DUR33_SCHPO
ID DUR33_SCHPO Reviewed; 661 AA.
AC Q9URY6;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=Probable urea active transporter 3;
GN Name=dur3-3; ORFNames=SPAC869.03c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Involved in active transport of urea. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}. Golgi apparatus membrane; Multi-pass membrane
CC protein.
CC -!- SIMILARITY: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21)
CC family. {ECO:0000305}.
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DR EMBL; CU329670; CAB60013.1; -; Genomic_DNA.
DR PIR; T39114; T39114.
DR RefSeq; NP_595016.1; NM_001020447.2.
DR AlphaFoldDB; Q9URY6; -.
DR SMR; Q9URY6; -.
DR BioGRID; 279584; 22.
DR STRING; 4896.SPAC869.03c.1; -.
DR PaxDb; Q9URY6; -.
DR EnsemblFungi; SPAC869.03c.1; SPAC869.03c.1:pep; SPAC869.03c.
DR GeneID; 2543152; -.
DR KEGG; spo:SPAC869.03c; -.
DR PomBase; SPAC869.03c; -.
DR VEuPathDB; FungiDB:SPAC869.03c; -.
DR eggNOG; KOG2348; Eukaryota.
DR HOGENOM; CLU_010778_2_1_1; -.
DR InParanoid; Q9URY6; -.
DR OMA; VSHYFIC; -.
DR PhylomeDB; Q9URY6; -.
DR PRO; PR:Q9URY6; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0005794; C:Golgi apparatus; HDA:PomBase.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISO:PomBase.
DR GO; GO:0015489; F:putrescine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015606; F:spermidine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015204; F:urea transmembrane transporter activity; ISO:PomBase.
DR GO; GO:0015847; P:putrescine transport; IBA:GO_Central.
DR GO; GO:0015848; P:spermidine transport; IBA:GO_Central.
DR GO; GO:0071918; P:urea transmembrane transport; ISO:PomBase.
DR GO; GO:0015840; P:urea transport; IBA:GO_Central.
DR Gene3D; 1.20.1730.10; -; 1.
DR InterPro; IPR031155; DUR.
DR InterPro; IPR038377; Na/Glc_symporter_sf.
DR InterPro; IPR001734; Na/solute_symporter.
DR PANTHER; PTHR46154; PTHR46154; 1.
DR Pfam; PF00474; SSF; 1.
DR TIGRFAMs; TIGR00813; sss; 1.
DR PROSITE; PS50283; NA_SOLUT_SYMP_3; 1.
PE 3: Inferred from homology;
KW Golgi apparatus; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..661
FT /note="Probable urea active transporter 3"
FT /id="PRO_0000314768"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..271
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 352..372
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 397..417
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 419..439
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 454..474
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 495..515
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 556..576
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 591..611
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 661 AA; 71966 MW; 2D3E5B7846F63A93 CRC64;
MTETVLNQGY GYGIVIGLGF AFAIVMILVT YVLKRYVGEV QDSEHFTTAS RSVKTGLISS
AVVSSWTWPG TLLTSAGMAY EYGVCGSMWY SFAFTVQITF FTVIALQVKR VAPGAHTIVE
IVKARFGQAS HAVFLFYALG TNIIVSAMLL LGGSQAISAI TGMHVVAAGF LLPLGVWLYT
VSGGLKSTFL SDWTHTVIVY IVILITLFVA YTSSVHIGSI DKMYDLLTEV SKTNPSTGYK
GSYLTVTNRD AVFVGWNIVI GGFATVFCDP SYGQKAIAAK PISAMKGYFA GGLAWLIVPW
AMGSAAALSC LALTNNPVSV TYPDPVSSKQ VSEGMPLLYG MTALMGKNGA AAGVLILFMA
STSATSAELV AFSSVMTYDV YRNYFRPNAS GKELVRVTHV FVTIFAVCMG ALAVLFNYIG
ITISWIITFI GIALGPAVFG ITLTLFWKKM NKYGMIIGCP MGSITGVVCW VGSCYKFSNG
VVNKTTLNTP YANAVGNFTG LFSGLIYIVL ISYFFPNKSD DLNNLNEKFV LGDDATAEEI
VDAETEKKQL DRSLRIGIFV SWIIFFILVI IVPLPMYGSK YIFSKLFFRG WIIVIIIWTL
IAALYITFYP LYESRDTIVY LCKLAIGKAK APEPMNYVDA VEVEIESLSD DDKEKKANDF
L
