ID   DTXR_CORGL              Reviewed;         228 AA.
AC   Q8NP95; Q46067; Q6M4A1;
DT   07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Diphtheria toxin repressor;
DE   AltName: Full=Iron-dependent diphtheria tox regulatory element;
DE   AltName: Full=Tox regulatory factor;
GN   Name=dtxR; OrderedLocusNames=Cgl1920, cg2103;
OS   Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 /
OS   JCM 1318 / LMG 3730 / NCIMB 10025).
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=196627;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 13869 / DSMZ 1412 / NCIMB 9567;
RX   PubMed=7814338; DOI=10.1128/jb.177.2.465-467.1995;
RA   Oguiza J.A., Tao X., Marcos A.T., Martin J.F., Murphy J.R.;
RT   "Molecular cloning, DNA sequence analysis, and characterization of the
RT   Corynebacterium diphtheriae dtxR homolog from Brevibacterium
RT   lactofermentum.";
RL   J. Bacteriol. 177:465-467(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB
RC   10025;
RX   PubMed=12743753; DOI=10.1007/s00253-003-1328-1;
RA   Ikeda M., Nakagawa S.;
RT   "The Corynebacterium glutamicum genome: features and impacts on
RT   biotechnological processes.";
RL   Appl. Microbiol. Biotechnol. 62:99-109(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB
RC   10025;
RX   PubMed=12948626; DOI=10.1016/s0168-1656(03)00154-8;
RA   Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M., Burkovski A.,
RA   Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L., Goesmann A.,
RA   Hartmann M., Huthmacher K., Kraemer R., Linke B., McHardy A.C., Meyer F.,
RA   Moeckel B., Pfefferle W., Puehler A., Rey D.A., Rueckert C., Rupp O.,
RA   Sahm H., Wendisch V.F., Wiegraebe I., Tauch A.;
RT   "The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its
RT   impact on the production of L-aspartate-derived amino acids and vitamins.";
RL   J. Biotechnol. 104:5-25(2003).
RN   [4]
RP   REPRESSION OF RIPA.
RC   STRAIN=ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB
RC   10025;
RX   PubMed=16179344; DOI=10.1074/jbc.m508693200;
RA   Wennerhold J., Krug A., Bott M.;
RT   "The AraC-type regulator RipA represses aconitase and other iron proteins
RT   from Corynebacterium under iron limitation and is itself repressed by
RT   DtxR.";
RL   J. Biol. Chem. 280:40500-40508(2005).
CC   -!- FUNCTION: Iron-binding repressor of the dipheteria toxin gene
CC       expression. May serve as a global regulator of gene expression (By
CC       similarity). Represses ripA under iron excess. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the DtxR/MntR family. {ECO:0000305}.
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DR   EMBL; L35906; AAA91345.1; -; Genomic_DNA.
DR   EMBL; BA000036; BAB99313.1; -; Genomic_DNA.
DR   EMBL; BX927153; CAF20261.1; -; Genomic_DNA.
DR   PIR; I40339; I40339.
DR   RefSeq; NP_601126.1; NC_003450.3.
DR   RefSeq; WP_011014753.1; NC_006958.1.
DR   AlphaFoldDB; Q8NP95; -.
DR   SMR; Q8NP95; -.
DR   STRING; 196627.cg2103; -.
DR   KEGG; cgb:cg2103; -.
DR   KEGG; cgl:Cgl1920; -.
DR   PATRIC; fig|196627.13.peg.1858; -.
DR   eggNOG; COG1321; Bacteria.
DR   HOGENOM; CLU_069532_0_0_11; -.
DR   OMA; NIIPACD; -.
DR   Proteomes; UP000000582; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.60.10; -; 1.
DR   Gene3D; 2.30.30.90; -; 1.
DR   InterPro; IPR040767; DtxR_SH3.
DR   InterPro; IPR007167; Fe-transptr_FeoA.
DR   InterPro; IPR001367; Fe_dep_repressor.
DR   InterPro; IPR036421; Fe_dep_repressor_sf.
DR   InterPro; IPR038157; FeoA_core_dom.
DR   InterPro; IPR022687; HTH_DTXR.
DR   InterPro; IPR022689; Iron_dep_repressor.
DR   InterPro; IPR008988; Transcriptional_repressor_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF18357; DtxR; 1.
DR   Pfam; PF02742; Fe_dep_repr_C; 1.
DR   Pfam; PF01325; Fe_dep_repress; 1.
DR   SMART; SM00899; FeoA; 1.
DR   SMART; SM00529; HTH_DTXR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47979; SSF47979; 1.
DR   SUPFAM; SSF50037; SSF50037; 1.
DR   PROSITE; PS50944; HTH_DTXR; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Iron; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..228
FT                   /note="Diphtheria toxin repressor"
FT                   /id="PRO_0000223184"
FT   DOMAIN          4..65
FT                   /note="HTH dtxR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00296"
FT   VARIANT         78..79
FT                   /note="KH -> ND (in strain: ATCC 13869)"
SQ   SEQUENCE   228 AA;  25485 MW;  5DE2DF6059D7DF22 CRC64;
     MKDLVDTTEM YLRTIYELEE EGIVPLRARI AERLEQSGPT VSQTVARMER DGLVHVSPDR
     SLEMTPEGRS LAIAVMRKHR LAERLLTDII GLDIHKVHDE ACRWEHVMSD EVERRLVEVL
     DDVHRSPFGN PIPGLGEIGL DQADEPDSGV RAIDLPLGEN LKARIVQLNE ILQVDLEQFQ
     ALTDAGVEIG TEVDIINEQG RVVITHNGSS VELIDDLAHA VRVEKVEG