DUXA_HUMAN
ID DUXA_HUMAN Reviewed; 204 AA.
AC A6NLW8;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Double homeobox protein A {ECO:0000305};
GN Name=DUXA {ECO:0000312|HGNC:HGNC:32179};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP IDENTIFICATION.
RX PubMed=17005330; DOI=10.1016/j.gene.2006.07.034;
RA Booth H.A., Holland P.W.H.;
RT "Annotation, nomenclature and evolution of four novel homeobox genes
RT expressed in the human germ line.";
RL Gene 387:7-14(2007).
RN [3]
RP FUNCTION, DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RX PubMed=27412763; DOI=10.1038/srep28995;
RA Madissoon E., Jouhilahti E.M., Vesterlund L., Toehoenen V., Krjutskov K.,
RA Petropoulos S., Einarsdottir E., Linnarsson S., Lanner F., Maansson R.,
RA Hovatta O., Buerglin T.R., Katayama S., Kere J.;
RT "Characterization and target genes of nine human PRD-like homeobox domain
RT genes expressed exclusively in early embryos.";
RL Sci. Rep. 6:28995-28995(2016).
CC -!- FUNCTION: Transcription factor that acts as repressor.
CC {ECO:0000269|PubMed:27412763}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- TISSUE SPECIFICITY: Expressed in embryonic stem cells.
CC {ECO:0000269|PubMed:27412763}.
CC -!- DEVELOPMENTAL STAGE: Expressed in single blastomeres from 8-cell stage
CC embryos. {ECO:0000269|PubMed:27412763}.
CC -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
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DR EMBL; AC025588; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS33126.1; -.
DR RefSeq; NP_001012747.1; NM_001012729.1.
DR AlphaFoldDB; A6NLW8; -.
DR SMR; A6NLW8; -.
DR STRING; 9606.ENSP00000452398; -.
DR iPTMnet; A6NLW8; -.
DR PhosphoSitePlus; A6NLW8; -.
DR BioMuta; DUXA; -.
DR MassIVE; A6NLW8; -.
DR PaxDb; A6NLW8; -.
DR PeptideAtlas; A6NLW8; -.
DR PRIDE; A6NLW8; -.
DR ProteomicsDB; 1495; -.
DR Antibodypedia; 59168; 27 antibodies from 11 providers.
DR DNASU; 503835; -.
DR Ensembl; ENST00000554048.3; ENSP00000452398.1; ENSG00000258873.3.
DR GeneID; 503835; -.
DR KEGG; hsa:503835; -.
DR MANE-Select; ENST00000554048.3; ENSP00000452398.1; NM_001012729.2; NP_001012747.1.
DR UCSC; uc002qoa.2; human.
DR CTD; 503835; -.
DR DisGeNET; 503835; -.
DR GeneCards; DUXA; -.
DR HGNC; HGNC:32179; DUXA.
DR HPA; ENSG00000258873; Not detected.
DR MIM; 611168; gene.
DR neXtProt; NX_A6NLW8; -.
DR OpenTargets; ENSG00000258873; -.
DR PharmGKB; PA142671924; -.
DR VEuPathDB; HostDB:ENSG00000258873; -.
DR eggNOG; KOG0490; Eukaryota.
DR GeneTree; ENSGT00940000163365; -.
DR HOGENOM; CLU_049543_1_0_1; -.
DR InParanoid; A6NLW8; -.
DR OMA; SHKMVTT; -.
DR OrthoDB; 1580567at2759; -.
DR PhylomeDB; A6NLW8; -.
DR TreeFam; TF340750; -.
DR PathwayCommons; A6NLW8; -.
DR BioGRID-ORCS; 503835; 271 hits in 1057 CRISPR screens.
DR ChiTaRS; DUXA; human.
DR GenomeRNAi; 503835; -.
DR Pharos; A6NLW8; Tdark.
DR PRO; PR:A6NLW8; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; A6NLW8; protein.
DR Bgee; ENSG00000258873; Expressed in calcaneal tendon and 15 other tissues.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR000047; HTH_motif.
DR Pfam; PF00046; Homeodomain; 2.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 2.
DR SUPFAM; SSF46689; SSF46689; 2.
DR PROSITE; PS50071; HOMEOBOX_2; 2.
PE 2: Evidence at transcript level;
KW DNA-binding; Homeobox; Nucleus; Reference proteome; Repeat; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..204
FT /note="Double homeobox protein A"
FT /id="PRO_0000311327"
FT DNA_BIND 15..74
FT /note="Homeobox 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT DNA_BIND 101..160
FT /note="Homeobox 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 73..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 163..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..94
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 204 AA; 23817 MW; 56A0906E62A3BB56 CRC64;
MAEDTYSHKM VKTNHRRCRT KFTEEQLKIL INTFNQKPYP GYATKQKLAL EINTEESRIQ
IWFQNRRARH GFQKRPEAET LESSQSQGQD QPGVEFQSRE ARRCRTTYSA SQLHTLIKAF
MKNPYPGIDS REELAKEIGV PESRVQIWFQ NRRSRLLLQR KREPVASLEQ EEQGKIPEGL
QGAEDTQNGT NFTSDSHFSG ARTW
