ID   DUX3_HUMAN              Reviewed;         197 AA.
AC   Q96PT4; Q9UND2;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Putative double homeobox protein 3;
GN   Name=DUX3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY,
RP   ALTERNATIVE SPLICING, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Blood;
RX   PubMed=11245978; DOI=10.1016/s0378-1119(00)00602-8;
RA   Beckers M.-C., Gabrieels J., van der Maarel S., De Vriese A., Frants R.R.,
RA   Collen D., Belayew A.;
RT   "Active genes in junk DNA? Characterization of DUX genes embedded within
RT   3.3 kb repeated elements.";
RL   Gene 264:51-57(2001).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q96PT4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q96PT4-2; Sequence=VSP_020958;
CC   -!- TISSUE SPECIFICITY: Expressed in hepatoma Hep3B cells.
CC       {ECO:0000269|PubMed:11245978}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in fetal tissue.
CC       {ECO:0000269|PubMed:11245978}.
CC   -!- MISCELLANEOUS: DUX genes are present in 3.3-kilobase elements, a tandem
CC       repeat family scattered in the genome found on the short arms of all
CC       acrocentric chromosomes as well as on several other chromosomes. May be
CC       functional despite lack of introns and of a poly(A) addition signal.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
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DR   EMBL; AF133130; AAL02242.1; -; Genomic_DNA.
DR   EMBL; AF133130; AAD33597.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q96PT4; -.
DR   SMR; Q96PT4; -.
DR   BioGRID; 117751; 27.
DR   IntAct; Q96PT4; 4.
DR   MINT; Q96PT4; -.
DR   BioMuta; HGNC:3081; -.
DR   DMDM; 74717114; -.
DR   MassIVE; Q96PT4; -.
DR   PeptideAtlas; Q96PT4; -.
DR   PRIDE; Q96PT4; -.
DR   DNASU; 26582; -.
DR   GeneCards; DUX3; -.
DR   HGNC; HGNC:3081; DUX3.
DR   MIM; 611443; gene.
DR   neXtProt; NX_Q96PT4; -.
DR   PharmGKB; PA27537; -.
DR   InParanoid; Q96PT4; -.
DR   PhylomeDB; Q96PT4; -.
DR   PathwayCommons; Q96PT4; -.
DR   SignaLink; Q96PT4; -.
DR   Pharos; Q96PT4; Tdark.
DR   PRO; PR:Q96PT4; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q96PT4; protein.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 2.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 2.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 2.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 2.
PE   2: Evidence at transcript level;
KW   Alternative splicing; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Repeat.
FT   CHAIN           1..197
FT                   /note="Putative double homeobox protein 3"
FT                   /id="PRO_0000252412"
FT   DNA_BIND        46..105
FT                   /note="Homeobox 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   DNA_BIND        121..180
FT                   /note="Homeobox 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          102..127
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..27
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_020958"
SQ   SEQUENCE   197 AA;  22130 MW;  4545E2738BFCE954 CRC64;
     MPAEVHGSPP ASLCPCPSVK FRPGLPAMAL LTALDDTLPE EAQGPGRRMI LLSTPSQSDA
     LRACFERNLY PGIATKEQLA QGIDIPEPRV QIWFQNERSC QLRQHRRQSR PWPGRRDPQK
     GRRKRTAITG SQTALLLRAF EKDRFPGIPA REELARETGL PESRIQLWFQ NRRARHWGQS
     GRAPTQASIR CNAAPIG