DTX3_ARATH
ID DTX3_ARATH Reviewed; 476 AA.
AC Q9SIA4;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Protein DETOXIFICATION 3 {ECO:0000303|PubMed:11739388};
DE Short=AtDTX3 {ECO:0000303|PubMed:11739388};
DE AltName: Full=Multidrug and toxic compound extrusion protein 3 {ECO:0000305};
DE Short=MATE protein 3 {ECO:0000305};
GN Name=DTX3 {ECO:0000303|PubMed:11739388};
GN OrderedLocusNames=At2g04050 {ECO:0000312|Araport:AT2G04050};
GN ORFNames=F3L12.12 {ECO:0000312|EMBL:AAD28686.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11739388; DOI=10.1074/jbc.m108777200;
RA Li L., He Z., Pandey G.K., Tsuchiya T., Luan S.;
RT "Functional cloning and characterization of a plant efflux carrier for
RT multidrug and heavy metal detoxification.";
RL J. Biol. Chem. 277:5360-5368(2002).
RN [4]
RP GENE FAMILY.
RX PubMed=12603313; DOI=10.1046/j.1432-1033.2003.03418.x;
RA Hvorup R.N., Winnen B., Chang A.B., Jiang Y., Zhou X.F., Saier M.H. Jr.;
RT "The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter
RT superfamily.";
RL Eur. J. Biochem. 270:799-813(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC007178; AAD28686.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC05792.1; -; Genomic_DNA.
DR PIR; B84454; B84454.
DR RefSeq; NP_178492.1; NM_126444.2.
DR AlphaFoldDB; Q9SIA4; -.
DR SMR; Q9SIA4; -.
DR BioGRID; 340; 9.
DR IntAct; Q9SIA4; 7.
DR STRING; 3702.AT2G04050.1; -.
DR PaxDb; Q9SIA4; -.
DR PRIDE; Q9SIA4; -.
DR EnsemblPlants; AT2G04050.1; AT2G04050.1; AT2G04050.
DR GeneID; 814939; -.
DR Gramene; AT2G04050.1; AT2G04050.1; AT2G04050.
DR KEGG; ath:AT2G04050; -.
DR Araport; AT2G04050; -.
DR TAIR; locus:2050180; AT2G04050.
DR eggNOG; KOG1347; Eukaryota.
DR HOGENOM; CLU_012893_1_0_1; -.
DR InParanoid; Q9SIA4; -.
DR OMA; VSNIPIC; -.
DR OrthoDB; 743037at2759; -.
DR PhylomeDB; Q9SIA4; -.
DR PRO; PR:Q9SIA4; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9SIA4; baseline and differential.
DR Genevisible; Q9SIA4; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR Pfam; PF01554; MatE; 2.
DR TIGRFAMs; TIGR00797; matE; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..476
FT /note="Protein DETOXIFICATION 3"
FT /id="PRO_0000405320"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 208..228
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..280
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 289..309
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 331..351
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 370..390
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 402..422
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 433..453
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 476 AA; 51468 MW; 03A1E1AE2CCFED18 CRC64;
MEEPFLLQDE HLVPCKDTWK SGQVTVELKK VSSLAAPMAA VTIAQYLLPV ISVMVAGHNG
ELQLSGVALA TSFTNVSGFS ILFGLAGALE TLCGQAYGAK QYEKIGTYTY SATASNIPIC
VLISVLWIYI EKLLISLGQD PDISRVAGSY ALWLIPALFA HAFFIPLTRF LLAQGLVLPL
LYCTLTTLLF HIPVCWAFVY AFGLGSNGAA MAISVSFWFY VVILSCYVRY SSSCDKTRVF
VSSDFVSCIK QFFHFGVPSA AMVCLEWWLF ELLILCSGLL PNPKLETSVL SICLTTASLH
YVIPGGVAAA VSTRVSNKLG AGIPQVARVS VLAGLCLWLV ESAFFSTLLF TCRNIIGYAF
SNSKEVVDYV ANLTPLLCLS FILDGFTAVL NGVARGSGWQ HIGALNNVVA YYLVGAPVGV
YLAFNRELNG KGLWCGVVVG SAVQAIILAF VTASINWKEQ AEKARKRMVS SENRLA
