DTX4_ARATH
ID DTX4_ARATH Reviewed; 476 AA.
AC Q9SIA3;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 03-MAY-2011, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Protein DETOXIFICATION 4 {ECO:0000303|PubMed:11739388};
DE Short=AtDTX4 {ECO:0000303|PubMed:11739388};
DE AltName: Full=Multidrug and toxic compound extrusion protein 4 {ECO:0000305};
DE Short=MATE protein 4 {ECO:0000305};
GN Name=DTX4 {ECO:0000303|PubMed:11739388};
GN OrderedLocusNames=At2g04070 {ECO:0000312|Araport:AT2G04070};
GN ORFNames=F3L12.10 {ECO:0000312|EMBL:AAD28685.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11739388; DOI=10.1074/jbc.m108777200;
RA Li L., He Z., Pandey G.K., Tsuchiya T., Luan S.;
RT "Functional cloning and characterization of a plant efflux carrier for
RT multidrug and heavy metal detoxification.";
RL J. Biol. Chem. 277:5360-5368(2002).
RN [4]
RP GENE FAMILY.
RX PubMed=12603313; DOI=10.1046/j.1432-1033.2003.03418.x;
RA Hvorup R.N., Winnen B., Chang A.B., Jiang Y., Zhou X.F., Saier M.H. Jr.;
RT "The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter
RT superfamily.";
RL Eur. J. Biochem. 270:799-813(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000305}.
CC -!- CAUTION: Mistakenly referred to as AT2G04040 in PubMed:11739388.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD28685.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC007178; AAD28685.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC05796.1; -; Genomic_DNA.
DR PIR; C84454; C84454.
DR RefSeq; NP_178496.2; NM_126448.3.
DR AlphaFoldDB; Q9SIA3; -.
DR SMR; Q9SIA3; -.
DR STRING; 3702.AT2G04070.1; -.
DR TCDB; 2.A.66.1.56; the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily.
DR PaxDb; Q9SIA3; -.
DR PRIDE; Q9SIA3; -.
DR EnsemblPlants; AT2G04070.1; AT2G04070.1; AT2G04070.
DR GeneID; 814943; -.
DR Gramene; AT2G04070.1; AT2G04070.1; AT2G04070.
DR KEGG; ath:AT2G04070; -.
DR Araport; AT2G04070; -.
DR TAIR; locus:2050225; AT2G04070.
DR eggNOG; KOG1347; Eukaryota.
DR HOGENOM; CLU_012893_1_4_1; -.
DR InParanoid; Q9SIA3; -.
DR OMA; VISSMNW; -.
DR OrthoDB; 743037at2759; -.
DR PRO; PR:Q9SIA3; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9SIA3; baseline and differential.
DR Genevisible; Q9SIA3; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR Pfam; PF01554; MatE; 2.
DR TIGRFAMs; TIGR00797; matE; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..476
FT /note="Protein DETOXIFICATION 4"
FT /id="PRO_0000405321"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 208..228
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..280
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 289..309
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 332..352
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 370..390
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 408..428
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 433..453
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 476 AA; 51489 MW; DF156E1F0C642502 CRC64;
MEEPFLPQDE QIVPCKATWK SGQLNVELKK VSRLAVPMAT VTIAQYLLPV ISVMVAGHNG
ELQLSGVALA TSFTNVSGFS IMFGLVGSLE TLSGQAYGAK QYEKMGTYTY SAISSNIPIC
VLISILWIYM EKLLISLGQD PDISRVAGSY ALRLIPTLFA HAIVLPLTRF LLAQGLVLPL
LYFALTTLLF HIAVCWTLVS ALGLGSNGAA LAISVSFWFF AMTLSCYVRF SSSCEKTRRF
VSQDFLSSVK QFFRYGVPSA AMLCLEWWLF ELLILCSGLL QNPKLETSVL SICLTTATLH
YVIPVGVAAA VSTRVSNKLG AGIPQVARVS VLAGLCLWLV ESSFFSILLF AFRNIIGYAF
SNSKEVVDYV ADLSPLLCLS FVLDGFTAVL NGVARGCGWQ HIGALNNVVA YYLVGAPVGI
YLAFSCELNG KGLWCGVVVG SAVQAIILAI VTASMNWKEQ AKKARKRLIS SENGLA
