DUR32_SCHPO
ID DUR32_SCHPO Reviewed; 673 AA.
AC Q8TFG0;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 25-MAY-2022, entry version 96.
DE RecName: Full=Probable urea active transporter 2;
GN Name=dur3-2; ORFNames=SPAP8B6.02c, SPAPB8B6.02c, SPBPB8B6.02c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Involved in active transport of urea. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
CC membrane protein.
CC -!- SIMILARITY: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21)
CC family. {ECO:0000305}.
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DR EMBL; CU329671; CAD27908.1; -; Genomic_DNA.
DR RefSeq; NP_001018763.1; NM_001020938.2.
DR AlphaFoldDB; Q8TFG0; -.
DR SMR; Q8TFG0; -.
DR STRING; 4896.SPBPB8B6.02c.1; -.
DR PaxDb; Q8TFG0; -.
DR EnsemblFungi; SPBPB8B6.02c.1; SPBPB8B6.02c.1:pep; SPBPB8B6.02c.
DR GeneID; 3361185; -.
DR KEGG; spo:SPBPB8B6.02c; -.
DR PomBase; SPBPB8B6.02c; -.
DR VEuPathDB; FungiDB:SPBPB8B6.02c; -.
DR eggNOG; KOG2348; Eukaryota.
DR HOGENOM; CLU_010778_2_1_1; -.
DR InParanoid; Q8TFG0; -.
DR OMA; SAWTWPA; -.
DR PhylomeDB; Q8TFG0; -.
DR PRO; PR:Q8TFG0; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISO:PomBase.
DR GO; GO:0015489; F:putrescine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015606; F:spermidine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015204; F:urea transmembrane transporter activity; ISO:PomBase.
DR GO; GO:0015847; P:putrescine transport; IBA:GO_Central.
DR GO; GO:0015848; P:spermidine transport; IBA:GO_Central.
DR GO; GO:0071918; P:urea transmembrane transport; ISO:PomBase.
DR GO; GO:0015840; P:urea transport; IBA:GO_Central.
DR Gene3D; 1.20.1730.10; -; 1.
DR InterPro; IPR031155; DUR.
DR InterPro; IPR038377; Na/Glc_symporter_sf.
DR InterPro; IPR001734; Na/solute_symporter.
DR PANTHER; PTHR46154; PTHR46154; 1.
DR Pfam; PF00474; SSF; 1.
DR PROSITE; PS50283; NA_SOLUT_SYMP_3; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..673
FT /note="Probable urea active transporter 2"
FT /id="PRO_0000314767"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..218
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..307
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 336..356
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 391..411
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 424..446
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 451..471
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 492..512
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 559..579
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 592..612
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 673 AA; 72604 MW; 406931E32F9F0041 CRC64;
MEPILNQGYG YGFALGLGAA FALLMAIITK VLTACMGQTQ NSERFSTASR SVKSGLISSS
TVSAWTWPAT LLSSGAWSYT YGIMGGFMYG VGGTIQITLF LFLAIQIKKK APAAHTVSEC
FFIRFGKLGH CVYLFYCIST NVLVSSLLLL GGSQGFSSTT GMNTVAACFL LPLGVMVYTT
LGGLKATFIS DWIHTVMIYI ILIVTCYTVY CSSSLIGSPA KMYDMLKEVQ EVYPATGGQS
YLSFKNSEMM YLTWSVMIGG LSSVFGDPGY SQRAIASDAK SVFQGYLMGG LCWWIIPMAL
GSSAGLACRA LLLNPASVTY PNVLSSVEIS SGLPVIYGMA SIFGKSGAAA GLVMLFMSIT
SATSAELIAF SSVTTYDIFR AYINPAANGK QLVRTAHLSV IGFSLFIGAL SVGFNYAGVT
AGWLLTFLGI ILTPEVSAVT LCLFWNKMTR FSLVVGAPFG TITGVVCWLA STYSFCDGIV
NKDTVMTSKA CFVGNIVSMA SSPLYIVLLS YIWPDKETFD LNQFRNITVG DDIDTTELNA
IVSQLKDERI LKLQTYWSIG INLFILIGCY VIIPTALLGS NHDLSKSSFS GLIIVCLIWI
LVAAIYIILF PLWQGRKSLA NVISHIIRLK APENILLDGL TPKQSSEDVG DATSFHMDKL
DKEKEKSSEL KTA
