DTX40_ARATH
ID DTX40_ARATH Reviewed; 506 AA.
AC Q9LVD9; Q8LPI3;
DT 14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Protein DETOXIFICATION 40 {ECO:0000303|PubMed:11739388};
DE Short=AtDTX40 {ECO:0000303|PubMed:11739388};
DE AltName: Full=Multidrug and toxic compound extrusion protein 40 {ECO:0000305};
DE Short=MATE protein 40 {ECO:0000305};
GN Name=DTX40 {ECO:0000303|PubMed:11739388};
GN OrderedLocusNames=At3g21690 {ECO:0000312|Araport:AT3G21690};
GN ORFNames=MIL23.25 {ECO:0000312|EMBL:BAB02363.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11739388; DOI=10.1074/jbc.m108777200;
RA Li L., He Z., Pandey G.K., Tsuchiya T., Luan S.;
RT "Functional cloning and characterization of a plant efflux carrier for
RT multidrug and heavy metal detoxification.";
RL J. Biol. Chem. 277:5360-5368(2002).
RN [6]
RP GENE FAMILY.
RX PubMed=12603313; DOI=10.1046/j.1432-1033.2003.03418.x;
RA Hvorup R.N., Winnen B., Chang A.B., Jiang Y., Zhou X.F., Saier M.H. Jr.;
RT "The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter
RT superfamily.";
RL Eur. J. Biochem. 270:799-813(2003).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION [LARGE SCALE
RP ANALYSIS].
RX PubMed=17151019; DOI=10.1074/mcp.m600250-mcp200;
RA Jaquinod M., Villiers F., Kieffer-Jaquinod S., Hugouvieux V., Bruley C.,
RA Garin J., Bourguignon J.;
RT "A proteomics dissection of Arabidopsis thaliana vacuoles isolated from
RT cell culture.";
RL Mol. Cell. Proteomics 6:394-412(2007).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RX PubMed=23903016; DOI=10.1093/pcp/pct107;
RA Yoshida K., Ohnishi M., Fukao Y., Okazaki Y., Fujiwara M., Song C.,
RA Nakanishi Y., Saito K., Shimmen T., Suzaki T., Hayashi F., Fukaki H.,
RA Maeshima M., Mimura T.;
RT "Studies on vacuolar membrane microdomains isolated from Arabidopsis
RT suspension-cultured cells: local distribution of vacuolar membrane
RT proteins.";
RL Plant Cell Physiol. 54:1571-1584(2013).
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000269|PubMed:17151019,
CC ECO:0000269|PubMed:23903016}; Multi-pass membrane protein {ECO:0000255,
CC ECO:0000269|PubMed:23903016}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000305}.
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DR EMBL; AB019232; BAB02363.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE76538.1; -; Genomic_DNA.
DR EMBL; AY099744; AAM20595.1; -; mRNA.
DR EMBL; BT015408; AAU05531.1; -; mRNA.
DR RefSeq; NP_188806.1; NM_113064.5.
DR AlphaFoldDB; Q9LVD9; -.
DR SMR; Q9LVD9; -.
DR IntAct; Q9LVD9; 25.
DR STRING; 3702.AT3G21690.1; -.
DR PaxDb; Q9LVD9; -.
DR PRIDE; Q9LVD9; -.
DR ProteomicsDB; 221825; -.
DR EnsemblPlants; AT3G21690.1; AT3G21690.1; AT3G21690.
DR GeneID; 821723; -.
DR Gramene; AT3G21690.1; AT3G21690.1; AT3G21690.
DR KEGG; ath:AT3G21690; -.
DR Araport; AT3G21690; -.
DR TAIR; locus:2089955; AT3G21690.
DR eggNOG; KOG1347; Eukaryota.
DR HOGENOM; CLU_012893_1_4_1; -.
DR InParanoid; Q9LVD9; -.
DR OMA; LAWITFR; -.
DR OrthoDB; 743037at2759; -.
DR PhylomeDB; Q9LVD9; -.
DR PRO; PR:Q9LVD9; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LVD9; baseline and differential.
DR Genevisible; Q9LVD9; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0000325; C:plant-type vacuole; HDA:TAIR.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005773; C:vacuole; IDA:UniProtKB.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR Pfam; PF01554; MatE; 2.
DR TIGRFAMs; TIGR00797; matE; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport; Vacuole.
FT CHAIN 1..506
FT /note="Protein DETOXIFICATION 40"
FT /id="PRO_0000434081"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..247
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..305
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 316..336
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 356..376
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 401..421
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 433..453
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 458..478
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 314
FT /note="S -> P (in Ref. 3; AAM20595)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 506 AA; 54952 MW; FD9FF939CAA07720 CRC64;
MDSSPNDGVH QPLLHPQPSP SPPESTNGEL ETVLSDVETP LFLRLRKATI IESKLLFNLA
APAVIVYMIN YLMSMSTQIF SGHLGNLELA AASLGNTGIQ VFAYGLMLGM GSAVETLCGQ
AYGGRKYEML GVYLQRSTVL LTLTGLLLTL IYVFSEPILL FLGESPAIAS AASLFVYGLI
PQIFAYAANF PIQKFLQSQS IVAPSAYIST ATLFVHLLLS WLAVYKLGMG LLGASLVLSL
SWWIIVVAQF VYIVTSERCR ETWRGFSVQA FSGLWSFFKL SAASAVMLCL ETWYFQILVL
LAGLLENPEL ALDSLSICMT ISGWVFMISV GFNAAISVRV SNELGAGNPK SAAFSVIIVN
IYSLITCVIL AIVILACRDV LSYAFTEGKE VSDAVSDLCP LLAVTLVLNG IQPVLSGVAV
GCGWQTFVAK VNVGCYYIIG IPLGALFGFY FNFGAKGIWT GMIGGTVIQT FILAWVTFRT
DWTKEVEEAS KRLDKWSNKK QEVVPE
