DTX22_ARATH
ID DTX22_ARATH Reviewed; 494 AA.
AC F4HPH1; Q0WPQ7; Q9MAN5;
DT 14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Protein DETOXIFICATION 22 {ECO:0000303|PubMed:11739388};
DE Short=AtDTX22 {ECO:0000303|PubMed:11739388};
DE AltName: Full=Multidrug and toxic compound extrusion protein 22 {ECO:0000305};
DE Short=MATE protein 22 {ECO:0000305};
GN Name=DTX22 {ECO:0000303|PubMed:11739388};
GN OrderedLocusNames=At1g33090 {ECO:0000312|Araport:AT1G33090};
GN ORFNames=F9L11.23 {ECO:0000312|EMBL:AAF31289.1},
GN T9L6.17 {ECO:0000312|EMBL:AC021045};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11739388; DOI=10.1074/jbc.m108777200;
RA Li L., He Z., Pandey G.K., Tsuchiya T., Luan S.;
RT "Functional cloning and characterization of a plant efflux carrier for
RT multidrug and heavy metal detoxification.";
RL J. Biol. Chem. 277:5360-5368(2002).
RN [5]
RP GENE FAMILY.
RX PubMed=12603313; DOI=10.1046/j.1432-1033.2003.03418.x;
RA Hvorup R.N., Winnen B., Chang A.B., Jiang Y., Zhou X.F., Saier M.H. Jr.;
RT "The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter
RT superfamily.";
RL Eur. J. Biochem. 270:799-813(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF31289.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC006424; AAF31289.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC021045; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002684; AEE31563.1; -; Genomic_DNA.
DR EMBL; AK229005; BAF00892.1; -; mRNA.
DR RefSeq; NP_174585.1; NM_103043.2.
DR AlphaFoldDB; F4HPH1; -.
DR SMR; F4HPH1; -.
DR STRING; 3702.AT1G33090.1; -.
DR iPTMnet; F4HPH1; -.
DR PaxDb; F4HPH1; -.
DR PRIDE; F4HPH1; -.
DR ProteomicsDB; 221882; -.
DR EnsemblPlants; AT1G33090.1; AT1G33090.1; AT1G33090.
DR GeneID; 840205; -.
DR Gramene; AT1G33090.1; AT1G33090.1; AT1G33090.
DR KEGG; ath:AT1G33090; -.
DR Araport; AT1G33090; -.
DR TAIR; locus:2037980; AT1G33090.
DR eggNOG; KOG1347; Eukaryota.
DR HOGENOM; CLU_012893_1_4_1; -.
DR InParanoid; F4HPH1; -.
DR OMA; CTICIMP; -.
DR OrthoDB; 743037at2759; -.
DR PRO; PR:F4HPH1; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; F4HPH1; baseline and differential.
DR Genevisible; F4HPH1; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR Pfam; PF01554; MatE; 2.
DR TIGRFAMs; TIGR00797; matE; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..494
FT /note="Protein DETOXIFICATION 22"
FT /id="PRO_0000434063"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 217..237
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..288
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 299..319
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 340..360
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 384..404
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 416..436
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 441..461
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 35
FT /note="I -> V (in Ref. 3; BAF00892)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 494 AA; 53727 MW; D45A49BEE1308FBF CRC64;
MAGEGGELTA ALLKKTTENG GEENDELGLK EKVWIESKKL WVVAAPSIFT KFSTYGVSLV
TQGFVGHIGP TELAAYSITF TVLLRFSNGI LLGMASALGT LCGQAYGAKQ YHMLGIHLQR
SWIVLTGCTI CIMPIFIFSG PILLALGQED HIVRVARVIA LWLIAINFTF VPAFTCQIFL
QSQSKNKIIA YVSAVTLGLH VFFSWLLVVH FNFGITGAMT STLVAFWMPN IVQLLYVTSG
GCKDTWRGFT MLAFKDLWPV FKLSLSSGGM VCLELWYNSI LVLLTGNLKN AEVAIDALAI
CINVNALQMM IALGFLAAVS VRVSNELGRG NPEGAKFATI VAVFTSLSIG LVLFFVFLFL
RGRISYIFTT SEAVAAEVAD LSPLLAFSIL LNSVQPVLSG VAVGAGWQGY VAYINLACYY
LLGIPVGLVL GYVVGLQVKG VWIGMLFGIF VQTCVLTIMT LRTDWDQQVS TSLKNINRWV
VPESRDANQI SSEE
