DUF8_ARATH
ID DUF8_ARATH Reviewed; 421 AA.
AC F4KEA4; Q9FFA3;
DT 08-JUN-2016, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 68.
DE RecName: Full=DUF724 domain-containing protein 8 {ECO:0000305};
DE Short=AtDUF8 {ECO:0000303|PubMed:19795213};
GN Name=DUF8 {ECO:0000303|PubMed:19795213};
GN OrderedLocusNames=At5g23770 {ECO:0000312|Araport:AT5G23770};
GN ORFNames=MRO11.19 {ECO:0000312|EMBL:BAB10050.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9330910; DOI=10.1093/dnares/4.3.215;
RA Sato S., Kotani H., Nakamura Y., Kaneko T., Asamizu E., Fukami M.,
RA Miyajima N., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. I. Sequence
RT features of the 1.6 Mb regions covered by twenty physically assigned P1
RT clones.";
RL DNA Res. 4:215-230(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP FUNCTION, GENE FAMILY, NOMENCLATURE, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=19795213; DOI=10.1007/s11103-009-9551-5;
RA Cao X., Yang K.Z., Xia C., Zhang X.Q., Chen L.Q., Ye D.;
RT "Characterization of DUF724 gene family in Arabidopsis thaliana.";
RL Plant Mol. Biol. 72:61-73(2010).
CC -!- FUNCTION: May be involved in the polar growth of plant cells via
CC transportation of RNAs. {ECO:0000305|PubMed:19795213}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19795213}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences. {ECO:0000305};
CC Name=1;
CC IsoId=F4KEA4-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Expressed in leaves and flowers, and at lower
CC levels in roots, stems and siliques. {ECO:0000269|PubMed:19795213}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions. {ECO:0000269|PubMed:19795213}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB10050.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB005244; BAB10050.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; F4KEA4; -.
DR SMR; F4KEA4; -.
DR PRIDE; F4KEA4; -.
DR ProteomicsDB; 222185; -. [F4KEA4-1]
DR EnsemblPlants; AT5G23770.2; AT5G23770.2; AT5G23770.
DR Gramene; AT5G23770.2; AT5G23770.2; AT5G23770.
DR Araport; AT5G23770; -.
DR eggNOG; ENOG502QTQX; Eukaryota.
DR HOGENOM; CLU_007138_1_1_1; -.
DR PRO; PR:F4KEA4; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; F4KEA4; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR InterPro; IPR008395; Agenet-like_dom.
DR InterPro; IPR014002; Agenet_dom_plant.
DR InterPro; IPR007930; DUF724.
DR Pfam; PF05641; Agenet; 1.
DR Pfam; PF05266; DUF724; 1.
DR SMART; SM00743; Agenet; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Growth regulation; Nucleus;
KW Reference proteome; Transport.
FT CHAIN 1..421
FT /note="DUF724 domain-containing protein 8"
FT /id="PRO_0000436426"
FT DOMAIN 246..420
FT /note="DUF724"
FT /evidence="ECO:0000255"
FT REGION 149..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 361..397
FT /evidence="ECO:0000255"
FT COMPBIAS 149..166
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..229
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 421 AA; 47887 MW; 64A3BED43A36476E CRC64;
MFSPGTMVEV SSKINEGEVV WVPSMVIKEF KEDDEYKYIV KDKSFSCEGK KARPNKTVDL
SSLRPIPVSV DEYQLEENVE VFLDGMGWRH GRVMGSQERA IGTLSQKWYF VRLESTKKQL
TFKQSDLRPL KVWEDGVWKV LQTRELSFTQ GSGDKTGDSV RNANESDPPL TPPPGIITPP
LKQIEAGTQR KALSKKTLPR NQNGSGNDST LENENSEDNN RKRKREENLG CVASVEQDKP
KDTTMVLPFE KKLRIWETLE SMEVFKTVPQ SPHFSPLLVE SREDSREMSA VGMMLTFFGL
LDEVKALQHN DPISFFISLT NSFAELEKHG FNVKAPQSRI NKLLSLRDRQ SKKTEELKDA
EKVTAEKESV KAENKRKILE LQRLNEEMDK EIAQSKSCAA KIVQQLDDVK LEFLATASAP
W