DVA1_DICVI
ID DVA1_DICVI Reviewed; 1557 AA.
AC Q24702;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 57.
DE RecName: Full=DVA-1 polyprotein;
DE AltName: Full=Allergen 1;
DE AltName: Full=Antigen 1;
DE AltName: Full=Nematode polyprotein allergen DVA-1;
DE Short=NPA DVA-1;
DE Contains:
DE RecName: Full=DVA-1 unit A;
DE Contains:
DE RecName: Full=DVA-1 unit B;
DE Contains:
DE RecName: Full=DVA-1 unit C;
DE Contains:
DE RecName: Full=DVA-1 unit D;
DE Contains:
DE RecName: Full=DVA-1 unit E;
DE Contains:
DE RecName: Full=DVA-1 unit F;
DE Contains:
DE RecName: Full=DVA-1 unit G;
DE Contains:
DE RecName: Full=DVA-1 unit H;
DE Contains:
DE RecName: Full=DVA-1 unit I;
DE Contains:
DE RecName: Full=DVA-1 unit J;
DE Contains:
DE RecName: Full=DVA-1 unit K;
DE Contains:
DE RecName: Full=DVA-1 unit L;
DE Contains:
DE RecName: Full=C-terminal extension peptide;
DE Flags: Precursor;
GN Name=DVA-1;
OS Dictyocaulus viviparus (Bovine lungworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC Trichostrongyloidea; Dictyocaulidae; Dictyocaulinae; Dictyocaulus.
OX NCBI_TaxID=29172;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8538702; DOI=10.1016/0166-6851(95)00088-i;
RA Britton C., Moore J., Gilleard J.S., Kennedy M.W.;
RT "Extensive diversity in repeat unit sequences of the cDNA encoding the
RT polyprotein antigen/allergen from the bovine lungworm Dictyocaulus
RT viviparus.";
RL Mol. Biochem. Parasitol. 72:77-88(1995).
RN [2]
RP FATTY ACID/RETINOID-BINDING.
RX PubMed=7642601; DOI=10.1074/jbc.270.33.19277;
RA Kennedy M.W., Britton C., Price N.C., Kelly S.M., Cooper A.;
RT "The DvA-1 polyprotein of the parasitic nematode Dictyocaulus viviparus. A
RT small helix-rich lipid-binding protein.";
RL J. Biol. Chem. 270:19277-19281(1995).
CC -!- FUNCTION: Has high binding affinity for fatty acids and retinoids.
CC -!- PTM: Nematode polyprotein allergens (NPAs) are synthesized as large
CC polypeptides that are subsequently proteolytically cleaved to active
CC polypeptide units.
CC -!- ALLERGEN: Causes an allergic reaction in human.
CC -!- SIMILARITY: Belongs to the NPA family. {ECO:0000305}.
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DR EMBL; U02568; AAC47403.1; -; mRNA.
DR PIR; T18412; T18412.
DR AlphaFoldDB; Q24702; -.
DR SMR; Q24702; -.
DR PRIDE; Q24702; -.
DR GO; GO:0019841; F:retinol binding; IEA:UniProtKB-KW.
DR Gene3D; 1.10.533.30; -; 12.
DR InterPro; IPR032487; ABA-1_nematode.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR038289; DVA-1_sf.
DR Pfam; PF16469; NPA; 12.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Allergen; Cleavage on pair of basic residues; Glycoprotein; Lipid-binding;
KW Repeat; Retinol-binding; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT PROPEP 22..60
FT /id="PRO_0000042229"
FT PEPTIDE 61..213
FT /note="DVA-1 unit A"
FT /evidence="ECO:0000255"
FT /id="PRO_0000021130"
FT PEPTIDE 214..334
FT /note="DVA-1 unit B"
FT /evidence="ECO:0000255"
FT /id="PRO_0000021131"
FT PEPTIDE 335..480
FT /note="DVA-1 unit C"
FT /evidence="ECO:0000255"
