ID   DTXR_COREF              Reviewed;         230 AA.
AC   Q8FPG6;
DT   07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 2.
DT   25-MAY-2022, entry version 112.
DE   RecName: Full=Diphtheria toxin repressor;
DE   AltName: Full=Iron-dependent diphtheria tox regulatory element;
DE   AltName: Full=Tox regulatory factor;
GN   Name=dtxR; OrderedLocusNames=CE1812;
OS   Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189
OS   / NBRC 100395).
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=196164;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395;
RX   PubMed=12840036; DOI=10.1101/gr.1285603;
RA   Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S.,
RA   Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.;
RT   "Comparative complete genome sequence analysis of the amino acid
RT   replacements responsible for the thermostability of Corynebacterium
RT   efficiens.";
RL   Genome Res. 13:1572-1579(2003).
CC   -!- FUNCTION: Iron-binding repressor of the dipheteria toxin gene
CC       expression. May serve as a global regulator of gene expression.
CC       Represses ripA under iron excess (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DtxR/MntR family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC18622.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BA000035; BAC18622.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_006767811.1; NZ_GG700683.1.
DR   AlphaFoldDB; Q8FPG6; -.
DR   SMR; Q8FPG6; -.
DR   STRING; 196164.23493653; -.
DR   EnsemblBacteria; BAC18622; BAC18622; BAC18622.
DR   KEGG; cef:CE1812; -.
DR   eggNOG; COG1321; Bacteria.
DR   HOGENOM; CLU_069532_0_0_11; -.
DR   OrthoDB; 2047422at2; -.
DR   Proteomes; UP000001409; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.60.10; -; 1.
DR   Gene3D; 2.30.30.90; -; 1.
DR   InterPro; IPR040767; DtxR_SH3.
DR   InterPro; IPR007167; Fe-transptr_FeoA.
DR   InterPro; IPR001367; Fe_dep_repressor.
DR   InterPro; IPR036421; Fe_dep_repressor_sf.
DR   InterPro; IPR038157; FeoA_core_dom.
DR   InterPro; IPR022687; HTH_DTXR.
DR   InterPro; IPR022689; Iron_dep_repressor.
DR   InterPro; IPR008988; Transcriptional_repressor_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF18357; DtxR; 1.
DR   Pfam; PF02742; Fe_dep_repr_C; 1.
DR   Pfam; PF01325; Fe_dep_repress; 1.
DR   SMART; SM00899; FeoA; 1.
DR   SMART; SM00529; HTH_DTXR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47979; SSF47979; 1.
DR   SUPFAM; SSF50037; SSF50037; 1.
DR   PROSITE; PS50944; HTH_DTXR; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Iron; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..230
FT                   /note="Diphtheria toxin repressor"
FT                   /id="PRO_0000223183"
FT   DOMAIN          4..65
FT                   /note="HTH dtxR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00296"
SQ   SEQUENCE   230 AA;  25920 MW;  19FC83CB7CD4BAE9 CRC64;
     MKDLVDTTEM YLRTIYELEE EGIVPLRARI AERLEQSGPT VSQTVARMER DGLVHVSPDR
     SLEMTPEGRA LAIAVMRKHR LAERLLTDII GLDIHKVHDE ACRWEHVMSD EVERRLVEVL
     DDVTRSPFGN PIPGLADIGL DQDREPDSGI RAIDLPHGES LRVRIVQLNE ILQVDQEQFS
     ILSSAGIRIG TEVDIINEQG RVVITHNGMM VELMDDLAHA VRVEKVDGLN