ID   DTXR_CORDW              Reviewed;         226 AA.
AC   H2I233; P33120; Q5XQ41; Q5XQ42; Q5XQ43;
DT   05-SEP-2012, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2012, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Diphtheria toxin repressor;
DE   AltName: Full=Iron-dependent diphtheria tox regulatory element;
DE   AltName: Full=Tox regulatory factor;
GN   Name=dtxR; OrderedLocusNames=CDPW8_1404;
OS   Corynebacterium diphtheriae (strain PW8).
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=698964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=PW8;
RX   PubMed=1735717; DOI=10.1128/jb.174.4.1268-1272.1992;
RA   Boyd J.M., Hall K.C., Murphy J.R.;
RT   "DNA sequences and characterization of dtxR alleles from Corynebacterium
RT   diphtheriae PW8(-), 1030(-), and C7hm723(-).";
RL   J. Bacteriol. 174:1268-1272(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PW8;
RX   PubMed=22505676; DOI=10.1128/jb.00183-12;
RA   Trost E., Blom J., de Castro Soares S., Huang I.H., Al-Dilaimi A.,
RA   Schroder J., Jaenicke S., Dorella F.A., Rocha F.S., Miyoshi A., Azevedo V.,
RA   Schneider M.P., Silva A., Camello T.C., Sabbadini P.S., Santos C.S.,
RA   Santos L.S., Hirata R. Jr., Mattos-Guaraldi A.L., Efstratiou A.,
RA   Schmitt M.P., Ton-That H., Tauch A.;
RT   "Pangenomic study of Corynebacterium diphtheriae that provides insights
RT   into the genomic diversity of pathogenic isolates from cases of classical
RT   diphtheria, endocarditis, and pneumonia.";
RL   J. Bacteriol. 194:3199-3215(2012).
CC   -!- FUNCTION: Iron-binding repressor of the dipheteria toxin gene
CC       expression. May serve as a global regulator of gene expression.
CC       Represses ripA under iron excess (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DtxR/MntR family. {ECO:0000305}.
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DR   EMBL; M80338; AAA23299.1; -; Genomic_DNA.
DR   EMBL; CP003216; AEX70059.1; -; Genomic_DNA.
DR   PIR; A35968; A35968.
DR   RefSeq; WP_003851803.1; NC_016789.1.
DR   AlphaFoldDB; H2I233; -.
DR   BMRB; H2I233; -.
DR   SMR; H2I233; -.
DR   GeneID; 29421139; -.
DR   KEGG; cdw:CDPW8_1404; -.
DR   PATRIC; fig|698964.3.peg.1462; -.
DR   HOGENOM; CLU_069532_0_0_11; -.
DR   OMA; NIIPACD; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.60.10; -; 1.
DR   Gene3D; 2.30.30.90; -; 1.
DR   InterPro; IPR040767; DtxR_SH3.
DR   InterPro; IPR001367; Fe_dep_repressor.
DR   InterPro; IPR036421; Fe_dep_repressor_sf.
DR   InterPro; IPR038157; FeoA_core_dom.
DR   InterPro; IPR022687; HTH_DTXR.
DR   InterPro; IPR022689; Iron_dep_repressor.
DR   InterPro; IPR008988; Transcriptional_repressor_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF18357; DtxR; 1.
DR   Pfam; PF02742; Fe_dep_repr_C; 1.
DR   Pfam; PF01325; Fe_dep_repress; 1.
DR   SMART; SM00529; HTH_DTXR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47979; SSF47979; 1.
DR   SUPFAM; SSF50037; SSF50037; 1.
DR   PROSITE; PS50944; HTH_DTXR; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Iron; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..226
FT                   /note="Diphtheria toxin repressor"
FT                   /id="PRO_0000418420"
FT   DOMAIN          4..65
FT                   /note="HTH dtxR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00296"
SQ   SEQUENCE   226 AA;  25316 MW;  6EA8C1525B709D4E CRC64;
     MKDLVDTTEM YLRTIYELEE EGVTPLRARI AERLEQSGPT VSQTVARMER DGLVVVASDR
     SLQMTPTGRT LATAVMRKHR LAERLLTDII GLDINKVHDE ACRWEHVMSD EVERRLVKVL
     KDVSRSPFGN PIPGLDELGV GNSDAAAPGT RVIDAATSMP RKVRIVQINE IFQVETDQFT
     QLLDADIRVG SEVEIVDRDG HITLSHNGKD VELLDDLAHT IRIEEL