ADHR_BACSU
ID ADHR_BACSU Reviewed; 140 AA.
AC O06008; Q795Z1;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 07-JUL-2009, sequence version 2.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=HTH-type transcriptional regulator AdhR;
GN Name=adhR; Synonyms=yraB; OrderedLocusNames=BSU27000;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9141695; DOI=10.1099/00221287-143-4-1321;
RA Parro V., San Roman M., Galindo I., Purnelle B., Bolotin A., Sorokin A.,
RA Mellado R.P.;
RT "A 23911 bp region of the Bacillus subtilis genome comprising genes located
RT upstream and downstream of the lev operon.";
RL Microbiology 143:1321-1326(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP SEQUENCE REVISION TO 74.
RX PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT 168 reference genome a decade later.";
RL Microbiology 155:1758-1775(2009).
RN [4]
RP DNA-BINDING, INDUCTION, MUTAGENESIS OF CYS-52, DISRUPTION PHENOTYPE, AND
RP FUNCTION.
RC STRAIN=168;
RX PubMed=19170879; DOI=10.1111/j.1365-2958.2008.06568.x;
RA Nguyen T.T.H., Eiamphungporn W., Maeder U., Liebeke M., Lalk M., Hecker M.,
RA Helmann J.D., Antelmann H.;
RT "Genome-wide responses to carbonyl electrophiles in Bacillus subtilis:
RT control of the thiol-dependent formaldehyde dehydrogenase AdhA and cysteine
RT proteinase YraA by the MerR-family regulator YraB (AdhR).";
RL Mol. Microbiol. 71:876-894(2009).
CC -!- FUNCTION: Transcriptional regulator involved in the response to
CC aldehyde stress. Binds to the promoter region of the adhA-yraA operon,
CC the yraC and its own promoter region; binding is unchanged in the
CC presence of aldehydes. {ECO:0000269|PubMed:19170879}.
CC -!- INDUCTION: By aldehyde stress, positively regulates its own expression.
CC {ECO:0000269|PubMed:19170879}.
CC -!- DISRUPTION PHENOTYPE: Loss of expression of the adhA-yraA operon in
CC response to formaldehyde and methylgloxal.
CC {ECO:0000269|PubMed:19170879}.
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DR EMBL; X92868; CAA63468.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB14642.2; -; Genomic_DNA.
DR PIR; B69970; B69970.
DR RefSeq; NP_390578.2; NC_000964.3.
DR RefSeq; WP_004398725.1; NZ_JNCM01000036.1.
DR AlphaFoldDB; O06008; -.
DR SMR; O06008; -.
DR STRING; 224308.BSU27000; -.
DR PaxDb; O06008; -.
DR PRIDE; O06008; -.
DR EnsemblBacteria; CAB14642; CAB14642; BSU_27000.
DR GeneID; 937605; -.
DR KEGG; bsu:BSU27000; -.
DR PATRIC; fig|224308.179.peg.2932; -.
DR eggNOG; COG0789; Bacteria.
DR InParanoid; O06008; -.
DR OMA; FIKCMRN; -.
DR PhylomeDB; O06008; -.
DR BioCyc; BSUB:BSU27000-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR009061; DNA-bd_dom_put_sf.
DR InterPro; IPR000551; MerR-type_HTH_dom.
DR Pfam; PF13411; MerR_1; 1.
DR PRINTS; PR00040; HTHMERR.
DR SMART; SM00422; HTH_MERR; 1.
DR SUPFAM; SSF46955; SSF46955; 1.
DR PROSITE; PS50937; HTH_MERR_2; 1.
PE 1: Evidence at protein level;
KW Activator; Coiled coil; DNA-binding; Reference proteome; Stress response;
KW Transcription; Transcription regulation.
FT CHAIN 1..140
FT /note="HTH-type transcriptional regulator AdhR"
FT /id="PRO_0000361681"
FT DOMAIN 1..69
FT /note="HTH merR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
FT DNA_BIND 3..22
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
FT REGION 120..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 75..125
FT /evidence="ECO:0000255"
FT MUTAGEN 52
FT /note="C->A: Required to activate transcription of the
FT adhA-yraA operon."
FT /evidence="ECO:0000269|PubMed:19170879"
FT CONFLICT 74
FT /note="D -> H (in Ref. 1; CAA63468)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 140 AA; 16416 MW; 2831E46F5C4F07FA CRC64;
MNIAQVAKQF GLTAATLRYY ERVGLIPPVK RKDSGIRDYD EEDIKWIEFI KCMRNAGLSI
EALIEYTTLF TEGDRTVEAR KNILADERQR LIEKRKEIDE TIKRLDTKIK DYDGKLRENE
AKLKSRPKTE SLHGSVEQRR
