DTX25_ARATH
ID DTX25_ARATH Reviewed; 497 AA.
AC Q8L616; Q9FN81;
DT 14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Protein DETOXIFICATION 25 {ECO:0000303|PubMed:11739388};
DE Short=AtDTX25 {ECO:0000303|PubMed:11739388};
DE AltName: Full=Multidrug and toxic compound extrusion protein 25 {ECO:0000305};
DE Short=MATE protein 25 {ECO:0000305};
GN Name=DTX25 {ECO:0000303|PubMed:11739388};
GN OrderedLocusNames=At5g17700 {ECO:0000312|Araport:AT5G17700};
GN ORFNames=MVA3.5 {ECO:0000312|EMBL:BAB09569.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9405937; DOI=10.1093/dnares/4.4.291;
RA Kotani H., Nakamura Y., Sato S., Kaneko T., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. II. Sequence
RT features of the regions of 1,044,062 bp covered by thirteen physically
RT assigned P1 clones.";
RL DNA Res. 4:291-300(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11739388; DOI=10.1074/jbc.m108777200;
RA Li L., He Z., Pandey G.K., Tsuchiya T., Luan S.;
RT "Functional cloning and characterization of a plant efflux carrier for
RT multidrug and heavy metal detoxification.";
RL J. Biol. Chem. 277:5360-5368(2002).
RN [5]
RP GENE FAMILY.
RX PubMed=12603313; DOI=10.1046/j.1432-1033.2003.03418.x;
RA Hvorup R.N., Winnen B., Chang A.B., Jiang Y., Zhou X.F., Saier M.H. Jr.;
RT "The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter
RT superfamily.";
RL Eur. J. Biochem. 270:799-813(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB09569.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB006706; BAB09569.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED92457.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM68684.1; -; Genomic_DNA.
DR EMBL; AY099666; AAM20517.1; -; mRNA.
DR EMBL; BT000259; AAN15578.1; -; mRNA.
DR RefSeq; NP_001330412.1; NM_001343520.1.
DR RefSeq; NP_197272.2; NM_121776.5.
DR AlphaFoldDB; Q8L616; -.
DR SMR; Q8L616; -.
DR IntAct; Q8L616; 6.
DR STRING; 3702.AT5G17700.1; -.
DR PaxDb; Q8L616; -.
DR PRIDE; Q8L616; -.
DR ProteomicsDB; 224284; -.
DR EnsemblPlants; AT5G17700.1; AT5G17700.1; AT5G17700.
DR EnsemblPlants; AT5G17700.2; AT5G17700.2; AT5G17700.
DR GeneID; 831637; -.
DR Gramene; AT5G17700.1; AT5G17700.1; AT5G17700.
DR Gramene; AT5G17700.2; AT5G17700.2; AT5G17700.
DR KEGG; ath:AT5G17700; -.
DR Araport; AT5G17700; -.
DR TAIR; locus:2175916; AT5G17700.
DR eggNOG; KOG1347; Eukaryota.
DR HOGENOM; CLU_012893_1_4_1; -.
DR InParanoid; Q8L616; -.
DR OMA; INIFRFG; -.
DR OrthoDB; 743037at2759; -.
DR PhylomeDB; Q8L616; -.
DR PRO; PR:Q8L616; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q8L616; baseline and differential.
DR Genevisible; Q8L616; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR Pfam; PF01554; MatE; 2.
DR TIGRFAMs; TIGR00797; matE; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..497
FT /note="Protein DETOXIFICATION 25"
FT /id="PRO_0000434066"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..177
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..236
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 261..281
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 291..311
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 339..359
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 381..401
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 416..436
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 438..458
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 497 AA; 54619 MW; FB45094754C999D5 CRC64;
MSGGGGEMEE RLLNGSETEQ RRESLYLRKK IWSEVRKMWR IALPSTLFRV MSFGCVVVAQ
AFIGHSSETG LAAYALLQST FIRFIYGIMA GMSSATETLC GQAYGAEQYH MMGIYLQRSW
IVDTFIATLF VPFIVLAGPI LRLLGQNVVI SETVDEIYPW VIPYLYSIVF TMTMQMYLQA
QMKNAIIGIL STLALVLDIA ATWWCVSVMG MGIHGALLGL NISSWSVAIA EFVYVFGGWC
PHTWTGFSTA AFLDLIPMLK LSISSGFMLC LEYWYMSIIV LMSGYAKDAN IAISAFSICQ
YIYSWEMNIC FGLMGAACVR VANELGKGDA DAVRFSIKVV LVVSAVIGVI CSALCLAFGG
QISYLFSDSQ AVSDAVADLS IVLSISILFN IIQPILSGVA IGAGMQSMVA LVNLASYYAI
GVPLGVLLVY VFNFGIKGLW SGMLAGVGIQ TLILCYVIYK TDWELEVKKT NERMKTWTLN
LPAVQSTTIS TRDEERK
