DTX27_ARATH
ID DTX27_ARATH Reviewed; 486 AA.
AC Q9FKQ1;
DT 14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Protein DETOXIFICATION 27 {ECO:0000303|PubMed:11739388};
DE Short=AtDTX27 {ECO:0000303|PubMed:11739388};
DE AltName: Full=Multidrug and toxic compound extrusion protein 27 {ECO:0000305};
DE Short=MATE protein 27 {ECO:0000305};
GN Name=DTX27 {ECO:0000303|PubMed:11739388};
GN OrderedLocusNames=At5g65380 {ECO:0000312|Araport:AT5G65380};
GN ORFNames=MNA5.11 {ECO:0000312|EMBL:BAB11560.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9679202; DOI=10.1093/dnares/5.2.131;
RA Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence
RT features of the regions of 1,381,565 bp covered by twenty one physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:131-145(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11739388; DOI=10.1074/jbc.m108777200;
RA Li L., He Z., Pandey G.K., Tsuchiya T., Luan S.;
RT "Functional cloning and characterization of a plant efflux carrier for
RT multidrug and heavy metal detoxification.";
RL J. Biol. Chem. 277:5360-5368(2002).
RN [5]
RP GENE FAMILY.
RX PubMed=12603313; DOI=10.1046/j.1432-1033.2003.03418.x;
RA Hvorup R.N., Winnen B., Chang A.B., Jiang Y., Zhou X.F., Saier M.H. Jr.;
RT "The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter
RT superfamily.";
RL Eur. J. Biochem. 270:799-813(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000305}.
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DR EMBL; AB011479; BAB11560.1; -; Genomic_DNA.
DR EMBL; CP002688; AED98045.1; -; Genomic_DNA.
DR EMBL; AF375456; AAK53040.1; -; mRNA.
DR EMBL; AY143960; AAN28899.1; -; mRNA.
DR RefSeq; NP_201341.1; NM_125936.4.
DR AlphaFoldDB; Q9FKQ1; -.
DR SMR; Q9FKQ1; -.
DR STRING; 3702.AT5G65380.1; -.
DR PaxDb; Q9FKQ1; -.
DR PRIDE; Q9FKQ1; -.
DR ProteomicsDB; 221933; -.
DR EnsemblPlants; AT5G65380.1; AT5G65380.1; AT5G65380.
DR GeneID; 836663; -.
DR Gramene; AT5G65380.1; AT5G65380.1; AT5G65380.
DR KEGG; ath:AT5G65380; -.
DR Araport; AT5G65380; -.
DR TAIR; locus:2168210; AT5G65380.
DR eggNOG; KOG1347; Eukaryota.
DR HOGENOM; CLU_012893_1_4_1; -.
DR InParanoid; Q9FKQ1; -.
DR OMA; RIDWREM; -.
DR OrthoDB; 743037at2759; -.
DR PhylomeDB; Q9FKQ1; -.
DR PRO; PR:Q9FKQ1; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FKQ1; baseline and differential.
DR Genevisible; Q9FKQ1; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR Pfam; PF01554; MatE; 2.
DR TIGRFAMs; TIGR00797; matE; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..486
FT /note="Protein DETOXIFICATION 27"
FT /id="PRO_0000434068"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..94
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..236
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TRANSMEM 299..319
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 349..369
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 384..404
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 407..427
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 439..461
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 486 AA; 52972 MW; BB20E3EDBCA3B5E9 CRC64;
MRGGDGEEGS ESRVALLKSP HTAEEDGEGL KDRILVETKK LWQIVGPAIF SRVTTYSMLV
ITQAFAGHLG DLELAAISIV NNVTVGFNFG LLLGMASALE TLCGQAFGAK KYHMLGVYMQ
RSWIVLFFCC VLLLPTYIFT TPVLKFLGQP DDIAELSGVV AIWVIPLHFA FTLSFPLQRF
LQCQLKNRVT AYAAAVALVV HILVCWLFVD GLKLGVVGTV ATISISWWVN VLILLVYSTC
GGCPLTWTGL SSEALTGLWE FLKLSASSGV MLCLENWYYR ILIIMTGNLQ NARIAVDSLS
ICMAINGWEM MIPLAFFAGT GVRVANELGA GNGKGARFAT IVSVTQSLII GLFFWVLIML
LHNQIAWIFS SSVAVLDAVN KLSLLLAFTV LLNSVQPVLS GVAVGSGWQS YVAYINLGCY
YCIGVPLGFL MGWGFKLGVM GIWGGMIFGG TAVQTMILSF ITMRCDWEKE AQKASARINK
WSNTIK
