DTX39_ARATH
ID DTX39_ARATH Reviewed; 507 AA.
AC Q940N9; B9DGV2; F4JKC0; F4JKC2; O49714; Q8LDZ2;
DT 14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Protein DETOXIFICATION 39 {ECO:0000303|PubMed:11739388};
DE Short=AtDTX39 {ECO:0000303|PubMed:11739388};
DE AltName: Full=Multidrug and toxic compound extrusion protein 39 {ECO:0000305};
DE Short=MATE protein 39 {ECO:0000305};
GN Name=DTX39 {ECO:0000303|PubMed:11739388};
GN OrderedLocusNames=At4g21910 {ECO:0000312|Araport:AT4G21910};
GN ORFNames=T8O5.120 {ECO:0000312|EMBL:CAA17158.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=cv. Columbia;
RX PubMed=19423640; DOI=10.1093/dnares/dsp009;
RA Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M.,
RA Shinozaki K.;
RT "Analysis of multiple occurrences of alternative splicing events in
RT Arabidopsis thaliana using novel sequenced full-length cDNAs.";
RL DNA Res. 16:155-164(2009).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11739388; DOI=10.1074/jbc.m108777200;
RA Li L., He Z., Pandey G.K., Tsuchiya T., Luan S.;
RT "Functional cloning and characterization of a plant efflux carrier for
RT multidrug and heavy metal detoxification.";
RL J. Biol. Chem. 277:5360-5368(2002).
RN [7]
RP GENE FAMILY.
RX PubMed=12603313; DOI=10.1046/j.1432-1033.2003.03418.x;
RA Hvorup R.N., Winnen B., Chang A.B., Jiang Y., Zhou X.F., Saier M.H. Jr.;
RT "The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter
RT superfamily.";
RL Eur. J. Biochem. 270:799-813(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q940N9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q940N9-2; Sequence=VSP_057897;
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA17158.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB79146.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL021890; CAA17158.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161556; CAB79146.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE84525.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE84526.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE84527.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE84528.2; -; Genomic_DNA.
DR EMBL; AY054235; AAL06895.1; -; mRNA.
DR EMBL; AY133521; AAM91351.1; -; mRNA.
DR EMBL; AK316904; BAH19610.1; -; mRNA.
DR EMBL; AK317293; BAH19969.1; -; mRNA.
DR EMBL; AY085718; AAM62936.1; -; mRNA.
DR PIR; T05473; T05473.
DR RefSeq; NP_001320028.1; NM_001341522.1. [Q940N9-2]
DR RefSeq; NP_567640.1; NM_118312.2. [Q940N9-1]
DR RefSeq; NP_974587.1; NM_202858.2. [Q940N9-2]
DR RefSeq; NP_974588.1; NM_202859.2. [Q940N9-1]
DR AlphaFoldDB; Q940N9; -.
DR SMR; Q940N9; -.
DR IntAct; Q940N9; 1.
DR STRING; 3702.AT4G21910.4; -.
DR PRIDE; Q940N9; -.
DR ProteomicsDB; 222187; -. [Q940N9-1]
DR EnsemblPlants; AT4G21910.1; AT4G21910.1; AT4G21910. [Q940N9-1]
DR EnsemblPlants; AT4G21910.2; AT4G21910.2; AT4G21910. [Q940N9-2]
DR EnsemblPlants; AT4G21910.3; AT4G21910.3; AT4G21910. [Q940N9-1]
DR EnsemblPlants; AT4G21910.4; AT4G21910.4; AT4G21910. [Q940N9-2]
DR GeneID; 828280; -.
DR Gramene; AT4G21910.1; AT4G21910.1; AT4G21910. [Q940N9-1]
DR Gramene; AT4G21910.2; AT4G21910.2; AT4G21910. [Q940N9-2]
DR Gramene; AT4G21910.3; AT4G21910.3; AT4G21910. [Q940N9-1]
DR Gramene; AT4G21910.4; AT4G21910.4; AT4G21910. [Q940N9-2]
DR KEGG; ath:AT4G21910; -.
DR Araport; AT4G21910; -.
DR TAIR; locus:2141672; AT4G21910.
DR eggNOG; KOG1347; Eukaryota.
DR OMA; YVPLACH; -.
DR OrthoDB; 743037at2759; -.
DR PhylomeDB; Q940N9; -.
DR PRO; PR:Q940N9; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q940N9; baseline and differential.
DR Genevisible; Q940N9; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR Pfam; PF01554; MatE; 2.
DR TIGRFAMs; TIGR00797; matE; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..507
FT /note="Protein DETOXIFICATION 39"
FT /id="PRO_0000434080"
FT TRANSMEM 58..78
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..307
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 318..338
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 359..379
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 403..423
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 433..453
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 459..479
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..103
FT /note="MDVSNETVERTDLRTPLVDPADTEVKPLPEVGLESVLTESSLSYRRRVYLGA
FT CIELKVLFRLALPAILIYLVNSGMGISARVFAGHVGSQELAAASIGNSCFN -> MEVP
FT SETTNLADLRRPLVVPVVSERKPPADVGLGLESVLTERSLPYRRRVYLGACIEMKLLFR
FT LALPAILVYLVNSGMGISARIFAGHLGKNELAAASIGNSCFS (in isoform 2)"
FT /id="VSP_057897"
FT CONFLICT 53
FT /note="C -> G (in Ref. 5; AAM62936)"
FT /evidence="ECO:0000305"
FT CONFLICT 264
FT /note="T -> A (in Ref. 4; BAH19969)"
FT /evidence="ECO:0000305"
FT CONFLICT 325
FT /note="A -> T (in Ref. 4; BAH19969)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 507 AA; 55690 MW; 2546CA63C82612C0 CRC64;
MDVSNETVER TDLRTPLVDP ADTEVKPLPE VGLESVLTES SLSYRRRVYL GACIELKVLF
RLALPAILIY LVNSGMGISA RVFAGHVGSQ ELAAASIGNS CFNLVYGLML GMGSAVETLC
GQAYGAHRYE MLGIYLQRAT IVLALVGLPM TLLYTFSYPI LILLGEPKTV SYMGSKYIAG
LIPQIFAYAV NFTAQKFLQA QSVVAPSAFI SAAALILQIL LTWITVYVMD MGFMGIAYVL
TISWWVIVGS QCFYIAVSPK FRHTWTGLSW RSLQGLWSFF KLSAGSAVMI CLEMWYSQIL
VLLAGLLENP ARSLDSLSIC MSISALSFMV SVGFNAAVSV RTSNELGAGN PKSAWFSTWT
ATFVSFVISV TEALAVIWFR DYVSYIFTED ADVAKAVSDL CPFLAITIIL NGIQPVLSGV
AVGCGWQTYV AYVNVGCYYV VGIPVGCILG FTFDFQAKGI WTGMIGGTLM QTLILLYVTY
RTDWDKEVEK ARKRLDLWDD KKEPLQN
