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DTXR_CORJK
ID   DTXR_CORJK              Reviewed;         240 AA.
AC   Q4JV96;
DT   07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Diphtheria toxin repressor;
DE   AltName: Full=Iron-dependent diphtheria tox regulatory element;
DE   AltName: Full=Tox regulatory factor;
GN   Name=dtxR; OrderedLocusNames=jk1097;
OS   Corynebacterium jeikeium (strain K411).
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=306537;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K411;
RX   PubMed=15968079; DOI=10.1128/jb.187.13.4671-4682.2005;
RA   Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A.,
RA   Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F.,
RA   Rupp O., Schneiker S., Viehoever P., Puehler A.;
RT   "Complete genome sequence and analysis of the multiresistant nosocomial
RT   pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the
RT   human skin flora.";
RL   J. Bacteriol. 187:4671-4682(2005).
CC   -!- FUNCTION: Iron-binding repressor of the dipheteria toxin gene
CC       expression. May serve as a global regulator of gene expression (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DtxR/MntR family. {ECO:0000305}.
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DR   EMBL; CR931997; CAI37261.1; -; Genomic_DNA.
DR   RefSeq; WP_011273648.1; NC_007164.1.
DR   AlphaFoldDB; Q4JV96; -.
DR   SMR; Q4JV96; -.
DR   STRING; 306537.jk1097; -.
DR   EnsemblBacteria; CAI37261; CAI37261; jk1097.
DR   GeneID; 56649536; -.
DR   KEGG; cjk:jk1097; -.
DR   PATRIC; fig|306537.10.peg.1110; -.
DR   eggNOG; COG1321; Bacteria.
DR   HOGENOM; CLU_069532_0_0_11; -.
DR   OMA; IGLPWEK; -.
DR   OrthoDB; 2047422at2; -.
DR   Proteomes; UP000000545; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.60.10; -; 1.
DR   Gene3D; 2.30.30.90; -; 1.
DR   InterPro; IPR040767; DtxR_SH3.
DR   InterPro; IPR001367; Fe_dep_repressor.
DR   InterPro; IPR036421; Fe_dep_repressor_sf.
DR   InterPro; IPR038157; FeoA_core_dom.
DR   InterPro; IPR022687; HTH_DTXR.
DR   InterPro; IPR022689; Iron_dep_repressor.
DR   InterPro; IPR008988; Transcriptional_repressor_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF18357; DtxR; 1.
DR   Pfam; PF02742; Fe_dep_repr_C; 1.
DR   Pfam; PF01325; Fe_dep_repress; 1.
DR   SMART; SM00529; HTH_DTXR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47979; SSF47979; 1.
DR   SUPFAM; SSF50037; SSF50037; 1.
DR   PROSITE; PS50944; HTH_DTXR; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Iron; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..240
FT                   /note="Diphtheria toxin repressor"
FT                   /id="PRO_0000223185"
FT   DOMAIN          1..65
FT                   /note="HTH dtxR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00296"
SQ   SEQUENCE   240 AA;  26964 MW;  74319E88EC0B1A4C CRC64;
     MRDLVDTTEM YLRTIYELEE EGIPPLRARI AERLDQSGPT VSQTVARMER DELLTVEKDR
     SLKLSAQGRA LATAVMRKHR LAERLLTDVI GLPWEKVHDE ACRWEHVMGD EVEVQLVKVL
     SEYATSPFGN PIPGLDELME GIPDSERAEL QQKIDNLQVV TSQRASDIEP PEPIQVKILS
     INEIIQVEHK LMAKFHALGM RPGSVVDLVA TEDGLEFSND NGAMVVPEEL GHAVRVEKVN
 
 
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