DUF7_ARATH
ID DUF7_ARATH Reviewed; 722 AA.
AC Q8H0V4; B9DHM6; Q9M1P4;
DT 08-JUN-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 114.
DE RecName: Full=DUF724 domain-containing protein 7 {ECO:0000305};
DE Short=AtDUF7 {ECO:0000303|PubMed:19795213};
DE AltName: Full=ABAP1-interacting protein 1 {ECO:0000303|PubMed:26538092};
GN Name=DUF7 {ECO:0000303|PubMed:19795213};
GN Synonyms=AIP1 {ECO:0000303|PubMed:26538092};
GN OrderedLocusNames=At3g62300 {ECO:0000312|Araport:AT3G62300};
GN ORFNames=T17J13.260 {ECO:0000312|EMBL:CAB71890.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 262-722.
RC STRAIN=cv. Columbia;
RX PubMed=19423640; DOI=10.1093/dnares/dsp009;
RA Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M.,
RA Shinozaki K.;
RT "Analysis of multiple occurrences of alternative splicing events in
RT Arabidopsis thaliana using novel sequenced full-length cDNAs.";
RL DNA Res. 16:155-164(2009).
RN [5]
RP FUNCTION, GENE FAMILY, NOMENCLATURE, SUBUNIT, SUBCELLULAR LOCATION, AND
RP TISSUE SPECIFICITY.
RX PubMed=19795213; DOI=10.1007/s11103-009-9551-5;
RA Cao X., Yang K.Z., Xia C., Zhang X.Q., Chen L.Q., Ye D.;
RT "Characterization of DUF724 gene family in Arabidopsis thaliana.";
RL Plant Mol. Biol. 72:61-73(2010).
RN [6]
RP SUBUNIT, INTERACTION WITH ABAP1; ARIA AND LHP1, SUBCELLULAR LOCATION, AND
RP DEVELOPMENTAL STAGE.
RX PubMed=26538092; DOI=10.1186/s12870-015-0641-z;
RA Brasil J.N., Cabral L.M., Eloy N.B., Primo L.M., Barroso-Neto I.L.,
RA Grangeiro L.P., Gonzalez N., Inze D., Ferreira P.C., Hemerly A.S.;
RT "AIP1 is a novel Agenet/Tudor domain protein from Arabidopsis that
RT interacts with regulators of DNA replication, transcription and chromatin
RT remodeling.";
RL BMC Plant Biol. 15:270-270(2015).
CC -!- FUNCTION: May act as a link between DNA replication, transcription and
CC chromatin remodeling during flower development. May participate in the
CC repression of LHP1-targeted genes during flower development by direct
CC interaction with LHP1 (PubMed:26538092). May be involved in the polar
CC growth of plant cells via transportation of RNAs (Probable).
CC {ECO:0000269|PubMed:26538092, ECO:0000305|PubMed:19795213}.
CC -!- SUBUNIT: Homodimer (PubMed:19795213, PubMed:26538092). Interacts wtih
CC ABAP1, ARIA and LHP1 (PubMed:26538092). Interacts with the non-modified
CC histones H1, H2B, H3 and H4 (PubMed:26538092).
CC {ECO:0000269|PubMed:19795213, ECO:0000269|PubMed:26538092}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19795213,
CC ECO:0000269|PubMed:26538092}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences. {ECO:0000305};
CC Name=1;
CC IsoId=Q8H0V4-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Expressed in roots, leaves, stems and flowers.
CC {ECO:0000269|PubMed:19795213}.
CC -!- DEVELOPMENTAL STAGE: Expressed during vegetative to reproductive phase
CC of development, with the main expression occurring in early flower
CC development. {ECO:0000269|PubMed:26538092}.
CC -!- MISCELLANEOUS: Plants with reduced expression of DUF7 show a slight
CC delay in flowering. {ECO:0000269|PubMed:26538092}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB71890.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL138651; CAB71890.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE80335.1; -; Genomic_DNA.
