DTX28_ARATH
ID DTX28_ARATH Reviewed; 491 AA.
AC Q9FNC1;
DT 14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Protein DETOXIFICATION 28 {ECO:0000303|PubMed:11739388};
DE Short=AtDTX28 {ECO:0000303|PubMed:11739388};
DE AltName: Full=Multidrug and toxic compound extrusion protein 28 {ECO:0000305};
DE Short=MATE protein 28 {ECO:0000305};
GN Name=DTX28 {ECO:0000303|PubMed:11739388};
GN OrderedLocusNames=At5g44050 {ECO:0000312|Araport:AT5G44050};
GN ORFNames=MRH10.16 {ECO:0000312|EMBL:BAB09065.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9405937; DOI=10.1093/dnares/4.4.291;
RA Kotani H., Nakamura Y., Sato S., Kaneko T., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. II. Sequence
RT features of the regions of 1,044,062 bp covered by thirteen physically
RT assigned P1 clones.";
RL DNA Res. 4:291-300(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11739388; DOI=10.1074/jbc.m108777200;
RA Li L., He Z., Pandey G.K., Tsuchiya T., Luan S.;
RT "Functional cloning and characterization of a plant efflux carrier for
RT multidrug and heavy metal detoxification.";
RL J. Biol. Chem. 277:5360-5368(2002).
RN [4]
RP GENE FAMILY.
RX PubMed=12603313; DOI=10.1046/j.1432-1033.2003.03418.x;
RA Hvorup R.N., Winnen B., Chang A.B., Jiang Y., Zhou X.F., Saier M.H. Jr.;
RT "The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter
RT superfamily.";
RL Eur. J. Biochem. 270:799-813(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000305}.
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DR EMBL; AB006703; BAB09065.1; -; Genomic_DNA.
DR EMBL; CP002688; AED95052.1; -; Genomic_DNA.
DR RefSeq; NP_199218.1; NM_123772.3.
DR AlphaFoldDB; Q9FNC1; -.
DR SMR; Q9FNC1; -.
DR IntAct; Q9FNC1; 2.
DR STRING; 3702.AT5G44050.1; -.
DR PaxDb; Q9FNC1; -.
DR PRIDE; Q9FNC1; -.
DR ProteomicsDB; 222221; -.
DR EnsemblPlants; AT5G44050.1; AT5G44050.1; AT5G44050.
DR GeneID; 834428; -.
DR Gramene; AT5G44050.1; AT5G44050.1; AT5G44050.
DR KEGG; ath:AT5G44050; -.
DR Araport; AT5G44050; -.
DR TAIR; locus:2172477; AT5G44050.
DR eggNOG; KOG1347; Eukaryota.
DR HOGENOM; CLU_012893_1_4_1; -.
DR InParanoid; Q9FNC1; -.
DR OMA; DVAEWSG; -.
DR OrthoDB; 743037at2759; -.
DR PhylomeDB; Q9FNC1; -.
DR PRO; PR:Q9FNC1; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FNC1; baseline and differential.
DR Genevisible; Q9FNC1; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR Pfam; PF01554; MatE; 2.
DR TIGRFAMs; TIGR00797; matE; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..491
FT /note="Protein DETOXIFICATION 28"
FT /id="PRO_0000434069"
FT TRANSMEM 47..67
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..212
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..248
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TRANSMEM 302..322
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 352..372
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 387..407
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 414..434
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 444..464
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 491 AA; 54720 MW; 68D48DF840790401 CRC64;
MGERDDEAEG ILEKAKIPLL KDQNVAEEEN GEIKKEIWLE TKKLWRIVGP AIFTRVTTNL
IFVITQAFAG HLGELELAAI SIVNNVIIGF NYSLFIGMAT ALETLCGQAF GAKKYDMFGV
YLQRSWIVLF LFSILLLPMY IFATPILKFM GQPDDIAELS GIISVWAIPT HFSFAFFFPI
NRFLQCQLKN SVIAISSGVS LVVHIFVCWL FVYVLELGVI GTIATANVSW WLNVFILFTY
TTCGGCPLTW TGFSMESFTR LWEFTKLSAS SGIMVCLENW YYRMLIVMTG NLEDARIDVD
SMSICMSING LEMMVPLAFF AGTSVRVANE LGAGNGKRAR FAMIISVTQS LIIGIIISVL
IYFLLDQIGW MFSSSETVLK AVNNLSILLS FAILLNSVQP VLSGVAVGSG WQSLVAFINL
GCYYFIGLPL GIVMGWMFKF GVKGIWAGMI FGGTMVQTLI LIFITMRCDW EKEAQNAKVR
VNKWSVSDAR K