FT /id="PRO_0000021132"
FT PEPTIDE 481..606
FT /note="DVA-1 unit D"
FT /evidence="ECO:0000255"
FT /id="PRO_0000021133"
FT PEPTIDE 607..737
FT /note="DVA-1 unit E"
FT /evidence="ECO:0000255"
FT /id="PRO_0000021134"
FT PEPTIDE 738..869
FT /note="DVA-1 unit F"
FT /evidence="ECO:0000255"
FT /id="PRO_0000021135"
FT PEPTIDE 870..1003
FT /note="DVA-1 unit G"
FT /evidence="ECO:0000255"
FT /id="PRO_0000021136"
FT PEPTIDE 1004..1074
FT /note="DVA-1 unit H"
FT /evidence="ECO:0000255"
FT /id="PRO_0000021137"
FT PEPTIDE 1075..1208
FT /note="DVA-1 unit I"
FT /evidence="ECO:0000255"
FT /id="PRO_0000021138"
FT PEPTIDE 1209..1342
FT /note="DVA-1 unit J"
FT /evidence="ECO:0000255"
FT /id="PRO_0000021139"
FT PEPTIDE 1343..1475
FT /note="DVA-1 unit K"
FT /evidence="ECO:0000255"
FT /id="PRO_0000021140"
FT PEPTIDE 1476..1545
FT /note="DVA-1 unit L"
FT /evidence="ECO:0000255"
FT /id="PRO_0000021141"
FT PEPTIDE 1546..1557
FT /note="C-terminal extension peptide"
FT /evidence="ECO:0000255"
FT /id="PRO_0000021142"
FT CARBOHYD 997
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 946
FT /note="H -> Y"
FT VARIANT 948
FT /note="L -> V"
FT VARIANT 955
FT /note="H -> D"
FT VARIANT 974
FT /note="E -> G"
FT VARIANT 990
FT /note="G -> A"
FT VARIANT 1543
FT /note="A -> V"
SQ SEQUENCE 1557 AA; 182601 MW; 33717911CF55BD4B CRC64;
MKSTSFITLL LLSYFIVEAH SSIFHWDDER LFKHDDTHSW LTDVQKAELE TLKHQPIQLR
DKTLEFYNQL PTNEKAIWDK FYTKYCVVWL KEVASDEEIG KLKELESEKN KEALLTSIYS
FKDRLDEVDQ RKVELWKETC DEYVTKGLSR KRRDSNKNFE EFIYWMTDEQ KQSMNDMKTA
GKSFNEIHKE GRKYFKALTI DKQSSLKEQF KDKCKKYFMQ IANSDEVEKI KSLNDDEIRH
VVKNAVARLN GEDKEFAVKM ETLCEDVLAF KARKNDIDDK INRRLSWMTD EQKQVVKQLY
ADGRSQADIR AKIFEFLSSI DGPAGVAAKA QIQKECYKWM EEVATAEEIA ALHELHEIDH
DGCRRKVREF IGRLPEDRKL EVEKDLPFCE KIWYRDHGDH NSHKHGAHHH HRHLAVRRRR
HLYAIEKFLD WLKPEQKHEL EKIENSGAHF DDVIAEVKKF YGLLPEEKKI ELKAKFKSQC
YDWVKEVATS EEMNDIMKMH ESKNHSDLMK RLTELENRLT EDQKHTIEHV REVCLGLWEV
QNTNKQHKQS LEEAMDAYLS WMTDEDKEKV KAIYETSNRQ TFYDEILKIM ESSEDEVKAK
ATEKLEAACK HYGTNILGEE NVDIIREMKK NGATFEEISN RVDELIEGIT DSDRKEKAYR
MSKLCKKIYS LGHSKQLQQY DFENVLQKYL TWLDDSQKNE LRTMSDNKEK IYKKIIDYFD
GTIGEVKEKA VEELQLACNH YIKSIVGEEK AMEIKQLKEE GKSSEEIAKK VEDVINQISD
ESIRSRADEA LLVCKRIFGI VKRLRRDNSE IHSLEEAMER YLTWLSDDQK IVIKSIYDVN
DRKVLYEKIM EFFDDAIGET KQKAAKELKD ACKHYVKDLI GEENGNLLRE MKENGASNEA
IATKVEEMIE AITDETKRAQ AMRASTSCRK VYGVVQRFRR DHHHEHNLDE ALEKHFTWLN
EEQKSQLKTI YESEDREALH KKVWEFFEAG AGLRASNASK KIYGVAKRFR RDHHHEHNLD
EALEKYLTWL NEEQKSQMKT IYESGDREAL YKKVLEFFEA ATGEVKEKAA VELKSACRHY
IKDYIGDEKA EKIKEMKESG VSTEEISKKV DEFIAMITDD EKKAKALRAS SACKKIYGVA
KRFRRDHHHE HNLEEALEKY LTWLNEEQKS QMKTIYESGD REALYKKVLE FFEAATGEVK
EKAAVELKSA CRHYIKDYIG DEKAEKIKEM KESGVSTEEI SKKVDEFIAM ITDDEKKAKA
LRASNACKKI YGVAKRLRRD HHHEHNLEEA MGKYLSWMSD EQQAQVKKIY GTGDRLATYN
KVMELFESVP SDEKEKATSQ LKAACRHYIK DFIGKDNLAV IKEMKESGAT NEAIGEKIDE
FIAGLDDEQK KAQAQRAASA CKKIYGVKSR KRREHYEIDV DEAISKYLTW LNEEQKAEIK
QLKEKDEKQT IGKKIMEFFE LTSGDDKEKA REQLKAACKH YVKMYVGEEK AAELKKLKDS
GISLEEMSKK VTETIETIED EAVRAKARRI HSYCQRIFGI TKARRHLAMK HHRFYDD
