ID   DUXB_HUMAN              Reviewed;         345 AA.
AC   A0A1W2PPF3;
DT   18-SEP-2019, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2017, sequence version 1.
DT   03-AUG-2022, entry version 27.
DE   RecName: Full=Double homeobox protein B {ECO:0000305};
GN   Name=DUXB {ECO:0000312|HGNC:HGNC:33345};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA   Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA   Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA   Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA   Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA   Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA   Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA   Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA   Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA   Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA   Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA   Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA   Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA   Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA   Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA   Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA   Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA   DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA   Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA   Myers R.M., Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-315.
RX   PubMed=26360614; DOI=10.1038/ncomms9207;
RA   Toehoenen V., Katayama S., Vesterlund L., Jouhilahti E.M., Sheikhi M.,
RA   Madissoon E., Filippini-Cattaneo G., Jaconi M., Johnsson A., Buerglin T.R.,
RA   Linnarsson S., Hovatta O., Kere J.;
RT   "Novel PRD-like homeodomain transcription factors and retrotransposon
RT   elements in early human development.";
RL   Nat. Commun. 6:8207-8207(2015).
RN   [3]
RP   DEVELOPMENTAL STAGE.
RX   PubMed=27412763; DOI=10.1038/srep28995;
RA   Madissoon E., Jouhilahti E.M., Vesterlund L., Toehoenen V., Krjutskov K.,
RA   Petropoulos S., Einarsdottir E., Linnarsson S., Lanner F., Maansson R.,
RA   Hovatta O., Buerglin T.R., Katayama S., Kere J.;
RT   "Characterization and target genes of nine human PRD-like homeobox domain
RT   genes expressed exclusively in early embryos.";
RL   Sci. Rep. 6:28995-28995(2016).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in single blastomeres from 8-cell stage
CC       embryos. {ECO:0000269|PubMed:27412763}.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC025287; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; LN651084; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS86542.1; -.
DR   AlphaFoldDB; A0A1W2PPF3; -.
DR   SMR; A0A1W2PPF3; -.
DR   BioMuta; DUXB; -.
DR   MassIVE; A0A1W2PPF3; -.
DR   Ensembl; ENST00000633875.4; ENSP00000491301.1; ENSG00000282757.4.
DR   MANE-Select; ENST00000633875.4; ENSP00000491301.1; NM_001351307.2; NP_001338236.1.
DR   GeneCards; DUXB; -.
DR   HGNC; HGNC:33345; DUXB.
DR   HPA; ENSG00000282757; Not detected.
DR   MIM; 618698; gene.
DR   neXtProt; NX_A0A1W2PPF3; -.
DR   VEuPathDB; HostDB:ENSG00000282757; -.
DR   GeneTree; ENSGT00940000165352; -.
DR   OMA; PSTQAPW; -.
DR   PRO; PR:A0A1W2PPF3; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   RNAct; A0A1W2PPF3; protein.
DR   Bgee; ENSG00000282757; Expressed in calcaneal tendon and 46 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 2.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 2.
DR   SMART; SM00389; HOX; 2.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 2.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..345
FT                   /note="Double homeobox protein B"
FT                   /id="PRO_0000447998"
FT   DNA_BIND        15..74
FT                   /note="Homeobox 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   DNA_BIND        102..161
FT                   /note="Homeobox 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          282..314
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        18
FT                   /note="N -> D (in Ref. 2; LN651084)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        135
FT                   /note="L -> P (in Ref. 2; LN651084)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        166
FT                   /note="M -> T (in Ref. 2; LN651084)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   345 AA;  40370 MW;  D34EEAFD50A88A34 CRC64;
     MNLEGTSGGI LQKEFWRNRI QYNQSQKDIL QSWFQHDPFP DKAAREQLAK EIGVPESNIQ
     VWFKNYRVKQ RKLDYKCFSE KDQTQGHDQS QHLTQEYLPK EARQKQTFIT WTQKNRLVQA
     FERNPFPDIA TRKKLAEQTG LQESRIQMWF QKQRSLYLKK SRMEPMNLLV DDPNERPDAT
     VGWHPINLFL PTDSSHYFSC SHSSSGHETL PPVLPSTQAP WDPFRFHVSQ GPNVMIMQPT
     QAVQEGEKSD QPLIIPNHLL TLPILTKDLD TPTPFWLQYQ EEHQNHKEHS GSGVPQVKSH
     SQPEPEHREQ QPLNLGQFDI SNILQRWDEI CQALLAEWDP LKGTH