DTX53_ARATH
ID DTX53_ARATH Reviewed; 486 AA.
AC Q9ZVH5;
DT 14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Protein DETOXIFICATION 53 {ECO:0000303|PubMed:11739388};
DE Short=AtDTX53 {ECO:0000303|PubMed:11739388};
DE AltName: Full=Multidrug and toxic compound extrusion protein 53 {ECO:0000305};
DE Short=MATE protein 53 {ECO:0000305};
GN Name=DTX53 {ECO:0000303|PubMed:11739388};
GN OrderedLocusNames=At2g38510 {ECO:0000312|Araport:AT2G38510};
GN ORFNames=T6A23.29 {ECO:0000312|EMBL:AAC67367.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11739388; DOI=10.1074/jbc.m108777200;
RA Li L., He Z., Pandey G.K., Tsuchiya T., Luan S.;
RT "Functional cloning and characterization of a plant efflux carrier for
RT multidrug and heavy metal detoxification.";
RL J. Biol. Chem. 277:5360-5368(2002).
RN [5]
RP GENE FAMILY.
RX PubMed=12603313; DOI=10.1046/j.1432-1033.2003.03418.x;
RA Hvorup R.N., Winnen B., Chang A.B., Jiang Y., Zhou X.F., Saier M.H. Jr.;
RT "The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter
RT superfamily.";
RL Eur. J. Biochem. 270:799-813(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000305}.
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DR EMBL; AC005499; AAC67367.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC09545.1; -; Genomic_DNA.
DR EMBL; DQ056572; AAY78722.1; -; mRNA.
DR PIR; H84805; H84805.
DR RefSeq; NP_181385.1; NM_129408.2.
DR AlphaFoldDB; Q9ZVH5; -.
DR SMR; Q9ZVH5; -.
DR IntAct; Q9ZVH5; 34.
DR STRING; 3702.AT2G38510.1; -.
DR PaxDb; Q9ZVH5; -.
DR PRIDE; Q9ZVH5; -.
DR EnsemblPlants; AT2G38510.1; AT2G38510.1; AT2G38510.
DR GeneID; 818433; -.
DR Gramene; AT2G38510.1; AT2G38510.1; AT2G38510.
DR KEGG; ath:AT2G38510; -.
DR Araport; AT2G38510; -.
DR TAIR; locus:2064138; AT2G38510.
DR eggNOG; KOG1347; Eukaryota.
DR HOGENOM; CLU_012893_1_0_1; -.
DR InParanoid; Q9ZVH5; -.
DR OMA; VTGYSVM; -.
DR OrthoDB; 743037at2759; -.
DR PhylomeDB; Q9ZVH5; -.
DR PRO; PR:Q9ZVH5; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9ZVH5; baseline and differential.
DR Genevisible; Q9ZVH5; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR Pfam; PF01554; MatE; 2.
DR TIGRFAMs; TIGR00797; matE; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..486
FT /note="Protein DETOXIFICATION 53"
FT /id="PRO_0000434087"
FT TRANSMEM 15..35
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 267..287
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 312..332
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 346..366
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 386..406
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 413..433
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 448..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..470
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 486 AA; 52534 MW; 335E569DC56532C0 CRC64;
MQVGEEMASL TKIACPIVMT SLLIFSRSII SMWFLSHLGK VELAGGALAM GFGNITGVSV
LKGLSVGMDP ICGQAFGAKR WTVLSHTFQK MFCLLIVVSV PIAVTWLNIE PIFLRLGQDP
DITKVAKTYM LFFVPELLAQ AMLHPLRTFL RTQGLTSPLT ISAIVSILLH PLFNYVFVVR
MRLGVKGVAI AMAFNTMNID VGLLVYTCFS DSLIKPWEGL ALRSLFRGWW PLLSLAAPSA
ISVCLEYWWY EIMLFLCGLL GNPKASVAAM GILIQTTGIL YVVPFAISSA IATRVGHALG
GGQPTRAQCT TVIGLILAVA YGLAAAVFVT ALRSVWGKMF TDEPEILGLI SAALPILGLC
EIGNSPQTAA CGVLTGTARP KDGARVNLCA FYIVGLPVAV TTTFGFKVGF RGLWFGLLSA
QMTCLVMMLY TLIRTDWSHQ VKRAEELTSA AADKSHSEDE TVHAEVQDDD DVSSNDLEIG
LLQNTN
