DTX6_ARATH
ID DTX6_ARATH Reviewed; 483 AA.
AC Q8RWF5; Q9SIA0;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 25-MAY-2022, entry version 107.
DE RecName: Full=Protein DETOXIFICATION 6 {ECO:0000303|PubMed:11739388};
DE Short=AtDTX6 {ECO:0000303|PubMed:11739388};
DE AltName: Full=Multidrug and toxic compound extrusion protein 6 {ECO:0000305};
DE Short=MATE protein 6 {ECO:0000305};
GN Name=DTX6 {ECO:0000303|PubMed:11739388};
GN OrderedLocusNames=At2g04100 {ECO:0000312|Araport:AT2G04100};
GN ORFNames=F3L12.7 {ECO:0000312|EMBL:AAD28682.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11739388; DOI=10.1074/jbc.m108777200;
RA Li L., He Z., Pandey G.K., Tsuchiya T., Luan S.;
RT "Functional cloning and characterization of a plant efflux carrier for
RT multidrug and heavy metal detoxification.";
RL J. Biol. Chem. 277:5360-5368(2002).
RN [5]
RP GENE FAMILY.
RX PubMed=12603313; DOI=10.1046/j.1432-1033.2003.03418.x;
RA Hvorup R.N., Winnen B., Chang A.B., Jiang Y., Zhou X.F., Saier M.H. Jr.;
RT "The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter
RT superfamily.";
RL Eur. J. Biochem. 270:799-813(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD28682.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC007178; AAD28682.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC05799.1; -; Genomic_DNA.
DR EMBL; AY093126; AAM13125.1; -; mRNA.
DR EMBL; BT006624; AAP31968.1; -; mRNA.
DR PIR; F84454; F84454.
DR RefSeq; NP_178499.2; NM_126451.5.
DR AlphaFoldDB; Q8RWF5; -.
DR SMR; Q8RWF5; -.
DR BioGRID; 347; 5.
DR IntAct; Q8RWF5; 1.
DR STRING; 3702.AT2G04100.1; -.
DR PaxDb; Q8RWF5; -.
DR EnsemblPlants; AT2G04100.1; AT2G04100.1; AT2G04100.
DR GeneID; 814946; -.
DR Gramene; AT2G04100.1; AT2G04100.1; AT2G04100.
DR KEGG; ath:AT2G04100; -.
DR Araport; AT2G04100; -.
DR TAIR; locus:2050230; AT2G04100.
DR eggNOG; KOG1347; Eukaryota.
DR HOGENOM; CLU_012893_1_0_1; -.
DR InParanoid; Q8RWF5; -.
DR OrthoDB; 743037at2759; -.
DR PhylomeDB; Q8RWF5; -.
DR PRO; PR:Q8RWF5; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q8RWF5; baseline and differential.
DR Genevisible; Q8RWF5; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR Pfam; PF01554; MatE; 2.
DR TIGRFAMs; TIGR00797; matE; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..483
FT /note="Protein DETOXIFICATION 6"
FT /id="PRO_0000405324"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 334..354
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 376..396
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 405..425
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 436..456
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 483 AA; 51933 MW; C140C419881FDC28 CRC64;
MEDPLLLGDN QIITGSLKPT PTWRMNFTAE LKNLSRMALP MATVTVAQYL LPVISVMVAG
HRSELQLSGV ALATSFTNVS GFSVMFGLAG ALETLCGQAY GAKQYAKIGT YTFSAIVSNV
PIVVLISILW FYMDKLFVSL GQDPDISKVA GSYAVCLIPA LLAQAVQQPL TRFLQTQGLV
LPLLYCAITT LLFHIPVCLI LVYAFGLGSN GAALAIGLSY WFNVLILALY VRFSSSCEKT
RGFVSDDFVL SVKQFFQYGI PSAAMTTIEW SLFEFLILSS GLLPNPKLET SVLSICLTTS
SLHYVIPMGI GAAGSIRVSN ELGAGNPEVA RLAVFAGIFL WFLEATICST LLFICRDIFG
YAFSNSKEVV DYVTELSPLL CISFLVDGFS AVLGGVARGS GWQHIGAWAN VVAYYLLGAP
VGLFLGFWCH MNGKGLWIGV VVGSTAQGII LAIVTACMSW NEQAAKARQR IVVRTSSFGN
GLA
