ID   ADHR_DROIM              Reviewed;         273 AA.
AC   Q07586;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Alcohol dehydrogenase-related 31 kDa protein;
GN   Name=Adhr; Synonyms=Adh-dup;
OS   Drosophila immigrans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7250;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8482531; DOI=10.1016/0378-1119(93)90364-9;
RA   Albalat R., Gonzalez-Duarte R.;
RT   "Adh and Adh-dup sequences of Drosophila lebanonensis and D. immigrans:
RT   interspecies comparisons.";
RL   Gene 126:171-178(1993).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M97638; AAA28358.1; -; Genomic_DNA.
DR   PIR; JN0567; JN0567.
DR   AlphaFoldDB; Q07586; -.
DR   SMR; Q07586; -.
DR   FlyBase; FBgn0012412; Dimm\Adhr.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002427; ADH-rel.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR01170; ADHRELATED.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase.
FT   CHAIN           1..273
FT                   /note="Alcohol dehydrogenase-related 31 kDa protein"
FT                   /id="PRO_0000054505"
FT   ACT_SITE        152
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         11..34
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         139
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   273 AA;  30430 MW;  84D0236C799ED827 CRC64;
     MFDLTGKNVC YVADCGGIAL ETCKVLMTKN IAKLAMLYSV ENPQAIAQLQ AIKPSTQIFF
     WTYDVTMARE DMKQYFDEVM VQMDYIDVLI NGATLCDEQN IDDTINTNLT GMMNTCATVL
     PYMDKQQLGK GGLIVNVTSV VGLDPSPVFC AYSASKFGVI GFTRSLADPL YYTQNGVAVM
     AVCCGPTKMF VDRQLTAFLS YGQPFVDRLR TAPCQSTTIC AKNIVKAIEC AVNGRIWIAD
     KGELELVKLH WYWHMADQLV NYMHSTSEEK DED