33100.1; AT1G33100.1; AT1G33100.
DR KEGG; ath:AT1G33100; -.
DR Araport; AT1G33100; -.
DR TAIR; locus:2038016; AT1G33100.
DR eggNOG; KOG1347; Eukaryota.
DR HOGENOM; CLU_012893_1_4_1; -.
DR InParanoid; F4HPH2; -.
DR OMA; CISINAL; -.
DR OrthoDB; 743037at2759; -.
DR PRO; PR:F4HPH2; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; F4HPH2; baseline and differential.
DR Genevisible; F4HPH2; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR Pfam; PF01554; MatE; 2.
DR TIGRFAMs; TIGR00797; matE; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..491
FT /note="Protein DETOXIFICATION 20"
FT /id="PRO_0000434061"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 265..285
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 296..316
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..357
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 381..401
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 413..433
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 438..458
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 491 AA; 53505 MW; 2421D223332E97BD CRC64;
MAGRGGELTE ALVKKTGREE EDELGMKEKV WIESKKLWVV AAPAIFTRYS TFGVSMVTQA
FIGHLGPTEL AAYSITFTIL LRFSNGILLG MAGALGTLCG QAYGAKQYQM LGIYLQRSWI
VLTGGTICLM PVFIFAGPIL LALGQEERIV RVARVLALWV IGINFSFVPS FTCQMFLQAQ
SKNKIISYVT AVSLGLHVFF SWLLVAHFNF GITGAMTSML IAFWLPIIVQ LLYVTCGGCK
DTWRGFSMLA FKDLWPVLKL SLSSGGMLCL ELWYNSVLVL LTGNLKNAEV ALDALAICIS
INALEMMIAL GFLAAVSVRV SNELGSGNPK GAKFATLIAV FTSLSIGIVL FFVFLFLRGR
ISYIFTTSEA VAAEVADLSP LLAFSILLNS VQPVLSGVAI GAGWQGYVAY VNLACYYLVG
IPIGVILGYV VGLQVKGVWI GMLFGIFVQT CVLTVMTLRT DWDQQVSTSL RNINRWVVPE
SRDANQISSE E
