DUR31_SCHPO
ID DUR31_SCHPO Reviewed; 664 AA.
AC O94469;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 115.
DE RecName: Full=Probable urea active transporter 1;
GN Name=dur3-1; ORFNames=SPBC23G7.13c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Involved in active transport of urea. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21)
CC family. {ECO:0000305}.
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DR EMBL; CU329671; CAA22629.1; -; Genomic_DNA.
DR PIR; T39959; T39959.
DR RefSeq; NP_595871.1; NM_001021777.2.
DR AlphaFoldDB; O94469; -.
DR SMR; O94469; -.
DR BioGRID; 277055; 4.
DR STRING; 4896.SPBC23G7.13c.1; -.
DR PaxDb; O94469; -.
DR EnsemblFungi; SPBC23G7.13c.1; SPBC23G7.13c.1:pep; SPBC23G7.13c.
DR GeneID; 2540527; -.
DR KEGG; spo:SPBC23G7.13c; -.
DR PomBase; SPBC23G7.13c; -.
DR VEuPathDB; FungiDB:SPBC23G7.13c; -.
DR eggNOG; KOG2348; Eukaryota.
DR HOGENOM; CLU_010778_2_1_1; -.
DR InParanoid; O94469; -.
DR OMA; WIFCSFI; -.
DR PhylomeDB; O94469; -.
DR PRO; PR:O94469; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISO:PomBase.
DR GO; GO:0015489; F:putrescine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015606; F:spermidine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015204; F:urea transmembrane transporter activity; ISO:PomBase.
DR GO; GO:0015847; P:putrescine transport; IBA:GO_Central.
DR GO; GO:0015848; P:spermidine transport; IBA:GO_Central.
DR GO; GO:0071918; P:urea transmembrane transport; ISO:PomBase.
DR GO; GO:0015840; P:urea transport; IBA:GO_Central.
DR Gene3D; 1.20.1730.10; -; 1.
DR InterPro; IPR031155; DUR.
DR InterPro; IPR038377; Na/Glc_symporter_sf.
DR InterPro; IPR001734; Na/solute_symporter.
DR PANTHER; PTHR46154; PTHR46154; 1.
DR Pfam; PF00474; SSF; 1.
DR TIGRFAMs; TIGR00813; sss; 1.
DR PROSITE; PS50283; NA_SOLUT_SYMP_3; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..664
FT /note="Probable urea active transporter 1"
FT /id="PRO_0000314766"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 252..272
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..310
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 327..347
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 353..373
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 395..415
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 428..448
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 454..474
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 496..516
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 555..575
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 587..607
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 664 AA; 71720 MW; 47BF73570FD30214 CRC64;
MVQPELTQSV GYGIVVGLGL GFAALMIFVS WSLKKFNNEN QTSEHFNTAS HSVRTGLVAS
AVVSSWTWAS TLLTSAQKTY QYGVSGAFWY ASGACVQILL FTVLAIELKR KAPNAHTFLE
VVRARCGPIA HGVFLVFAYI TNILVMAMLL CGGSATISSV TGMNTVAVCF LLPVGVIIYT
MFGGIKATFL TDYIHTVIIL VILIMFSLAT YSADKKIGSP GKLYDMLKEA GDAHPVAGNA
QGSYLTMRSQ EGAIFFIINL AGNFGTVFVD NGYWQKAIAA NPASALPGYI LGGLAWFAIP
WLAATTMGLV ALGLENKPYF PTYPNRMSDL EVSEGLVLPY AAIALMGRAG ANATLLLVFM
AVTSAASAEL IAVSSIFTYD IYKQYVRPRA TGKELLYTGH ASLIVFGFAM SGFATGLYYG
QVSMGYLYLL MGVLVCPAVV PATCVMLFSR VSTIAVTVSP VLGIISSIIT WLVVARAEGG
KTLTIETTGA NNPMLAGNVV GLLSPALYIL ILSIIFPEKY DFNRLLATFA MHFSSEEDEI
QQTKKLNRAS VISKVAALII TAAFIILWPW PMYGTGYIFS KRFFTGWVVV GLIWIFFTVF
AVGIFPLWEG RNDIYQVVSN MAASIFGRKV NDIVEDEGVV VETISIGSGS KEKVNFEKKD
IESV