DR EMBL; BT002019; AAN72030.1; -; mRNA.
DR EMBL; AK317579; BAH20243.1; -; mRNA.
DR PIR; T48022; T48022.
DR RefSeq; NP_191789.2; NM_116095.3. [Q8H0V4-1]
DR AlphaFoldDB; Q8H0V4; -.
DR SMR; Q8H0V4; -.
DR STRING; 3702.AT3G62300.2; -.
DR iPTMnet; Q8H0V4; -.
DR PRIDE; Q8H0V4; -.
DR ProteomicsDB; 222225; -. [Q8H0V4-1]
DR EnsemblPlants; AT3G62300.1; AT3G62300.1; AT3G62300. [Q8H0V4-1]
DR GeneID; 825403; -.
DR Gramene; AT3G62300.1; AT3G62300.1; AT3G62300. [Q8H0V4-1]
DR KEGG; ath:AT3G62300; -.
DR Araport; AT3G62300; -.
DR eggNOG; ENOG502QTQX; Eukaryota.
DR HOGENOM; CLU_007138_1_0_1; -.
DR PhylomeDB; Q8H0V4; -.
DR PRO; PR:Q8H0V4; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q8H0V4; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.
DR GO; GO:0009908; P:flower development; IEA:UniProtKB-KW.
DR GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR InterPro; IPR008395; Agenet-like_dom.
DR InterPro; IPR014002; Agenet_dom_plant.
DR InterPro; IPR007930; DUF724.
DR Pfam; PF05641; Agenet; 2.
DR Pfam; PF05266; DUF724; 1.
DR SMART; SM00743; Agenet; 4.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Flowering; Growth regulation; Nucleus;
KW Reference proteome; Transport.
FT CHAIN 1..722
FT /note="DUF724 domain-containing protein 7"
FT /id="PRO_0000436425"
FT DOMAIN 540..720
FT /note="DUF724"
FT /evidence="ECO:0000255"
FT REGION 424..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 645..712
FT /evidence="ECO:0000255"
FT COMPBIAS 425..447
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 452
FT /note="N -> Y (in Ref. 4; BAH20243)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 722 AA; 80740 MW; A4170CD609A4AD14 CRC64;
MLLTTGRKEK LSVSKGSEIE ISSQEYEYGS GNVWYCVILE ENLAKSKRKK LSVRHLDPLL
KYDYSPPLIK TTVHRFMRPV PPPDPFPEVD FEEGDVVDAA YKGGWCSGSV VKVLGNRRFL
VYLRFQPDVI ELLRKDLRPH FVWKDEEWFR CEKQQLIESD FSAGKSVEVR TKVDKLGDVW
APAMVIKEDE DGTMLVKLKT LKEEEVNCTK ISVSYSEIRP SPLPIGLRDY KLMENVDALV
ESGWCPGVVS KVLAGKRYAV DLGPNRESKE FSRLQLRPSI EWKDGIWHRK EKVSGSEESS
HAVEETAAST RIRITVRTAL KEKKALGTGI NVRTTRSSSG AMHNPLPASF NGGDVAEAGR
VSVTVNETPL FETAALSGEL GNSLADVVMN ESAPVTSQPE IAAPKEFHPS VVLGVAAAVK
TQGKTTPKKK LQAMKNQKSS TNDSVGEKVS VNKRKRGQPR KFIVAEPKQK IGVSGNNSKA
ATIEHADMTD DDRPLASWVH TGNSSSGQSV SRTPDIGLNT VVEKHVDIVE TPPGRESTMV
LPFVKKSQLW KVLESMEVFK VVPQSPHFSP LLESEEECRE GDAIGRMVMF SSLLEKVNNL
QVDDPISSIN RIDECFLKLE KHGFNVTTPR SRIAKILSIK ERQTCALEEL KAVEEKITEN
DNKRRKYEED IVELQRQEVL MKEAKVTLDN EIARMQSQAA VLDQEVQNVD HEFQAILAAP
WK
