ID   ADHR_DROER              Reviewed;         202 AA.
AC   P28485;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Alcohol dehydrogenase-related 31 kDa protein;
DE   Flags: Fragment;
GN   Name=Adhr; Synonyms=Adh-dup;
OS   Drosophila erecta (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7220;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Gif-sur-Yvette stock 154.1;
RX   PubMed=8170369; DOI=10.1093/oxfordjournals.molbev.a040110;
RA   Jeffs P.S., Holmes E.C., Ashburner M.;
RT   "The molecular evolution of the alcohol dehydrogenase and alcohol
RT   dehydrogenase-related genes in the Drosophila melanogaster species
RT   subgroup.";
RL   Mol. Biol. Evol. 11:287-304(1994).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; X54116; CAA38058.1; -; Genomic_DNA.
DR   AlphaFoldDB; P28485; -.
DR   SMR; P28485; -.
DR   STRING; 7220.FBpp0143667; -.
DR   eggNOG; KOG4169; Eukaryota.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002427; ADH-rel.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR01170; ADHRELATED.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase.
FT   CHAIN           1..>202
FT                   /note="Alcohol dehydrogenase-related 31 kDa protein"
FT                   /id="PRO_0000054503"
FT   ACT_SITE        152
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         11..34
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         139
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   NON_TER         202
SQ   SEQUENCE   202 AA;  22111 MW;  712696BB6DE16F12 CRC64;
     MFDLTGKHVC YVADCGGIAL ETSKVLMTKN IAKLAILQSL ENPQAIAQLQ SIKPSTQIFF
     WTYDVTMARE EMKKYFDEVM VQMDYIDVLI NGATLCDENN IDATINTNLT GMMNTVATVL
     PHMDRKMGGS GGLIVNVTSV IGLDPSPVFC AYSASKFGVI GFTRSLADPL YYSQNGVAVM
     AVCCGPTRVF VDRELKAFLE YG