ID   DUS14_BOVIN             Reviewed;         198 AA.
AC   Q17QM8;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Dual specificity protein phosphatase 14;
DE            EC=3.1.3.16;
DE            EC=3.1.3.48;
GN   Name=DUSP14;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Basal ganglia;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the inactivation of MAP kinases. Dephosphorylates
CC       ERK, JNK and p38 MAP-kinases (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE-
CC         ProRule:PRU10044};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:83421; EC=3.1.3.16;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC         COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:61977; EC=3.1.3.16;
CC   -!- SUBUNIT: Interacts with CD28. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC       receptor class dual specificity subfamily. {ECO:0000305}.
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DR   EMBL; BC118267; AAI18268.1; -; mRNA.
DR   RefSeq; NP_001068776.1; NM_001075308.1.
DR   RefSeq; XP_005220051.1; XM_005219994.3.
DR   RefSeq; XP_010814059.1; XM_010815757.2.
DR   AlphaFoldDB; Q17QM8; -.
DR   SMR; Q17QM8; -.
DR   STRING; 9913.ENSBTAP00000013570; -.
DR   PaxDb; Q17QM8; -.
DR   PRIDE; Q17QM8; -.
DR   Ensembl; ENSBTAT00000013570; ENSBTAP00000013570; ENSBTAG00000010279.
DR   GeneID; 507294; -.
DR   KEGG; bta:507294; -.
DR   CTD; 11072; -.
DR   VEuPathDB; HostDB:ENSBTAG00000010279; -.
DR   VGNC; VGNC:28252; DUSP14.
DR   eggNOG; KOG1718; Eukaryota.
DR   GeneTree; ENSGT00940000160675; -.
DR   HOGENOM; CLU_027074_3_2_1; -.
DR   InParanoid; Q17QM8; -.
DR   OMA; IPDVYDR; -.
DR   OrthoDB; 1576308at2759; -.
DR   TreeFam; TF316009; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000010279; Expressed in surface of tongue and 103 other tissues.
DR   GO; GO:0017017; F:MAP kinase tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR   GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006470; P:protein dephosphorylation; IEA:InterPro.
DR   Gene3D; 3.90.190.10; -; 1.
DR   InterPro; IPR020420; Atypical_DUSP_subfamB.
DR   InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR000387; Tyr_Pase_dom.
DR   InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR   Pfam; PF00782; DSPc; 1.
DR   PRINTS; PR01910; ADSPHPHTASEB.
DR   SMART; SM00195; DSPc; 1.
DR   SUPFAM; SSF52799; SSF52799; 1.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR   PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Protein phosphatase; Reference proteome.
FT   CHAIN           1..198
FT                   /note="Dual specificity protein phosphatase 14"
FT                   /id="PRO_0000283054"
FT   DOMAIN          26..167
FT                   /note="Tyrosine-protein phosphatase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00160"
FT   ACT_SITE        111
FT                   /note="Phosphocysteine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00160"
SQ   SEQUENCE   198 AA;  22237 MW;  1FAAADC68CF8FDBE CRC64;
     MSSRGHSTLP RTLMAPRMIS EGDLGGIAQI TSSLFLGRGS VASNRHLLQA RGITCIVNAT
     IEIPNFNWPQ FEYVKVPLAD MPHAPIGLYF DTVADKIHSV SRKHGATLVH CAAGVSRSAT
     LCIAYLMKFH NVCLLEAYNW VKARRPVIRP NVGFWRQLID YERQLFGKST VKMVQTPYGI
     VPDVYEKESR HLLPYWGI