DTX8_ARATH
ID DTX8_ARATH Reviewed; 485 AA.
AC F4HQ05; Q9C9N0;
DT 14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=Protein DETOXIFICATION 8 {ECO:0000303|PubMed:11739388};
DE Short=AtDTX8 {ECO:0000303|PubMed:11739388};
DE AltName: Full=Multidrug and toxic compound extrusion protein 8 {ECO:0000305};
DE Short=MATE protein 8 {ECO:0000305};
GN Name=DTX8 {ECO:0000303|PubMed:11739388};
GN OrderedLocusNames=At1g66780 {ECO:0000312|Araport:AT1G66780};
GN ORFNames=F4N21_9 {ECO:0000312|EMBL:AAG60068.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11739388; DOI=10.1074/jbc.m108777200;
RA Li L., He Z., Pandey G.K., Tsuchiya T., Luan S.;
RT "Functional cloning and characterization of a plant efflux carrier for
RT multidrug and heavy metal detoxification.";
RL J. Biol. Chem. 277:5360-5368(2002).
RN [4]
RP GENE FAMILY.
RX PubMed=12603313; DOI=10.1046/j.1432-1033.2003.03418.x;
RA Hvorup R.N., Winnen B., Chang A.B., Jiang Y., Zhou X.F., Saier M.H. Jr.;
RT "The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter
RT superfamily.";
RL Eur. J. Biochem. 270:799-813(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG60068.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC013288; AAG60068.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE34555.1; -; Genomic_DNA.
DR RefSeq; NP_176850.2; NM_105349.3.
DR AlphaFoldDB; F4HQ05; -.
DR SMR; F4HQ05; -.
DR STRING; 3702.AT1G66780.1; -.
DR PaxDb; F4HQ05; -.
DR PRIDE; F4HQ05; -.
DR EnsemblPlants; AT1G66780.1; AT1G66780.1; AT1G66780.
DR GeneID; 842996; -.
DR Gramene; AT1G66780.1; AT1G66780.1; AT1G66780.
DR KEGG; ath:AT1G66780; -.
DR Araport; AT1G66780; -.
DR TAIR; locus:2033309; AT1G66780.
DR eggNOG; KOG1347; Eukaryota.
DR HOGENOM; CLU_012893_1_0_1; -.
DR InParanoid; F4HQ05; -.
DR OMA; CAYYIAG; -.
DR OrthoDB; 743037at2759; -.
DR PRO; PR:F4HQ05; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; F4HQ05; baseline and differential.
DR Genevisible; F4HQ05; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR Pfam; PF01554; MatE; 2.
DR TIGRFAMs; TIGR00797; matE; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..485
FT /note="Protein DETOXIFICATION 8"
FT /id="PRO_0000434051"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..94
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 297..317
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 338..358
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 381..401
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 414..434
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 442..462
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 485 AA; 53577 MW; 21A3455AC8669C88 CRC64;
MENGFSLVPK EEEEEEDYSN EKSEDQTSYY LSTEMMKKVS FMAAPMVAVA ASQYLLQVIS
IVMAGHLDEL SLSAVAIATS LTNVTGFSLI FGLAGALETL CGQAFGAGQF RNISAYTYGS
MLCLLLVCFP ISLLWVFMDK LLELFHQDPL ISQLACRYSI WLIPALFGYS VLQSMTRFFQ
SQGLVLPLFL SSLGALFFHV PFSWLLVYKL RFGIVGAALS IGFSYWLNVG LLWAFMRDSA
LYRKNWNLRA QEIFLSMKQF ITLAIPTAMM TCLEWWSFEL LILMSGLLPN SKLETSVLSI
CLTMSSLHYV IVNAIGAAAS THVSNKLGAG NPKAARSAAN SAIFLGMIDA AIVSISLYSY
RRNWAYIFSN ESEVADYVTQ ITPFLCLSIG VDSFLAVLSG VARGTGWQHI GAYANIGSYY
LVGIPVGSIL CFVVKLRGKG LWIGILVGST LQTIVLALVT FFTNWEQEVA KARDRVIEMI
PQEII
