DTX7_ARATH
ID DTX7_ARATH Reviewed; 502 AA.
AC Q1PFG9; Q9XIR3;
DT 14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Protein DETOXIFICATION 7 {ECO:0000303|PubMed:11739388};
DE Short=AtDTX7 {ECO:0000303|PubMed:11739388};
DE AltName: Full=Multidrug and toxic compound extrusion protein 7 {ECO:0000305};
DE Short=MATE protein 7 {ECO:0000305};
GN Name=DTX7 {ECO:0000303|PubMed:11739388};
GN OrderedLocusNames=At1g64820 {ECO:0000312|Araport:AT1G64820};
GN ORFNames=F13O11.12 {ECO:0000312|EMBL:AAD38256.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11739388; DOI=10.1074/jbc.m108777200;
RA Li L., He Z., Pandey G.K., Tsuchiya T., Luan S.;
RT "Functional cloning and characterization of a plant efflux carrier for
RT multidrug and heavy metal detoxification.";
RL J. Biol. Chem. 277:5360-5368(2002).
RN [5]
RP GENE FAMILY.
RX PubMed=12603313; DOI=10.1046/j.1432-1033.2003.03418.x;
RA Hvorup R.N., Winnen B., Chang A.B., Jiang Y., Zhou X.F., Saier M.H. Jr.;
RT "The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter
RT superfamily.";
RL Eur. J. Biochem. 270:799-813(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD38256.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC006193; AAD38256.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE34294.1; -; Genomic_DNA.
DR EMBL; DQ446394; ABE65740.1; -; mRNA.
DR PIR; D96671; D96671.
DR RefSeq; NP_176662.1; NM_105156.1.
DR AlphaFoldDB; Q1PFG9; -.
DR SMR; Q1PFG9; -.
DR IntAct; Q1PFG9; 12.
DR STRING; 3702.AT1G64820.1; -.
DR PaxDb; Q1PFG9; -.
DR PRIDE; Q1PFG9; -.
DR EnsemblPlants; AT1G64820.1; AT1G64820.1; AT1G64820.
DR GeneID; 842790; -.
DR Gramene; AT1G64820.1; AT1G64820.1; AT1G64820.
DR KEGG; ath:AT1G64820; -.
DR Araport; AT1G64820; -.
DR TAIR; locus:2010926; AT1G64820.
DR eggNOG; KOG1347; Eukaryota.
DR HOGENOM; CLU_012893_1_0_1; -.
DR InParanoid; Q1PFG9; -.
DR OMA; AVMCCLE; -.
DR OrthoDB; 743037at2759; -.
DR PhylomeDB; Q1PFG9; -.
DR PRO; PR:Q1PFG9; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q1PFG9; baseline and differential.
DR Genevisible; Q1PFG9; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR Pfam; PF01554; MatE; 2.
DR TIGRFAMs; TIGR00797; matE; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..502
FT /note="Protein DETOXIFICATION 7"
FT /id="PRO_0000434050"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 208..228
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..282
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 291..311
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 331..351
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 375..395
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 408..428
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 436..456
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 502 AA; 55708 MW; A44052AF5A5CDC01 CRC64;
METDFSLVRK EEEEEEDNRN GMSYLSMEMM KKVSSMAAPM VAVSVSQFLL QVISMVMAGH
LDELSLSAVA IATSLTNVTG FSLIVGFAGA LDTLCGQAFG AEQFGKIGAY TYSSMLCLLV
FCFSISIVWF FMDKLLEIFH QDPLISQLAC RYSIWLIPAL FGFTLLQPMT RYFQSQGITL
PLFVSSLGAL CFHIPFCWLL VYKLKFGIVG AALSIGFSYW LNVFLLWIFM RYSALHREMK
NLGLQELISS MKQFIALAIP SAMMICLEWW SFEILLLMSG LLPNSKLETS VISICLTTSA
VHFVLVNAIG ASASTHVSNE LGAGNHRAAR AAVNSAIFLG GVGALITTIT LYSYRKSWGY
VFSNEREVVR YATQITPILC LSIFVNSFLA VLSGVARGSG WQRIGGYASL GSYYLVGIPL
GWFLCFVMKL RGKGLWIGIL IASTIQLIVF ALVTFFTNWE QEATKARDRV FEMTPQVKGN
QKTQIIVEED TQVLLNHIAE TV