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DTX7_ARATH
ID   DTX7_ARATH              Reviewed;         502 AA.
AC   Q1PFG9; Q9XIR3;
DT   14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Protein DETOXIFICATION 7 {ECO:0000303|PubMed:11739388};
DE            Short=AtDTX7 {ECO:0000303|PubMed:11739388};
DE   AltName: Full=Multidrug and toxic compound extrusion protein 7 {ECO:0000305};
DE            Short=MATE protein 7 {ECO:0000305};
GN   Name=DTX7 {ECO:0000303|PubMed:11739388};
GN   OrderedLocusNames=At1g64820 {ECO:0000312|Araport:AT1G64820};
GN   ORFNames=F13O11.12 {ECO:0000312|EMBL:AAD38256.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA   Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT   "Simultaneous high-throughput recombinational cloning of open reading
RT   frames in closed and open configurations.";
RL   Plant Biotechnol. J. 4:317-324(2006).
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=11739388; DOI=10.1074/jbc.m108777200;
RA   Li L., He Z., Pandey G.K., Tsuchiya T., Luan S.;
RT   "Functional cloning and characterization of a plant efflux carrier for
RT   multidrug and heavy metal detoxification.";
RL   J. Biol. Chem. 277:5360-5368(2002).
RN   [5]
RP   GENE FAMILY.
RX   PubMed=12603313; DOI=10.1046/j.1432-1033.2003.03418.x;
RA   Hvorup R.N., Winnen B., Chang A.B., Jiang Y., Zhou X.F., Saier M.H. Jr.;
RT   "The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter
RT   superfamily.";
RL   Eur. J. Biochem. 270:799-813(2003).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAD38256.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC006193; AAD38256.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE34294.1; -; Genomic_DNA.
DR   EMBL; DQ446394; ABE65740.1; -; mRNA.
DR   PIR; D96671; D96671.
DR   RefSeq; NP_176662.1; NM_105156.1.
DR   AlphaFoldDB; Q1PFG9; -.
DR   SMR; Q1PFG9; -.
DR   IntAct; Q1PFG9; 12.
DR   STRING; 3702.AT1G64820.1; -.
DR   PaxDb; Q1PFG9; -.
DR   PRIDE; Q1PFG9; -.
DR   EnsemblPlants; AT1G64820.1; AT1G64820.1; AT1G64820.
DR   GeneID; 842790; -.
DR   Gramene; AT1G64820.1; AT1G64820.1; AT1G64820.
DR   KEGG; ath:AT1G64820; -.
DR   Araport; AT1G64820; -.
DR   TAIR; locus:2010926; AT1G64820.
DR   eggNOG; KOG1347; Eukaryota.
DR   HOGENOM; CLU_012893_1_0_1; -.
DR   InParanoid; Q1PFG9; -.
DR   OMA; AVMCCLE; -.
DR   OrthoDB; 743037at2759; -.
DR   PhylomeDB; Q1PFG9; -.
DR   PRO; PR:Q1PFG9; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q1PFG9; baseline and differential.
DR   Genevisible; Q1PFG9; AT.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR   CDD; cd13132; MATE_eukaryotic; 1.
DR   InterPro; IPR045069; MATE_euk.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..502
FT                   /note="Protein DETOXIFICATION 7"
FT                   /id="PRO_0000434050"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        208..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        262..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        291..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        331..351
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        375..395
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        408..428
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        436..456
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   502 AA;  55708 MW;  A44052AF5A5CDC01 CRC64;
     METDFSLVRK EEEEEEDNRN GMSYLSMEMM KKVSSMAAPM VAVSVSQFLL QVISMVMAGH
     LDELSLSAVA IATSLTNVTG FSLIVGFAGA LDTLCGQAFG AEQFGKIGAY TYSSMLCLLV
     FCFSISIVWF FMDKLLEIFH QDPLISQLAC RYSIWLIPAL FGFTLLQPMT RYFQSQGITL
     PLFVSSLGAL CFHIPFCWLL VYKLKFGIVG AALSIGFSYW LNVFLLWIFM RYSALHREMK
     NLGLQELISS MKQFIALAIP SAMMICLEWW SFEILLLMSG LLPNSKLETS VISICLTTSA
     VHFVLVNAIG ASASTHVSNE LGAGNHRAAR AAVNSAIFLG GVGALITTIT LYSYRKSWGY
     VFSNEREVVR YATQITPILC LSIFVNSFLA VLSGVARGSG WQRIGGYASL GSYYLVGIPL
     GWFLCFVMKL RGKGLWIGIL IASTIQLIVF ALVTFFTNWE QEATKARDRV FEMTPQVKGN
     QKTQIIVEED TQVLLNHIAE TV
 
 
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