DTX52_ARATH
ID DTX52_ARATH Reviewed; 508 AA.
AC Q4PSF4;
DT 14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Protein DETOXIFICATION 52 {ECO:0000303|PubMed:11739388};
DE Short=AtDTX52 {ECO:0000303|PubMed:11739388};
DE AltName: Full=Multidrug and toxic compound extrusion protein 52 {ECO:0000305};
DE Short=MATE protein 52 {ECO:0000305};
DE AltName: Full=Protein ABNORMAL SHOOT 3-like 2 {ECO:0000303|PubMed:26160579};
GN Name=DTX52 {ECO:0000303|PubMed:11739388};
GN Synonyms=ABS3L2 {ECO:0000303|PubMed:26160579};
GN OrderedLocusNames=At5g19700 {ECO:0000312|Araport:AT5G19700};
GN ORFNames=T29J13.120 {ECO:0000312|EMBL:AF296838};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11739388; DOI=10.1074/jbc.m108777200;
RA Li L., He Z., Pandey G.K., Tsuchiya T., Luan S.;
RT "Functional cloning and characterization of a plant efflux carrier for
RT multidrug and heavy metal detoxification.";
RL J. Biol. Chem. 277:5360-5368(2002).
RN [5]
RP GENE FAMILY.
RX PubMed=12603313; DOI=10.1046/j.1432-1033.2003.03418.x;
RA Hvorup R.N., Winnen B., Chang A.B., Jiang Y., Zhou X.F., Saier M.H. Jr.;
RT "The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter
RT superfamily.";
RL Eur. J. Biochem. 270:799-813(2003).
RN [6]
RP TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND FUNCTION.
RX PubMed=26160579; DOI=10.1093/jxb/erv344;
RA Wang R., Liu X., Liang S., Ge Q., Li Y., Shao J., Qi Y., An L., Yu F.;
RT "A subgroup of MATE transporter genes regulates hypocotyl cell elongation
RT in Arabidopsis.";
RL J. Exp. Bot. 66:6327-6343(2015).
CC -!- FUNCTION: May act as a negative regulator of hypocotyl cell elongation
CC in the light. {ECO:0000269|PubMed:26160579}.
CC -!- SUBCELLULAR LOCATION: Late endosome membrane
CC {ECO:0000269|PubMed:26160579}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:26160579}.
CC -!- TISSUE SPECIFICITY: Detected in the part of the veins in cotyledons of
CC 6-day-old seedlings and the basal parts of the petioles in older
CC plants. Highly expressed in the vascular tissues of hypocotyl in dark-
CC grown seedlings. {ECO:0000269|PubMed:26160579}.
CC -!- MISCELLANEOUS: Overexpression of DTX52 alters shoot developmental
CC programs leading to a loss of apical dominance phenotype.
CC {ECO:0000269|PubMed:26160579}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF296838; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002688; AED92739.1; -; Genomic_DNA.
DR EMBL; DQ056682; AAY78828.1; -; mRNA.
DR RefSeq; NP_197471.1; NM_121975.2.
DR AlphaFoldDB; Q4PSF4; -.
DR SMR; Q4PSF4; -.
DR IntAct; Q4PSF4; 11.
DR STRING; 3702.AT5G19700.1; -.
DR PaxDb; Q4PSF4; -.
DR PRIDE; Q4PSF4; -.
DR EnsemblPlants; AT5G19700.1; AT5G19700.1; AT5G19700.
DR GeneID; 832090; -.
DR Gramene; AT5G19700.1; AT5G19700.1; AT5G19700.
DR KEGG; ath:AT5G19700; -.
DR Araport; AT5G19700; -.
DR TAIR; locus:2183169; AT5G19700.
DR eggNOG; KOG1347; Eukaryota.
DR HOGENOM; CLU_012893_1_0_1; -.
DR InParanoid; Q4PSF4; -.
DR OMA; DVWGMIF; -.
DR OrthoDB; 743037at2759; -.
DR PhylomeDB; Q4PSF4; -.
DR PRO; PR:Q4PSF4; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q4PSF4; baseline and differential.
DR Genevisible; Q4PSF4; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005770; C:late endosome; IDA:UniProtKB.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0055072; P:iron ion homeostasis; IMP:TAIR.
DR GO; GO:0010150; P:leaf senescence; IMP:TAIR.
DR GO; GO:0010015; P:root morphogenesis; IMP:UniProtKB.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR Pfam; PF01554; MatE; 2.
DR TIGRFAMs; TIGR00797; matE; 1.
PE 2: Evidence at transcript level;
KW Endosome; Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..508
FT /note="Protein DETOXIFICATION 52"
FT /id="PRO_0000434086"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TRANSMEM 189..209
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..242
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 341..361
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 368..388
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 415..437
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 441..463
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 508 AA; 54327 MW; 806BDD4AD6C1DCC4 CRC64;
METPNIISHT NLLSKIDLEK QNPAPIFPTI TELKSEARSL FSLAFPTILA ALILYARSAI
SMLFLGHIGE LELAGGSLAI AFANITGYSV LAGLALGMDP LCSQAFGAGR PKLLSLTLQR
TVLFLLTSSV VIVALWLNLG KIMIYLHQDP SISSLAQTYI LCSIPDLLTN SFLHPLRIYL
RAQGITSPLT LATLAGTIFH IPMNFFLVSY LGWGFMGVSM AAAASNLLVV IFLVAHVWIA
GLHQPTWTRP SSECFKDWGP VVTLAIPSCI GVCLEWWWYE IMTVLCGLLI DPSTPVASMG
ILIQTTSLLY IFPSSLGLAV STRVGNELGS NRPNKARLSA IVAVSFAGVM GLTASAFAWG
VSDVWGWIFT NDVAIIKLTA AALPILGLCE LGNCPQTVGC GVVRGTARPS MAANINLGAF
YLVGTPVAVG LTFWAAYGFC GLWVGLLAAQ ICCAAMMLYV VATTDWEKEA IRARKLTCTE
GVDVVITTTQ TNGDLSEPLI YVVTVATD
