DTX24_ARATH
ID DTX24_ARATH Reviewed; 500 AA.
AC F4J158; Q9SS64;
DT 14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Protein DETOXIFICATION 24 {ECO:0000303|PubMed:11739388};
DE Short=AtDTX24 {ECO:0000303|PubMed:11739388};
DE AltName: Full=Multidrug and toxic compound extrusion protein 24 {ECO:0000305};
DE Short=MATE protein 24 {ECO:0000305};
GN Name=DTX24 {ECO:0000303|PubMed:11739388};
GN OrderedLocusNames=At3g03620 {ECO:0000312|Araport:AT3G03620};
GN ORFNames=T12J13.10 {ECO:0000312|EMBL:AAF03470.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14993207; DOI=10.1101/gr.1515604;
RA Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA Weissenbach J., Salanoubat M.;
RT "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT combined approach to evaluate and improve Arabidopsis genome annotation.";
RL Genome Res. 14:406-413(2004).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11739388; DOI=10.1074/jbc.m108777200;
RA Li L., He Z., Pandey G.K., Tsuchiya T., Luan S.;
RT "Functional cloning and characterization of a plant efflux carrier for
RT multidrug and heavy metal detoxification.";
RL J. Biol. Chem. 277:5360-5368(2002).
RN [5]
RP GENE FAMILY.
RX PubMed=12603313; DOI=10.1046/j.1432-1033.2003.03418.x;
RA Hvorup R.N., Winnen B., Chang A.B., Jiang Y., Zhou X.F., Saier M.H. Jr.;
RT "The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter
RT superfamily.";
RL Eur. J. Biochem. 270:799-813(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF03470.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC009327; AAF03470.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE73963.1; -; Genomic_DNA.
DR EMBL; CP002686; ANM65488.1; -; Genomic_DNA.
DR EMBL; BX823254; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_001327451.1; NM_001337478.1.
DR RefSeq; NP_187012.2; NM_111233.4.
DR AlphaFoldDB; F4J158; -.
DR SMR; F4J158; -.
DR STRING; 3702.AT3G03620.1; -.
DR PaxDb; F4J158; -.
DR PRIDE; F4J158; -.
DR ProteomicsDB; 221884; -.
DR EnsemblPlants; AT3G03620.1; AT3G03620.1; AT3G03620.
DR EnsemblPlants; AT3G03620.2; AT3G03620.2; AT3G03620.
DR GeneID; 821204; -.
DR Gramene; AT3G03620.1; AT3G03620.1; AT3G03620.
DR Gramene; AT3G03620.2; AT3G03620.2; AT3G03620.
DR KEGG; ath:AT3G03620; -.
DR Araport; AT3G03620; -.
DR TAIR; locus:2096379; AT3G03620.
DR eggNOG; KOG1347; Eukaryota.
DR HOGENOM; CLU_012893_1_4_1; -.
DR InParanoid; F4J158; -.
DR OMA; IIYKTDW; -.
DR OrthoDB; 743037at2759; -.
DR PRO; PR:F4J158; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; F4J158; baseline and differential.
DR Genevisible; F4J158; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR Pfam; PF01554; MatE; 2.
DR TIGRFAMs; TIGR00797; matE; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..500
FT /note="Protein DETOXIFICATION 24"
FT /id="PRO_0000434065"
FT TRANSMEM 48..67
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..286
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 298..318
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 342..362
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 384..404
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 411..431
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 441..461
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 173
FT /note="F -> L (in Ref. 3; BX823254)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 500 AA; 55297 MW; 100DE883F1F48B82 CRC64;
MSTQEEMEER LLREGSDAEG QSNNRESIYL RTKVWSEVNK MWRIALPSSL FRMTSFGSII
VAQAFIGHSS ELGLAAYALL QSTFIRFLYG LMGGMSSATE TLCGQAYGAE QYHTMGIYLQ
RSWIVDMAVT TLFLPFIVLA GPILRLLGQN VEITKTVDEI YPWMIPYVYS LIFTMTIQMY
LQAQMRNAIV GVLSTLSLAL DLVVTWWCVS VMGMGIGGAL LGLNVGSWAM VLAEFVYIFG
GWCPFTWTGF SIAAFVDLIP MLKLSISSGF MICLEYWYMS ILVLMAGYTK DAKIAISAFS
ICQYIYTWEL NICLGFLGAA CVRVANELGK GDAHAVRFSI KVILTISTLM GVIFSALCLA
FCGRISYLFS NSDEVSDAVN DLSVILAVSI LLNSIQPILS GVAVGAGMQS IVAVVNLASY
YAIGIPLGLI LTYVFHLGVK GLWSGMLAGI AIQTIILCYI IYKTDWELEV KRTCERMKVW
SLKPSNEESN PIIREESRSK
