ID   DTX30_ARATH             Reviewed;         498 AA.
AC   Q9LS19;
DT   14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Protein DETOXIFICATION 30 {ECO:0000303|PubMed:11739388};
DE            Short=AtDTX30 {ECO:0000303|PubMed:11739388};
DE   AltName: Full=Multidrug and toxic compound extrusion protein 30 {ECO:0000305};
DE            Short=MATE protein 30 {ECO:0000305};
GN   Name=DTX30 {ECO:0000303|PubMed:11739388};
GN   OrderedLocusNames=At5g38030 {ECO:0000312|Araport:AT5G38030};
GN   ORFNames=F16F17.3 {ECO:0000312|EMBL:BAA97535.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RA   Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL   Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=11739388; DOI=10.1074/jbc.m108777200;
RA   Li L., He Z., Pandey G.K., Tsuchiya T., Luan S.;
RT   "Functional cloning and characterization of a plant efflux carrier for
RT   multidrug and heavy metal detoxification.";
RL   J. Biol. Chem. 277:5360-5368(2002).
RN   [5]
RP   GENE FAMILY.
RX   PubMed=12603313; DOI=10.1046/j.1432-1033.2003.03418.x;
RA   Hvorup R.N., Winnen B., Chang A.B., Jiang Y., Zhou X.F., Saier M.H. Jr.;
RT   "The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter
RT   superfamily.";
RL   Eur. J. Biochem. 270:799-813(2003).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
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DR   EMBL; AB028606; BAA97535.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED94259.1; -; Genomic_DNA.
DR   EMBL; AF372972; AAK50109.1; -; mRNA.
DR   EMBL; BT002707; AAO11623.1; -; mRNA.
DR   RefSeq; NP_198619.1; NM_123162.4.
DR   AlphaFoldDB; Q9LS19; -.
DR   SMR; Q9LS19; -.
DR   IntAct; Q9LS19; 3.
DR   STRING; 3702.AT5G38030.1; -.
DR   PaxDb; Q9LS19; -.
DR   PRIDE; Q9LS19; -.
DR   ProteomicsDB; 224298; -.
DR   EnsemblPlants; AT5G38030.1; AT5G38030.1; AT5G38030.
DR   GeneID; 833782; -.
DR   Gramene; AT5G38030.1; AT5G38030.1; AT5G38030.
DR   KEGG; ath:AT5G38030; -.
DR   Araport; AT5G38030; -.
DR   TAIR; locus:2144421; AT5G38030.
DR   eggNOG; KOG1347; Eukaryota.
DR   HOGENOM; CLU_012893_1_4_1; -.
DR   InParanoid; Q9LS19; -.
DR   OMA; WYLMAVI; -.
DR   OrthoDB; 743037at2759; -.
DR   PhylomeDB; Q9LS19; -.
DR   PRO; PR:Q9LS19; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9LS19; baseline and differential.
DR   Genevisible; Q9LS19; AT.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR   GO; GO:0005774; C:vacuolar membrane; IBA:GO_Central.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0010252; P:auxin homeostasis; IMP:TAIR.
DR   GO; GO:0009624; P:response to nematode; HEP:TAIR.
DR   GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR   CDD; cd13132; MATE_eukaryotic; 1.
DR   InterPro; IPR045069; MATE_euk.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..498
FT                   /note="Protein DETOXIFICATION 30"
FT                   /id="PRO_0000434071"
FT   TRANSMEM        64..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        136..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        161..181
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        227..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        277..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        302..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        349..369
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        393..413
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        419..439
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        447..467
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   498 AA;  53646 MW;  191D8942B36D3928 CRC64;
     MEEDKILTET LLSAAEEPPA LPFSSVEDIP PITTVGGFVK EFNVEVKKLW YLAGPAIFMS
     ITQYSLGAAT QVFAGHISTI ALAAVSVENS VIAGFSFGVM LGMGSALETL CGQAFGAGKL
     SMLGVYLQRS WVILNVTAVI LSLLYIFAAP ILAFIGQTPA ISSATGIFSI YMIPQIFAYA
     VNYPTAKFLQ SQSKIMVMAA ISAVALVLHV LLTWFVIEGL QWGTAGLAVV LNASWWFIVV
     AQLVYIFSGT CGEAWSGFSW EAFHNLWSFV RLSLASAVML CLEVWYLMAV ILFAGYLKNA
     EISVAALSIC MNILGWTAMI AIGMNAAVSV RVSNELGAKH PRTAKFSLLV AVITSTVIGL
     AISIALLIFR DKYPSLFVGD EEVIIVVKDL TPILAVSIVI NNVQPVLSGV AVGAGWQAVV
     AYVNIVCYYV FGIPFGLLLG YKLNFGVMGI WCGMLTGTVV QTIVLTWMIC RTNWDTEAAM
     AEGRIREWGG EVSDQLLN