DTX5_ARATH
ID DTX5_ARATH Reviewed; 477 AA.
AC Q9SIA1;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 08-MAR-2011, sequence version 2.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Protein DETOXIFICATION 5 {ECO:0000303|PubMed:11739388};
DE Short=AtDTX5 {ECO:0000303|PubMed:11739388};
DE AltName: Full=Multidrug and toxic compound extrusion protein 5 {ECO:0000305};
DE Short=MATE protein 5 {ECO:0000305};
GN Name=DTX5 {ECO:0000303|PubMed:11739388};
GN OrderedLocusNames=At2g04090 {ECO:0000312|Araport:AT2G04090};
GN ORFNames=F3L12.8 {ECO:0000312|EMBL:AEC05798.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11739388; DOI=10.1074/jbc.m108777200;
RA Li L., He Z., Pandey G.K., Tsuchiya T., Luan S.;
RT "Functional cloning and characterization of a plant efflux carrier for
RT multidrug and heavy metal detoxification.";
RL J. Biol. Chem. 277:5360-5368(2002).
RN [4]
RP GENE FAMILY.
RX PubMed=12603313; DOI=10.1046/j.1432-1033.2003.03418.x;
RA Hvorup R.N., Winnen B., Chang A.B., Jiang Y., Zhou X.F., Saier M.H. Jr.;
RT "The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter
RT superfamily.";
RL Eur. J. Biochem. 270:799-813(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD28683.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC007178; AAD28683.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC05798.1; -; Genomic_DNA.
DR PIR; E84454; E84454.
DR RefSeq; NP_178498.2; NM_126450.3.
DR AlphaFoldDB; Q9SIA1; -.
DR SMR; Q9SIA1; -.
DR STRING; 3702.AT2G04090.1; -.
DR PaxDb; Q9SIA1; -.
DR PRIDE; Q9SIA1; -.
DR ProteomicsDB; 224287; -.
DR EnsemblPlants; AT2G04090.1; AT2G04090.1; AT2G04090.
DR GeneID; 814945; -.
DR Gramene; AT2G04090.1; AT2G04090.1; AT2G04090.
DR KEGG; ath:AT2G04090; -.
DR Araport; AT2G04090; -.
DR TAIR; locus:2050175; AT2G04090.
DR eggNOG; KOG1347; Eukaryota.
DR HOGENOM; CLU_012893_1_0_1; -.
DR InParanoid; Q9SIA1; -.
DR OMA; NIGAWAN; -.
DR OrthoDB; 743037at2759; -.
DR PhylomeDB; Q9SIA1; -.
DR PRO; PR:Q9SIA1; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9SIA1; baseline and differential.
DR Genevisible; Q9SIA1; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR Pfam; PF01554; MatE; 2.
DR TIGRFAMs; TIGR00797; matE; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..477
FT /note="Protein DETOXIFICATION 5"
FT /id="PRO_0000405323"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 333..353
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 376..396
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 411..431
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 436..456
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 477 AA; 51306 MW; E832C46FB7EBCA07 CRC64;
MEDPLLLGDD QLITRNLKST PTWWMNFTAE LKNVSSMAAP MATVTVSQYL LPVISVMVAG
HCGELQLSGV TLATAFANVS GFGIMYGLVG ALETLCGQAY GAKQYTKIGT YTFSAIVSNV
PIVVLISILW FYMDKLFVSL GQDPDISKVA GSYAVCLIPA LLAQAVQQPL TRFLQTQGLV
LPLLYCAITT LLFHIPVCLI LVYAFGLGSN GAALAIGLSY WFNVLILALY VRFSSACEKT
RGFVSDDFVL SVKQFFQYGI PSAAMTTIEW SLFELLILSS GLLPNPKLET SVLSICLTTS
SLHCVIPMGI GAAGSTRISN ELGAGNPEVA RLAVFAGIFL WFLEATICST LLFTCKNIFG
YAFSNSKEVV DYVTELSSLL CLSFMVDGFS SVLDGVARGS GWQNIGAWAN VVAYYLLGAP
VGFFLGFWGH MNGKGLWIGV IVGSTAQGII LAIVTACLSW EEQAAKARER IVGRTLE
