DTX32_ARATH
ID DTX32_ARATH Reviewed; 515 AA.
AC F4I4Q3; Q9LR32;
DT 14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Protein DETOXIFICATION 32 {ECO:0000303|PubMed:11739388};
DE Short=AtDTX32 {ECO:0000303|PubMed:11739388};
DE AltName: Full=Multidrug and toxic compound extrusion protein 32 {ECO:0000305};
DE Short=MATE protein 32 {ECO:0000305};
GN Name=DTX32 {ECO:0000303|PubMed:11739388};
GN OrderedLocusNames=At1g23300 {ECO:0000312|Araport:AT1G23300};
GN ORFNames=F26F24.14 {ECO:0000312|EMBL:AAF87016.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11739388; DOI=10.1074/jbc.m108777200;
RA Li L., He Z., Pandey G.K., Tsuchiya T., Luan S.;
RT "Functional cloning and characterization of a plant efflux carrier for
RT multidrug and heavy metal detoxification.";
RL J. Biol. Chem. 277:5360-5368(2002).
RN [4]
RP GENE FAMILY.
RX PubMed=12603313; DOI=10.1046/j.1432-1033.2003.03418.x;
RA Hvorup R.N., Winnen B., Chang A.B., Jiang Y., Zhou X.F., Saier M.H. Jr.;
RT "The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter
RT superfamily.";
RL Eur. J. Biochem. 270:799-813(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF87016.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC005292; AAF87016.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE30369.1; -; Genomic_DNA.
DR PIR; A86367; A86367.
DR RefSeq; NP_173744.1; NM_102179.2.
DR AlphaFoldDB; F4I4Q3; -.
DR SMR; F4I4Q3; -.
DR IntAct; F4I4Q3; 3.
DR STRING; 3702.AT1G23300.1; -.
DR iPTMnet; F4I4Q3; -.
DR PaxDb; F4I4Q3; -.
DR PRIDE; F4I4Q3; -.
DR EnsemblPlants; AT1G23300.1; AT1G23300.1; AT1G23300.
DR GeneID; 838939; -.
DR Gramene; AT1G23300.1; AT1G23300.1; AT1G23300.
DR KEGG; ath:AT1G23300; -.
DR Araport; AT1G23300; -.
DR TAIR; locus:2028115; AT1G23300.
DR eggNOG; KOG1347; Eukaryota.
DR HOGENOM; CLU_012893_1_4_1; -.
DR InParanoid; F4I4Q3; -.
DR OMA; WPIMVAF; -.
DR OrthoDB; 743037at2759; -.
DR PRO; PR:F4I4Q3; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; F4I4Q3; baseline and differential.
DR Genevisible; F4I4Q3; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005774; C:vacuolar membrane; IBA:GO_Central.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR Pfam; PF01554; MatE; 2.
DR TIGRFAMs; TIGR00797; matE; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..515
FT /note="Protein DETOXIFICATION 32"
FT /id="PRO_0000434073"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..323
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 347..367
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 392..412
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 418..438
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 448..468
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 488..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..25
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 515 AA; 56362 MW; 0448F702E8901EDE CRC64;
METLNVDHED TISSEQEHRA HTKSDTDMPP ISGGRDFIRQ FAAESKKLWW LAGPAIFTSF
CQYSLGAVTQ ILAGHVNTLA LAAVSIQNSV ISGFSVGIML GMGSALATLC GQAYGAGQLE
MMGIYLQRSW IILNSCALLL CLFYVFATPL LSLLGQSPEI SKAAGKFSLW MIPQLFAYAV
NFATAKFLQA QSKVIAMAVI AATVLLQHTL LSWLLMLKLR WGMAGGAVVL NMSWWLIDVT
QIVYICGGSS GRAWSGLSWM AFKNLRGFAR LSLASAVMVC LEVWYFMALI LFAGYLKNPQ
VSVAALSICM NILGWPIMVA FGFNAAVSVR ESNELGAEHP RRAKFLLIVA MITSVSIGIV
ISVTLIVLRD KYPAMFSDDE EVRVLVKQLT PLLALTIVIN NIQPVLSGVA VGAGWQGIVA
YVNIGCYYLC GIPIGLVLGY KMELGVKGIW TGMLTGTVVQ TSVLLFIIYR TNWKKEASLA
EARIKKWGDQ SNKREEIDLC EEDENNSNGE NNHRK
