DTX55_ARATH
ID DTX55_ARATH Reviewed; 502 AA.
AC Q9FH21;
DT 14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Protein DETOXIFICATION 55 {ECO:0000303|PubMed:11739388};
DE Short=AtDTX55 {ECO:0000303|PubMed:11739388};
DE AltName: Full=Multidrug and toxic compound extrusion protein 55 {ECO:0000305};
DE Short=MATE protein 55 {ECO:0000305};
DE AltName: Full=Protein NOVEL ION CARRIER 3 {ECO:0000303|Ref.1};
DE Short=Protein NIC3 {ECO:0000303|Ref.1};
GN Name=DTX55 {ECO:0000303|PubMed:11739388};
GN Synonyms=NIC3 {ECO:0000312|EMBL:AAO85438.1};
GN OrderedLocusNames=At5g49130 {ECO:0000312|Araport:AT5G49130};
GN ORFNames=K20J1.11 {ECO:0000312|EMBL:BAB10095.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Pellengahr K., Poree F., Dolniak B., Kursawe M., Mueller-Roeber B.;
RT "Four membrane transport proteins of the Arabidopsis MATE-family influence
RT the Na+- and Li+ tolerance in yeast.";
RL Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:31-63(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11739388; DOI=10.1074/jbc.m108777200;
RA Li L., He Z., Pandey G.K., Tsuchiya T., Luan S.;
RT "Functional cloning and characterization of a plant efflux carrier for
RT multidrug and heavy metal detoxification.";
RL J. Biol. Chem. 277:5360-5368(2002).
RN [5]
RP GENE FAMILY.
RX PubMed=12603313; DOI=10.1046/j.1432-1033.2003.03418.x;
RA Hvorup R.N., Winnen B., Chang A.B., Jiang Y., Zhou X.F., Saier M.H. Jr.;
RT "The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter
RT superfamily.";
RL Eur. J. Biochem. 270:799-813(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000305}.
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DR EMBL; AF488694; AAO85438.1; -; mRNA.
DR EMBL; AB023028; BAB10095.1; -; Genomic_DNA.
DR EMBL; CP002688; AED95774.1; -; Genomic_DNA.
DR RefSeq; NP_199724.1; NM_124290.3.
DR AlphaFoldDB; Q9FH21; -.
DR SMR; Q9FH21; -.
DR IntAct; Q9FH21; 40.
DR STRING; 3702.AT5G49130.1; -.
DR PaxDb; Q9FH21; -.
DR PRIDE; Q9FH21; -.
DR ProteomicsDB; 221829; -.
DR EnsemblPlants; AT5G49130.1; AT5G49130.1; AT5G49130.
DR GeneID; 834972; -.
DR Gramene; AT5G49130.1; AT5G49130.1; AT5G49130.
DR KEGG; ath:AT5G49130; -.
DR Araport; AT5G49130; -.
DR TAIR; locus:2155179; AT5G49130.
DR eggNOG; KOG1347; Eukaryota.
DR HOGENOM; CLU_012893_1_0_1; -.
DR InParanoid; Q9FH21; -.
DR OMA; RYAIPDL; -.
DR OrthoDB; 743037at2759; -.
DR PhylomeDB; Q9FH21; -.
DR PRO; PR:Q9FH21; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FH21; differential.
DR Genevisible; Q9FH21; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR Pfam; PF01554; MatE; 2.
DR TIGRFAMs; TIGR00797; matE; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..502
FT /note="Protein DETOXIFICATION 55"
FT /id="PRO_0000434089"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 261..283
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 298..318
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 344..364
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 378..398
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 419..439
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 447..467
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 502 AA; 54139 MW; 0214F61CEBBA9961 CRC64;
MVVEEDSRLI NLQHKYNPTM PEVVEELKRI WDISFPVAAM SILNYLKNMT SVVCMGRLGS
LELAGGALAI GFTNITGYSV LSGLATGMEP LCGQAIGSKN PSLASLTLKR TIFLLLLASL
PISLLWLNLA PLMLMLRQQH DITRVASLYC SFSLPDLLAN SFLHPLRIYL RCKGTTWPLM
WCTLVSVLLH LPITAFFTFY ISLGVPGVAV SSFLTNFISL SLLLCYIYLE NNNNDKTTSK
SLCLDTPLML YGSRDSGEND VWSTLVKFAV PSCIAVCLEW WWYEFMTVLA GYLPEPKVAL
AAAAIVIQTT SLMYTIPTAL SAAVSTRVSN ELGAGRPEKA KTAATVAVGA AVAVSVFGLV
GTTVGREAWG KVFTADKVVL ELTAAVIPVI GACELANCPQ TISCGILRGS ARPGIGAKIN
FYAFYVVGAP VAVVLAFVWG LGFMGLCYGL LGAQLACAIS ILTVVYNTDW NKESLKAHDL
VGKNVISPNV DQIIVKCEEG LH
